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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for HNF1A_HNF1B

Z-value: 1.82

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Transcription factors associated with HNF1A_HNF1B

Gene Symbol Gene ID Gene Info
HNF1A
ENSG00000135100.13 HNF1 homeobox A
HNF1B
ENSG00000108753.8 HNF1 homeobox B

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HNF1Ahg19_v2_chr12_+_121416437_1214164790.954.6e-02Click!
HNF1Bhg19_v2_chr17_-_36105009_361050600.762.4e-01Click!

Activity profile of HNF1A_HNF1B motif

Sorted Z-values of HNF1A_HNF1B motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_204183071 1.55 ENST00000308302.3
GOLT1A
golgi transport 1A
chr17_+_4692230 1.53 ENST00000331264.7
GLTPD2
glycolipid transfer protein domain containing 2
chr17_+_73642315 1.33 ENST00000556126.2
SMIM6
small integral membrane protein 6
chr2_-_87248975 1.32 ENST00000409310.2
ENST00000355705.3
PLGLB1
plasminogen-like B1
chr17_+_73642486 1.09 ENST00000579469.1
SMIM6
small integral membrane protein 6
chr2_-_47572207 0.88 ENST00000441997.1
AC073283.4
AC073283.4
chr22_-_30970560 0.86 ENST00000402369.1
ENST00000406361.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr3_+_187930429 0.86 ENST00000420410.1
LPP
LIM domain containing preferred translocation partner in lipoma
chr22_-_30968839 0.86 ENST00000445645.1
ENST00000416358.1
ENST00000423371.1
ENST00000411821.1
ENST00000448604.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr1_-_168464875 0.86 ENST00000422253.1
RP5-968D22.3
RP5-968D22.3
chr19_+_50016610 0.82 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr9_-_116861337 0.80 ENST00000374118.3
KIF12
kinesin family member 12
chr14_+_38033252 0.76 ENST00000554829.1
RP11-356O9.1
RP11-356O9.1
chr7_-_27219849 0.76 ENST00000396344.4
HOXA10
homeobox A10
chr22_-_30968813 0.75 ENST00000443111.2
ENST00000443136.1
ENST00000426220.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr3_-_137834436 0.75 ENST00000327532.2
ENST00000467030.1
DZIP1L
DAZ interacting zinc finger protein 1-like
chr11_-_111649074 0.73 ENST00000534218.1
RP11-108O10.2
RP11-108O10.2
chr6_-_154751629 0.73 ENST00000424998.1
CNKSR3
CNKSR family member 3
chr20_+_43029911 0.72 ENST00000443598.2
ENST00000316099.4
ENST00000415691.2
HNF4A
hepatocyte nuclear factor 4, alpha
chr17_-_202579 0.72 ENST00000577079.1
ENST00000331302.7
ENST00000536489.2
RPH3AL
rabphilin 3A-like (without C2 domains)
chr5_+_125706998 0.70 ENST00000506445.1
GRAMD3
GRAM domain containing 3
chr14_+_65171099 0.70 ENST00000247226.7
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr19_+_50016411 0.69 ENST00000426395.3
ENST00000600273.1
ENST00000599988.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr11_-_117695449 0.69 ENST00000292079.2
FXYD2
FXYD domain containing ion transport regulator 2
chr3_+_187930491 0.60 ENST00000443217.1
LPP
LIM domain containing preferred translocation partner in lipoma
chr2_+_133174147 0.60 ENST00000329321.3
GPR39
G protein-coupled receptor 39
chr4_+_8201091 0.58 ENST00000382521.3
ENST00000245105.3
ENST00000457650.2
ENST00000539824.1
SH3TC1
SH3 domain and tetratricopeptide repeats 1
chr11_-_111649015 0.57 ENST00000529841.1
RP11-108O10.2
RP11-108O10.2
chr5_+_176514413 0.57 ENST00000513166.1
FGFR4
fibroblast growth factor receptor 4
chr20_+_35973080 0.56 ENST00000445403.1
SRC
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr16_+_81272287 0.54 ENST00000425577.2
ENST00000564552.1
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr22_+_45098067 0.54 ENST00000336985.6
ENST00000403696.1
ENST00000457960.1
ENST00000361473.5
PRR5
PRR5-ARHGAP8
proline rich 5 (renal)
PRR5-ARHGAP8 readthrough
chr20_+_42984330 0.53 ENST00000316673.4
ENST00000609795.1
ENST00000457232.1
ENST00000609262.1
HNF4A
hepatocyte nuclear factor 4, alpha
chr14_+_65170820 0.52 ENST00000555982.1
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr1_+_18807424 0.51 ENST00000400664.1
KLHDC7A
kelch domain containing 7A
chr16_-_69385681 0.51 ENST00000288025.3
TMED6
transmembrane emp24 protein transport domain containing 6
chr9_-_215744 0.50 ENST00000382387.2
C9orf66
chromosome 9 open reading frame 66
chr14_+_65171315 0.47 ENST00000394691.1
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr3_+_183948161 0.46 ENST00000426955.2
VWA5B2
von Willebrand factor A domain containing 5B2
chr2_-_47572105 0.43 ENST00000419035.1
ENST00000448713.1
ENST00000450550.1
ENST00000413185.2
AC073283.4
AC073283.4
chr16_-_57831914 0.42 ENST00000421376.2
KIFC3
kinesin family member C3
chr4_+_74347400 0.41 ENST00000226355.3
AFM
afamin
chr11_+_560956 0.41 ENST00000397582.3
ENST00000344375.4
ENST00000397583.3
RASSF7
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr1_+_17906970 0.41 ENST00000375415.1
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr7_-_27219632 0.40 ENST00000470747.4
RP1-170O19.20
Uncharacterized protein
chr14_+_21156915 0.40 ENST00000397990.4
ENST00000555597.1
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr8_-_95220775 0.40 ENST00000441892.2
ENST00000521491.1
ENST00000027335.3
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr1_+_84767289 0.40 ENST00000394834.3
ENST00000370669.1
SAMD13
sterile alpha motif domain containing 13
chr19_+_6464243 0.39 ENST00000600229.1
ENST00000356762.3
CRB3
crumbs homolog 3 (Drosophila)
chr17_-_26733179 0.39 ENST00000440501.1
ENST00000321666.5
SLC46A1
solute carrier family 46 (folate transporter), member 1
chr7_-_155601766 0.37 ENST00000430104.1
SHH
sonic hedgehog
chr10_+_99344071 0.37 ENST00000370647.4
ENST00000370646.4
HOGA1
4-hydroxy-2-oxoglutarate aldolase 1
chr11_-_117170403 0.37 ENST00000504995.1
BACE1
beta-site APP-cleaving enzyme 1
chr3_-_107596910 0.34 ENST00000464359.2
ENST00000464823.1
ENST00000466155.1
ENST00000473528.2
ENST00000608306.1
ENST00000488852.1
ENST00000608137.1
ENST00000608307.1
ENST00000609429.1
ENST00000601385.1
ENST00000475362.1
ENST00000600240.1
ENST00000600749.1
LINC00635
long intergenic non-protein coding RNA 635
chr2_+_88047606 0.33 ENST00000359481.4
PLGLB2
plasminogen-like B2
chr2_+_38177620 0.32 ENST00000402091.3
RMDN2
regulator of microtubule dynamics 2
chr2_-_228244013 0.32 ENST00000304568.3
TM4SF20
transmembrane 4 L six family member 20
chr22_-_22337154 0.32 ENST00000413067.2
ENST00000437929.1
ENST00000456075.1
ENST00000434517.1
ENST00000424393.1
ENST00000449704.1
ENST00000437103.1
TOP3B
topoisomerase (DNA) III beta
chr5_+_175976324 0.31 ENST00000261944.5
CDHR2
cadherin-related family member 2
chr18_-_2982869 0.31 ENST00000584915.1
LPIN2
lipin 2
chr16_-_75284758 0.31 ENST00000561970.1
BCAR1
breast cancer anti-estrogen resistance 1
chr16_+_21244986 0.30 ENST00000311620.5
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr7_-_50633078 0.29 ENST00000444124.2
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr6_-_127840048 0.29 ENST00000467753.1
SOGA3
SOGA family member 3
chr6_+_54172653 0.29 ENST00000370869.3
TINAG
tubulointerstitial nephritis antigen
chr7_+_141695633 0.28 ENST00000549489.2
MGAM
maltase-glucoamylase (alpha-glucosidase)
chr1_+_207262170 0.28 ENST00000367078.3
C4BPB
complement component 4 binding protein, beta
chr1_+_55505184 0.27 ENST00000302118.5
PCSK9
proprotein convertase subtilisin/kexin type 9
chr6_-_52628271 0.26 ENST00000493422.1
GSTA2
glutathione S-transferase alpha 2
chr12_-_76879852 0.25 ENST00000548341.1
OSBPL8
oxysterol binding protein-like 8
chr17_-_26733604 0.25 ENST00000584426.1
ENST00000584995.1
SLC46A1
solute carrier family 46 (folate transporter), member 1
chr4_-_155511887 0.24 ENST00000302053.3
ENST00000403106.3
FGA
fibrinogen alpha chain
chr3_-_49466686 0.24 ENST00000273598.3
ENST00000436744.2
NICN1
nicolin 1
chr22_-_22337204 0.24 ENST00000430142.1
ENST00000357179.5
TOP3B
topoisomerase (DNA) III beta
chr7_+_45927956 0.23 ENST00000275525.3
ENST00000457280.1
IGFBP1
insulin-like growth factor binding protein 1
chr22_+_31002990 0.23 ENST00000423350.1
TCN2
transcobalamin II
chr4_-_109541539 0.23 ENST00000509984.1
ENST00000507248.1
ENST00000506795.1
RPL34-AS1
RPL34 antisense RNA 1 (head to head)
chr16_+_22524379 0.23 ENST00000536620.1
NPIPB5
nuclear pore complex interacting protein family, member B5
chr2_+_175199674 0.22 ENST00000394967.2
SP9
Sp9 transcription factor
chr19_+_29097595 0.22 ENST00000587961.1
AC079466.1
AC079466.1
chr4_-_987217 0.22 ENST00000361661.2
ENST00000398516.2
SLC26A1
solute carrier family 26 (anion exchanger), member 1
chr16_-_57831676 0.22 ENST00000465878.2
ENST00000539578.1
ENST00000561524.1
KIFC3
kinesin family member C3
chr4_+_155484103 0.20 ENST00000302068.4
FGB
fibrinogen beta chain
chrX_+_120181457 0.20 ENST00000328078.1
GLUD2
glutamate dehydrogenase 2
chr8_-_124749609 0.19 ENST00000262219.6
ENST00000419625.1
ANXA13
annexin A13
chrX_+_99899180 0.19 ENST00000373004.3
SRPX2
sushi-repeat containing protein, X-linked 2
chr21_-_19775973 0.18 ENST00000284885.3
TMPRSS15
transmembrane protease, serine 15
chr22_-_30970498 0.18 ENST00000431313.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr6_+_144665237 0.18 ENST00000421035.2
UTRN
utrophin
chrX_+_48660107 0.18 ENST00000376643.2
HDAC6
histone deacetylase 6
chr6_+_54173227 0.17 ENST00000259782.4
ENST00000370864.3
TINAG
tubulointerstitial nephritis antigen
chr10_-_38146482 0.17 ENST00000374648.3
ZNF248
zinc finger protein 248
chr1_-_36020531 0.16 ENST00000440579.1
ENST00000494948.1
KIAA0319L
KIAA0319-like
chr10_+_115312766 0.16 ENST00000351270.3
HABP2
hyaluronan binding protein 2
chr17_-_64225508 0.16 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr6_-_127840336 0.16 ENST00000525778.1
SOGA3
SOGA family member 3
chr15_+_67418047 0.16 ENST00000540846.2
SMAD3
SMAD family member 3
chr16_-_20587599 0.16 ENST00000566384.1
ENST00000565232.1
ENST00000567001.1
ENST00000565322.1
ENST00000569344.1
ENST00000329697.6
ENST00000414188.2
ENST00000568882.1
ACSM2B
acyl-CoA synthetase medium-chain family member 2B
chr4_-_69434245 0.16 ENST00000317746.2
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B17
chr9_+_130860810 0.16 ENST00000433501.1
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr3_-_169587621 0.16 ENST00000523069.1
ENST00000316428.5
ENST00000264676.5
LRRC31
leucine rich repeat containing 31
chr1_+_207277632 0.15 ENST00000421786.1
C4BPA
complement component 4 binding protein, alpha
chr9_+_130860583 0.15 ENST00000373064.5
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr18_+_61445205 0.15 ENST00000431370.1
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr22_-_38506619 0.14 ENST00000332536.5
ENST00000381669.3
BAIAP2L2
BAI1-associated protein 2-like 2
chr6_-_161085291 0.14 ENST00000316300.5
LPA
lipoprotein, Lp(a)
chr19_+_6464502 0.14 ENST00000308243.7
CRB3
crumbs homolog 3 (Drosophila)
chr6_-_127840021 0.14 ENST00000465909.2
SOGA3
SOGA family member 3
chr5_+_40841410 0.14 ENST00000381677.3
CARD6
caspase recruitment domain family, member 6
chr4_-_110723194 0.13 ENST00000394635.3
CFI
complement factor I
chr19_+_41305085 0.13 ENST00000303961.4
EGLN2
egl-9 family hypoxia-inducible factor 2
chr3_+_66271410 0.13 ENST00000336733.6
SLC25A26
solute carrier family 25 (S-adenosylmethionine carrier), member 26
chr10_-_61495760 0.13 ENST00000395347.1
SLC16A9
solute carrier family 16, member 9
chr10_+_5135981 0.12 ENST00000380554.3
AKR1C3
aldo-keto reductase family 1, member C3
chr14_+_24590560 0.12 ENST00000558325.1
RP11-468E2.6
RP11-468E2.6
chr9_-_98079965 0.12 ENST00000289081.3
FANCC
Fanconi anemia, complementation group C
chr20_+_62371206 0.12 ENST00000266077.2
SLC2A4RG
SLC2A4 regulator
chr12_+_40787194 0.11 ENST00000425730.2
ENST00000454784.4
MUC19
mucin 19, oligomeric
chr1_+_162351503 0.11 ENST00000458626.2
C1orf226
chromosome 1 open reading frame 226
chr6_-_25874440 0.11 ENST00000361703.6
ENST00000397060.4
SLC17A3
solute carrier family 17 (organic anion transporter), member 3
chr17_+_79953310 0.11 ENST00000582355.2
ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr7_-_47579188 0.11 ENST00000398879.1
ENST00000355730.3
ENST00000442536.2
ENST00000458317.2
TNS3
tensin 3
chr19_-_11639910 0.11 ENST00000588998.1
ENST00000586149.1
ECSIT
ECSIT signalling integrator
chr8_-_17752996 0.11 ENST00000381841.2
ENST00000427924.1
FGL1
fibrinogen-like 1
chr2_-_99917639 0.11 ENST00000308528.4
LYG1
lysozyme G-like 1
chr9_-_13165457 0.11 ENST00000542239.1
ENST00000538841.1
ENST00000433359.2
MPDZ
multiple PDZ domain protein
chr4_+_14113592 0.11 ENST00000502759.1
ENST00000511200.1
ENST00000512754.1
ENST00000506739.1
LINC01085
long intergenic non-protein coding RNA 1085
chr6_-_117747015 0.11 ENST00000368508.3
ENST00000368507.3
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chr3_-_126327398 0.10 ENST00000383572.2
TXNRD3NB
thioredoxin reductase 3 neighbor
chr5_+_176513895 0.10 ENST00000503708.1
ENST00000393648.2
ENST00000514472.1
ENST00000502906.1
ENST00000292410.3
ENST00000510911.1
FGFR4
fibroblast growth factor receptor 4
chr8_+_42873548 0.10 ENST00000533338.1
ENST00000534420.1
HOOK3
RP11-598P20.5
hook microtubule-tethering protein 3
Uncharacterized protein
chr17_+_48823896 0.10 ENST00000511974.1
LUC7L3
LUC7-like 3 (S. cerevisiae)
chr5_+_176513868 0.10 ENST00000292408.4
FGFR4
fibroblast growth factor receptor 4
chr17_+_35732916 0.10 ENST00000586700.1
C17orf78
chromosome 17 open reading frame 78
chr4_-_102267953 0.10 ENST00000523694.2
ENST00000507176.1
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chrX_-_124097620 0.10 ENST00000371130.3
ENST00000422452.2
TENM1
teneurin transmembrane protein 1
chr16_+_20775024 0.10 ENST00000289416.5
ACSM3
acyl-CoA synthetase medium-chain family member 3
chr16_-_420514 0.10 ENST00000199706.8
MRPL28
mitochondrial ribosomal protein L28
chr3_+_141043050 0.09 ENST00000509842.1
ZBTB38
zinc finger and BTB domain containing 38
chr8_+_55047763 0.09 ENST00000260102.4
ENST00000519831.1
MRPL15
mitochondrial ribosomal protein L15
chr5_-_77844974 0.09 ENST00000515007.2
LHFPL2
lipoma HMGIC fusion partner-like 2
chr9_-_94712434 0.09 ENST00000375708.3
ROR2
receptor tyrosine kinase-like orphan receptor 2
chr1_+_207262627 0.09 ENST00000391923.1
C4BPB
complement component 4 binding protein, beta
chr11_-_128894053 0.09 ENST00000392657.3
ARHGAP32
Rho GTPase activating protein 32
chr1_+_205197304 0.08 ENST00000358024.3
TMCC2
transmembrane and coiled-coil domain family 2
chr4_+_155484155 0.08 ENST00000509493.1
FGB
fibrinogen beta chain
chr10_-_52645416 0.08 ENST00000374001.2
ENST00000373997.3
ENST00000373995.3
ENST00000282641.2
ENST00000395495.1
ENST00000414883.1
A1CF
APOBEC1 complementation factor
chr4_-_129208030 0.08 ENST00000503872.1
PGRMC2
progesterone receptor membrane component 2
chr12_-_56615693 0.07 ENST00000394013.2
ENST00000345093.4
ENST00000551711.1
ENST00000552656.1
RNF41
ring finger protein 41
chr12_-_102874416 0.07 ENST00000392904.1
ENST00000337514.6
IGF1
insulin-like growth factor 1 (somatomedin C)
chr7_-_122840015 0.07 ENST00000194130.2
SLC13A1
solute carrier family 13 (sodium/sulfate symporter), member 1
chr5_+_40841276 0.06 ENST00000254691.5
CARD6
caspase recruitment domain family, member 6
chr1_-_207206092 0.06 ENST00000359470.5
ENST00000461135.2
C1orf116
chromosome 1 open reading frame 116
chr5_+_68860949 0.06 ENST00000507595.1
GTF2H2C
general transcription factor IIH, polypeptide 2C
chr17_+_48823975 0.06 ENST00000513969.1
ENST00000503728.1
LUC7L3
LUC7-like 3 (S. cerevisiae)
chr11_+_2405833 0.06 ENST00000527343.1
ENST00000464784.2
CD81
CD81 molecule
chr14_-_54425475 0.06 ENST00000559642.1
BMP4
bone morphogenetic protein 4
chr10_+_111765562 0.06 ENST00000360162.3
ADD3
adducin 3 (gamma)
chr7_-_87856303 0.06 ENST00000394641.3
SRI
sorcin
chr4_-_129207942 0.05 ENST00000503588.1
PGRMC2
progesterone receptor membrane component 2
chr8_-_87242589 0.05 ENST00000419776.2
ENST00000297524.3
SLC7A13
solute carrier family 7 (anionic amino acid transporter), member 13
chr4_+_100495864 0.05 ENST00000265517.5
ENST00000422897.2
MTTP
microsomal triglyceride transfer protein
chr6_+_167704798 0.05 ENST00000230256.3
UNC93A
unc-93 homolog A (C. elegans)
chr22_-_27456361 0.05 ENST00000453934.1
CTA-992D9.6
CTA-992D9.6
chr7_+_130126012 0.05 ENST00000341441.5
MEST
mesoderm specific transcript
chr7_+_141695671 0.05 ENST00000497673.1
ENST00000475668.2
MGAM
maltase-glucoamylase (alpha-glucosidase)
chr7_+_45928079 0.05 ENST00000468955.1
IGFBP1
insulin-like growth factor binding protein 1
chr16_+_20775358 0.05 ENST00000440284.2
ACSM3
acyl-CoA synthetase medium-chain family member 3
chr12_+_100867486 0.04 ENST00000548884.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr4_-_22444733 0.04 ENST00000508133.1
GPR125
G protein-coupled receptor 125
chr17_-_36904437 0.04 ENST00000585100.1
ENST00000360797.2
ENST00000578109.1
ENST00000579882.1
PCGF2
polycomb group ring finger 2
chr1_+_207262578 0.04 ENST00000243611.5
ENST00000367076.3
C4BPB
complement component 4 binding protein, beta
chr6_+_106534192 0.04 ENST00000369091.2
ENST00000369096.4
PRDM1
PR domain containing 1, with ZNF domain
chr16_-_57832004 0.04 ENST00000562503.1
KIFC3
kinesin family member C3
chr5_-_138718973 0.04 ENST00000353963.3
ENST00000348729.3
SLC23A1
solute carrier family 23 (ascorbic acid transporter), member 1
chr3_+_180319918 0.04 ENST00000296015.4
ENST00000491380.1
ENST00000412756.2
ENST00000382584.4
TTC14
tetratricopeptide repeat domain 14
chr4_-_110723134 0.04 ENST00000510800.1
ENST00000512148.1
CFI
complement factor I
chr11_-_65149422 0.04 ENST00000526432.1
ENST00000527174.1
SLC25A45
solute carrier family 25, member 45
chr7_+_23749767 0.04 ENST00000355870.3
STK31
serine/threonine kinase 31
chr1_+_36789335 0.03 ENST00000373137.2
RP11-268J15.5
RP11-268J15.5
chr7_-_47578840 0.03 ENST00000450444.1
TNS3
tensin 3
chr22_+_31002779 0.03 ENST00000215838.3
TCN2
transcobalamin II
chr3_+_72200408 0.03 ENST00000473713.1
LINC00870
long intergenic non-protein coding RNA 870
chr6_+_131571535 0.03 ENST00000474850.2
AKAP7
A kinase (PRKA) anchor protein 7
chr17_+_68071389 0.03 ENST00000283936.1
ENST00000392671.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr22_+_31003190 0.02 ENST00000407817.3
TCN2
transcobalamin II
chr4_-_74486109 0.02 ENST00000395777.2
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr4_-_74486217 0.02 ENST00000335049.5
ENST00000307439.5
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr8_+_104892639 0.02 ENST00000436393.2
RIMS2
regulating synaptic membrane exocytosis 2
chr12_-_102874378 0.02 ENST00000456098.1
IGF1
insulin-like growth factor 1 (somatomedin C)
chr1_-_153585539 0.02 ENST00000368706.4
S100A16
S100 calcium binding protein A16
chr4_-_70518941 0.02 ENST00000286604.4
ENST00000505512.1
ENST00000514019.1
UGT2A1
UGT2A1
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
chr12_+_100867733 0.02 ENST00000546380.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr4_-_100212132 0.02 ENST00000209668.2
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr16_-_420338 0.02 ENST00000450882.1
ENST00000441883.1
ENST00000447696.1
ENST00000389675.2
MRPL28
mitochondrial ribosomal protein L28
chr11_+_20620946 0.02 ENST00000525748.1
SLC6A5
solute carrier family 6 (neurotransmitter transporter), member 5
chr19_-_36304201 0.02 ENST00000301175.3
PRODH2
proline dehydrogenase (oxidase) 2
chr12_+_100867694 0.02 ENST00000392986.3
ENST00000549996.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr20_+_45947246 0.02 ENST00000599904.1
AL031666.2
HCG2018772; Uncharacterized protein; cDNA FLJ31609 fis, clone NT2RI2002852
chr12_+_60058458 0.02 ENST00000548610.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7

Network of associatons between targets according to the STRING database.

First level regulatory network of HNF1A_HNF1B

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.2 2.7 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 0.6 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.1 0.8 GO:1903412 response to bile acid(GO:1903412)
0.1 0.4 GO:0060738 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908) positive regulation of immature T cell proliferation in thymus(GO:0033092) right lung development(GO:0060458) primary prostatic bud elongation(GO:0060516) epithelial-mesenchymal signaling involved in prostate gland development(GO:0060738) sclerotome development(GO:0061056)
0.1 1.2 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.1 0.6 GO:0051958 methotrexate transport(GO:0051958)
0.1 0.3 GO:0090675 intermicrovillar adhesion(GO:0090675)
0.1 0.4 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.1 0.4 GO:0033625 positive regulation of integrin activation(GO:0033625)
0.1 0.3 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) isoquinoline alkaloid metabolic process(GO:0033076)
0.1 0.3 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
0.1 0.3 GO:1904106 protein localization to microvillus(GO:1904106)
0.1 0.7 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 0.4 GO:0019470 4-hydroxyproline catabolic process(GO:0019470)
0.0 0.2 GO:0070844 misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)
0.0 0.4 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.1 GO:2000224 sesquiterpenoid metabolic process(GO:0006714) sesquiterpenoid catabolic process(GO:0016107) farnesol metabolic process(GO:0016487) farnesol catabolic process(GO:0016488) regulation of testosterone biosynthetic process(GO:2000224)
0.0 0.3 GO:0000023 maltose metabolic process(GO:0000023)
0.0 0.7 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.1 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.0 0.3 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.5 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.1 GO:0015860 purine nucleoside transmembrane transport(GO:0015860)
0.0 0.3 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0 0.1 GO:0010615 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) positive regulation of connective tissue replacement(GO:1905205)
0.0 0.6 GO:0006265 DNA topological change(GO:0006265)
0.0 0.8 GO:0060065 uterus development(GO:0060065)
0.0 0.2 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.0 0.2 GO:0034036 purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.0 0.1 GO:0010966 regulation of phosphate transport(GO:0010966)
0.0 0.3 GO:0090204 protein localization to nuclear pore(GO:0090204)
0.0 0.2 GO:0006538 glutamate catabolic process(GO:0006538)
0.0 0.3 GO:0015866 ADP transport(GO:0015866)
0.0 0.6 GO:2000651 positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.0 0.1 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.1 GO:1900020 embryonic genitalia morphogenesis(GO:0030538) regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.0 0.5 GO:0051180 vitamin transport(GO:0051180)
0.0 0.1 GO:0030450 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959)
0.0 0.1 GO:0034378 chylomicron assembly(GO:0034378)
0.0 0.0 GO:1990654 sebum secreting cell proliferation(GO:1990654)
0.0 0.7 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 0.1 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.1 GO:0061149 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.0 0.3 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.1 GO:0043128 regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043126) positive regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043128)
0.0 0.3 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.1 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0070931 Golgi-associated vesicle lumen(GO:0070931)
0.1 0.3 GO:1990666 PCSK9-LDLR complex(GO:1990666)
0.1 0.3 GO:0044214 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.1 0.4 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.6 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.7 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.7 GO:0005915 zonula adherens(GO:0005915)
0.0 0.5 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.1 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0 0.2 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.1 GO:0070695 FHF complex(GO:0070695)
0.0 0.1 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0019770 IgG receptor activity(GO:0019770)
0.3 2.7 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.1 0.4 GO:0004522 ribonuclease A activity(GO:0004522)
0.1 0.4 GO:0015322 proton-dependent oligopeptide secondary active transmembrane transporter activity(GO:0005427) secondary active oligopeptide transmembrane transporter activity(GO:0015322)
0.1 0.6 GO:0015350 methotrexate transporter activity(GO:0015350)
0.1 0.4 GO:0008431 vitamin E binding(GO:0008431)
0.1 0.7 GO:0030274 LIM domain binding(GO:0030274)
0.1 0.3 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.1 0.4 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.1 0.6 GO:0071253 connexin binding(GO:0071253)
0.1 0.8 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 0.6 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.1 0.4 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.1 0.3 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.2 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.0 0.1 GO:0047017 geranylgeranyl reductase activity(GO:0045550) prostaglandin-F synthase activity(GO:0047017)
0.0 0.4 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.2 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.3 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558) maltose alpha-glucosidase activity(GO:0032450)
0.0 0.7 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.3 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.2 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.0 0.3 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.7 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.2 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.0 0.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 1.1 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.5 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.3 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 0.1 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.1 GO:0005501 retinoic acid binding(GO:0001972) retinoid binding(GO:0005501) isoprenoid binding(GO:0019840)
0.0 0.1 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.1 GO:0019826 oxygen sensor activity(GO:0019826)
0.0 0.0 GO:0008520 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.0 0.1 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 ST STAT3 PATHWAY STAT3 Pathway
0.0 2.2 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.8 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 1.7 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 2.7 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.4 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 1.2 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.3 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.5 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.7 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.3 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.6 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport