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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for HNF1A_HNF1B
Z-value: 1.82
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Transcription factors associated with HNF1A_HNF1B
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HNF1A | hg19_v2_chr12_+_121416437_121416479 | 0.95 | 4.6e-02 | Click! |
| HNF1B | hg19_v2_chr17_-_36105009_36105060 | 0.76 | 2.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_204183071 Show fit | 1.55 |
ENST00000308302.3
|
golgi transport 1A |
|
| chr17_+_4692230 Show fit | 1.53 |
ENST00000331264.7
|
glycolipid transfer protein domain containing 2 |
|
| chr17_+_73642315 Show fit | 1.33 |
ENST00000556126.2
|
small integral membrane protein 6 |
|
| chr2_-_87248975 Show fit | 1.32 |
ENST00000409310.2
ENST00000355705.3 |
plasminogen-like B1 |
|
| chr17_+_73642486 Show fit | 1.09 |
ENST00000579469.1
|
small integral membrane protein 6 |
|
| chr2_-_47572207 Show fit | 0.88 |
ENST00000441997.1
|
AC073283.4 |
|
| chr22_-_30970560 Show fit | 0.86 |
ENST00000402369.1
ENST00000406361.1 |
galactose-3-O-sulfotransferase 1 |
|
| chr3_+_187930429 Show fit | 0.86 |
ENST00000420410.1
|
LIM domain containing preferred translocation partner in lipoma |
|
| chr22_-_30968839 Show fit | 0.86 |
ENST00000445645.1
ENST00000416358.1 ENST00000423371.1 ENST00000411821.1 ENST00000448604.1 |
galactose-3-O-sulfotransferase 1 |
|
| chr1_-_168464875 Show fit | 0.86 |
ENST00000422253.1
|
RP5-968D22.3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HNF1A_HNF1B
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.7 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.5 | 1.5 | GO:0002416 | IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416) |
| 0.1 | 1.2 | GO:2000189 | positive regulation of cholesterol homeostasis(GO:2000189) |
| 0.1 | 0.8 | GO:1903412 | response to bile acid(GO:1903412) |
| 0.0 | 0.8 | GO:0060065 | uterus development(GO:0060065) |
| 0.1 | 0.7 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 0.0 | 0.7 | GO:1990573 | potassium ion import across plasma membrane(GO:1990573) |
| 0.0 | 0.7 | GO:0045744 | negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744) |
| 0.1 | 0.6 | GO:0071393 | cellular response to progesterone stimulus(GO:0071393) |
| 0.1 | 0.6 | GO:0051958 | methotrexate transport(GO:0051958) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.0 | 0.7 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.0 | 0.6 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 0.5 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.1 | 0.4 | GO:0070931 | Golgi-associated vesicle lumen(GO:0070931) |
| 0.1 | 0.4 | GO:0032311 | angiogenin-PRI complex(GO:0032311) |
| 0.1 | 0.3 | GO:1990666 | PCSK9-LDLR complex(GO:1990666) |
| 0.1 | 0.3 | GO:0044214 | spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717) |
| 0.0 | 0.2 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.0 | 0.1 | GO:0035867 | alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.7 | GO:0001733 | galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694) |
| 0.3 | 1.5 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 0.0 | 1.1 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.1 | 0.8 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.1 | 0.7 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.0 | 0.7 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 0.0 | 0.7 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.1 | 0.6 | GO:0015350 | methotrexate transporter activity(GO:0015350) |
| 0.1 | 0.6 | GO:0071253 | connexin binding(GO:0071253) |
| 0.1 | 0.6 | GO:0003917 | DNA topoisomerase type I activity(GO:0003917) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 1.7 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.8 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.6 | ST STAT3 PATHWAY | STAT3 Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.7 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 1.4 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.0 | 1.2 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.1 | 0.8 | REACTOME FGFR4 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.0 | 0.7 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.7 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 0.6 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.0 | 0.5 | REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 0.0 | 0.5 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.3 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |