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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for HLF_TEF
Z-value: 0.97
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Transcription factors associated with HLF_TEF
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HLF | hg19_v2_chr17_+_53345080_53345177 | -1.00 | 1.5e-03 | Click! |
| TEF | hg19_v2_chr22_+_41763274_41763337 | 0.08 | 9.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_-_34665983 Show fit | 1.37 |
ENST00000416454.1
ENST00000544078.2 ENST00000421828.2 ENST00000423809.1 |
HCG2040265, isoform CRA_a; Uncharacterized protein; cDNA FLJ50015 |
|
| chr20_+_4667094 Show fit | 0.67 |
ENST00000424424.1
ENST00000457586.1 |
prion protein |
|
| chr12_-_46121554 Show fit | 0.59 |
ENST00000609803.1
|
long intergenic non-protein coding RNA 938 |
|
| chr14_+_78227105 Show fit | 0.57 |
ENST00000439131.2
ENST00000355883.3 ENST00000557011.1 ENST00000556047.1 |
chromosome 14 open reading frame 178 |
|
| chr8_+_94752349 Show fit | 0.42 |
ENST00000391680.1
|
RBM12B antisense RNA 1 |
|
| chr1_+_7844312 Show fit | 0.41 |
ENST00000377541.1
|
period circadian clock 3 |
|
| chr13_-_29292956 Show fit | 0.41 |
ENST00000266943.6
|
solute carrier family 46, member 3 |
|
| chr8_-_27469383 Show fit | 0.41 |
ENST00000519742.1
|
clusterin |
|
| chr8_-_102218292 Show fit | 0.40 |
ENST00000518336.1
ENST00000520454.1 |
zinc finger protein 706 |
|
| chr12_-_12714006 Show fit | 0.39 |
ENST00000541207.1
|
dual specificity phosphatase 16 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HLF_TEF
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.8 | GO:0045209 | MAPK phosphatase export from nucleus(GO:0045208) MAPK phosphatase export from nucleus, leptomycin B sensitive(GO:0045209) |
| 0.1 | 0.7 | GO:0000821 | regulation of arginine metabolic process(GO:0000821) basic amino acid transmembrane transport(GO:1990822) |
| 0.2 | 0.6 | GO:1990535 | neuron projection maintenance(GO:1990535) |
| 0.0 | 0.6 | GO:1902455 | negative regulation of stem cell population maintenance(GO:1902455) |
| 0.1 | 0.4 | GO:1903045 | neural crest cell migration involved in sympathetic nervous system development(GO:1903045) |
| 0.0 | 0.4 | GO:0043435 | response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376) |
| 0.0 | 0.4 | GO:0045187 | regulation of circadian sleep/wake cycle(GO:0042749) regulation of circadian sleep/wake cycle, sleep(GO:0045187) |
| 0.0 | 0.3 | GO:1903764 | regulation of potassium ion export across plasma membrane(GO:1903764) |
| 0.0 | 0.3 | GO:0040033 | miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974) regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) |
| 0.0 | 0.3 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0043219 | lateral loop(GO:0043219) |
| 0.0 | 0.4 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.0 | 0.2 | GO:0070110 | ciliary neurotrophic factor receptor complex(GO:0070110) |
| 0.0 | 0.2 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.0 | 0.2 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.0 | 0.2 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.0 | 0.1 | GO:0071942 | XPC complex(GO:0071942) |
| 0.0 | 0.1 | GO:0001674 | female germ cell nucleus(GO:0001674) |
| 0.0 | 0.1 | GO:0097452 | GAIT complex(GO:0097452) |
| 0.0 | 0.1 | GO:0016272 | prefoldin complex(GO:0016272) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 0.7 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
| 0.1 | 0.6 | GO:1903135 | cupric ion binding(GO:1903135) |
| 0.1 | 0.5 | GO:0004882 | androgen receptor activity(GO:0004882) |
| 0.1 | 0.4 | GO:0004947 | bradykinin receptor activity(GO:0004947) |
| 0.0 | 0.4 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.0 | 0.3 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.1 | 0.2 | GO:0070119 | ciliary neurotrophic factor binding(GO:0070119) |
| 0.0 | 0.2 | GO:0047256 | beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256) |
| 0.0 | 0.2 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.0 | 0.6 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 0.3 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 0.5 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.0 | 0.4 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 0.4 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.2 | REACTOME OPSINS | Genes involved in Opsins |