ISMARA results: HIC2

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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for HIC2

Z-value: 3.55

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Transcription factors associated with HIC2

Gene Symbol	Gene ID	Gene Info
HIC2 Ensembl NCBI GeneCards UniProt	ENSG00000169635.5	HIC ZBTB transcriptional repressor 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HIC2	hg19_v2_chr22_+_21771656_21771693	0.82	1.8e-01	Click!

Activity profile of HIC2 motif

Sorted Z-values of HIC2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_-_55895966 Show fit	3.45	ENST00000444469.3	TMEM238 Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 238
chrX_-_153279697 Show fit	2.46	ENST00000444254.1	IRAK1 Ensembl NCBI GeneCards UniProt Show fit	interleukin-1 receptor-associated kinase 1
chr19_+_54496132 Show fit	2.39	ENST00000346968.2	CACNG6 Ensembl NCBI GeneCards UniProt Show fit	calcium channel, voltage-dependent, gamma subunit 6
chr15_+_90735145 Show fit	2.13	ENST00000559792.1	SEMA4B Ensembl NCBI GeneCards UniProt Show fit	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr16_-_18441131 Show fit	2.03	ENST00000339303.5	NPIPA8 Ensembl NCBI GeneCards UniProt Show fit	nuclear pore complex interacting protein family, member A8
chr16_+_771663 Show fit	1.96	ENST00000568916.1	FAM173A Ensembl NCBI GeneCards UniProt Show fit	family with sequence similarity 173, member A
chr16_+_50308028 Show fit	1.93	ENST00000566761.2	ADCY7 Ensembl NCBI GeneCards UniProt Show fit	adenylate cyclase 7
chr15_+_76030311 Show fit	1.80	ENST00000543887.1	AC019294.1 Ensembl NCBI GeneCards UniProt Show fit	AC019294.1
chr11_+_392587 Show fit	1.79	ENST00000534401.1	PKP3 Ensembl NCBI GeneCards UniProt Show fit	plakophilin 3
chr17_+_73606766 Show fit	1.76	ENST00000578462.1	MYO15B Ensembl NCBI GeneCards UniProt Show fit	myosin XVB pseudogene

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HIC2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	4.2	GO:0009439	cyanate metabolic process(GO:0009439) cyanate catabolic process(GO:0009440)
0.1	2.6	GO:0007250	activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.3	2.5	GO:0038003	opioid receptor signaling pathway(GO:0038003)
0.1	2.5	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.0	2.5	GO:0006958	complement activation, classical pathway(GO:0006958)
0.3	2.4	GO:0060480	lung goblet cell differentiation(GO:0060480) lobar bronchus epithelium development(GO:0060481)
0.1	2.4	GO:0015893	drug transport(GO:0015893)
0.0	2.4	GO:1901385	regulation of voltage-gated calcium channel activity(GO:1901385)
0.5	2.3	GO:0038098	sequestering of BMP from receptor via BMP binding(GO:0038098)
0.3	2.1	GO:0031914	negative regulation of synaptic plasticity(GO:0031914)

Showing 1 to 10 of 454 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.7	GO:0035578	azurophil granule lumen(GO:0035578)
0.4	2.5	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.0	2.5	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.1	2.4	GO:0030057	desmosome(GO:0030057)
0.0	2.4	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)
0.0	2.3	GO:0031985	Golgi cisterna(GO:0031985)
0.0	2.2	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.1	2.1	GO:0008074	guanylate cyclase complex, soluble(GO:0008074)
0.1	2.0	GO:0000813	ESCRT I complex(GO:0000813)
0.4	1.9	GO:0002133	polycystin complex(GO:0002133)

Showing 1 to 10 of 164 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	8.5	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0	5.2	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.7	4.2	GO:0004792	thiosulfate sulfurtransferase activity(GO:0004792)
0.1	3.7	GO:0050699	WW domain binding(GO:0050699)
0.2	3.3	GO:0097493	structural molecule activity conferring elasticity(GO:0097493)
0.5	2.7	GO:0008665	2'-phosphotransferase activity(GO:0008665)
0.3	2.5	GO:0004704	NF-kappaB-inducing kinase activity(GO:0004704)
0.2	2.5	GO:0016015	morphogen activity(GO:0016015)
0.0	2.5	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.1	2.4	GO:0045294	alpha-catenin binding(GO:0045294)

Showing 1 to 10 of 311 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.7	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.0	2.9	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.0	2.3	NABA COLLAGENS	Genes encoding collagen proteins
0.0	2.2	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	2.0	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	1.8	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	1.7	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	1.6	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0	1.5	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0	1.5	PID ATM PATHWAY	ATM pathway

Showing 1 to 10 of 32 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.0	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	3.0	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.1	2.2	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
0.1	2.2	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.1	2.1	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0	2.0	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.1	1.9	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1	1.9	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.0	1.9	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.1	1.8	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins

Showing 1 to 10 of 73 entries

Results for HIC2

Z-value: 3.55

Motif logo

Transcription factors associated with HIC2

Activity-expression correlation:

Activity profile of HIC2 motif

Sorted Z-values of HIC2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HIC2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: