ISMARA results: GTF2I

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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for GTF2I

Z-value: 2.23

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Transcription factors associated with GTF2I

Gene Symbol	Gene ID	Gene Info
GTF2I Ensembl NCBI GeneCards UniProt	ENSG00000077809.8	general transcription factor IIi

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GTF2I	hg19_v2_chr7_+_74072288_74072357	-0.45	5.5e-01	Click!

Activity profile of GTF2I motif

Sorted Z-values of GTF2I motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_219264466 Show fit	2.83	ENST00000273062.2	CTDSP1 Ensembl NCBI GeneCards UniProt Show fit	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr19_+_50094866 Show fit	2.13	ENST00000418929.2	PRR12 Ensembl NCBI GeneCards UniProt Show fit	proline rich 12
chr19_-_46272462 Show fit	1.82	ENST00000317578.6	SIX5 Ensembl NCBI GeneCards UniProt Show fit	SIX homeobox 5
chr16_+_30935418 Show fit	1.79	ENST00000338343.4	FBXL19 Ensembl NCBI GeneCards UniProt Show fit	F-box and leucine-rich repeat protein 19
chr1_-_167906020 Show fit	1.53	ENST00000458574.1	MPC2 Ensembl NCBI GeneCards UniProt Show fit	mitochondrial pyruvate carrier 2
chr7_+_5465382 Show fit	1.41	ENST00000609130.1	RP11-1275H24.2 Ensembl NCBI GeneCards UniProt Show fit	RP11-1275H24.2
chr16_+_29819446 Show fit	1.41	ENST00000568282.1	MAZ Ensembl NCBI GeneCards UniProt Show fit	MYC-associated zinc finger protein (purine-binding transcription factor)
chr11_+_394145 Show fit	1.39	ENST00000528036.1	PKP3 Ensembl NCBI GeneCards UniProt Show fit	plakophilin 3
chr5_+_149865838 Show fit	1.35	ENST00000519157.1	NDST1 Ensembl NCBI GeneCards UniProt Show fit	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr5_+_149865377 Show fit	1.33	ENST00000522491.1	NDST1 Ensembl NCBI GeneCards UniProt Show fit	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of GTF2I

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.9	GO:1902807	negative regulation of cell cycle G1/S phase transition(GO:1902807)
1.0	3.0	GO:0014859	negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723)
0.2	2.8	GO:0006477	protein sulfation(GO:0006477)
0.0	2.6	GO:0006369	termination of RNA polymerase II transcription(GO:0006369)
0.1	2.3	GO:0046341	CDP-diacylglycerol metabolic process(GO:0046341)
0.2	2.2	GO:0002159	desmosome assembly(GO:0002159)
0.3	1.9	GO:0042986	positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.2	1.9	GO:0048295	positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.3	1.8	GO:0061086	negative regulation of histone H3-K27 methylation(GO:0061086)
0.2	1.8	GO:0035279	mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)

Showing 1 to 10 of 293 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.1	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.2	2.8	GO:0005677	chromatin silencing complex(GO:0005677)
0.3	2.7	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.4	2.2	GO:0097129	cyclin D2-CDK4 complex(GO:0097129)
0.1	2.1	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.1	1.7	GO:0061689	tricellular tight junction(GO:0061689)
0.1	1.7	GO:0031304	intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0	1.7	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.0	1.6	GO:0005747	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0	1.6	GO:0032580	Golgi cisterna membrane(GO:0032580)

Showing 1 to 10 of 105 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	3.5	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	3.3	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.4	2.9	GO:0050119	N-acetylglucosamine deacetylase activity(GO:0050119)
0.1	2.8	GO:0017075	syntaxin-1 binding(GO:0017075)
0.3	2.3	GO:0004969	histamine receptor activity(GO:0004969)
0.1	2.2	GO:0045294	alpha-catenin binding(GO:0045294)
0.1	2.1	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.0	2.1	GO:0005109	frizzled binding(GO:0005109)
0.0	2.1	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.2	1.6	GO:0050833	pyruvate transmembrane transporter activity(GO:0050833)

Showing 1 to 10 of 175 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.2	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1	2.1	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	1.9	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.0	1.3	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	1.3	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	1.3	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.0	1.2	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.0	1.1	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	1.0	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
0.0	0.8	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin

Showing 1 to 10 of 29 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.2	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	2.4	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.0	1.7	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.0	1.4	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	1.4	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	1.4	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.1	1.3	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0	1.3	REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS	Genes involved in Glycerophospholipid biosynthesis
0.0	1.1	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0	1.0	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling

Showing 1 to 10 of 43 entries

Results for GTF2I

Z-value: 2.23

Motif logo

Transcription factors associated with GTF2I

Activity-expression correlation:

Activity profile of GTF2I motif

Sorted Z-values of GTF2I motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of GTF2I

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: