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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for GLI3
Z-value: 1.86
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Transcription factors associated with GLI3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GLI3 | hg19_v2_chr7_-_42276612_42276782 | -0.75 | 2.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_50148087 Show fit | 1.59 |
ENST00000601038.1
ENST00000595242.1 |
SR-related CTD-associated factor 1 |
|
| chr19_-_46145696 Show fit | 1.22 |
ENST00000588172.1
|
echinoderm microtubule associated protein like 2 |
|
| chr19_+_51152702 Show fit | 1.20 |
ENST00000425202.1
|
chromosome 19 open reading frame 81 |
|
| chr16_+_29832634 Show fit | 0.97 |
ENST00000565164.1
ENST00000570234.1 |
major vault protein |
|
| chr19_-_30199516 Show fit | 0.97 |
ENST00000591243.1
|
chromosome 19 open reading frame 12 |
|
| chr19_-_50381606 Show fit | 0.93 |
ENST00000391830.1
|
AKT1 substrate 1 (proline-rich) |
|
| chr7_+_76101379 Show fit | 0.92 |
ENST00000429179.1
|
deltex homolog 2 (Drosophila) |
|
| chr11_+_76493294 Show fit | 0.92 |
ENST00000533752.1
|
tsukushi, small leucine rich proteoglycan |
|
| chr16_+_70695570 Show fit | 0.86 |
ENST00000597002.1
|
FLJ00418 |
|
| chr20_+_62327996 Show fit | 0.85 |
ENST00000369996.1
|
tumor necrosis factor receptor superfamily, member 6b, decoy |
Network of associatons between targets according to the STRING database.
First level regulatory network of GLI3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.0 | GO:0006049 | UDP-N-acetylglucosamine catabolic process(GO:0006049) |
| 0.0 | 1.8 | GO:0048011 | neurotrophin TRK receptor signaling pathway(GO:0048011) |
| 0.0 | 1.6 | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) |
| 0.1 | 1.2 | GO:0010968 | regulation of microtubule nucleation(GO:0010968) |
| 0.1 | 1.1 | GO:0007386 | compartment pattern specification(GO:0007386) |
| 0.1 | 1.1 | GO:0032926 | negative regulation of activin receptor signaling pathway(GO:0032926) |
| 0.0 | 1.1 | GO:0045839 | negative regulation of mitotic nuclear division(GO:0045839) |
| 0.0 | 1.0 | GO:0031953 | negative regulation of protein autophosphorylation(GO:0031953) |
| 0.3 | 0.9 | GO:0061073 | ciliary body morphogenesis(GO:0061073) |
| 0.1 | 0.9 | GO:0002159 | desmosome assembly(GO:0002159) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | GO:0044306 | neuron projection terminus(GO:0044306) |
| 0.1 | 1.0 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.0 | 1.0 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.1 | 0.9 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 0.1 | 0.9 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.1 | 0.9 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.0 | 0.8 | GO:0042627 | chylomicron(GO:0042627) |
| 0.0 | 0.8 | GO:0097342 | ripoptosome(GO:0097342) |
| 0.0 | 0.8 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.1 | 0.7 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.2 | GO:0004622 | lysophospholipase activity(GO:0004622) |
| 0.2 | 2.0 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 0.1 | 1.4 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.1 | 1.3 | GO:0048185 | activin binding(GO:0048185) |
| 0.1 | 1.2 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.0 | 1.2 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.0 | 1.1 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.0 | 1.1 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 1.0 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.1 | 0.9 | GO:0047144 | 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 1.5 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 1.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.4 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 1.2 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 1.1 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 1.1 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.0 | 1.1 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 1.0 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.0 | 1.0 | PID RAC1 PATHWAY | RAC1 signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.0 | 1.5 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 1.1 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 1.0 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 1.0 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 0.9 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.0 | 0.9 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.9 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.0 | 0.9 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.8 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |