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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for GATA3
Z-value: 2.31
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Transcription factors associated with GATA3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GATA3 | hg19_v2_chr10_+_8096631_8096660 | 0.64 | 3.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_149785236 Show fit | 1.92 |
ENST00000331491.1
|
histone cluster 2, H3d |
|
| chr19_-_55791058 Show fit | 1.68 |
ENST00000587959.1
ENST00000585927.1 ENST00000587922.1 ENST00000585698.1 |
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 |
|
| chr15_-_55488817 Show fit | 1.34 |
ENST00000569386.1
|
ribosomal L24 domain containing 1 |
|
| chr19_-_10227503 Show fit | 1.17 |
ENST00000593054.1
|
eukaryotic translation initiation factor 3, subunit G |
|
| chr7_-_1067968 Show fit | 1.12 |
ENST00000412051.1
|
chromosome 7 open reading frame 50 |
|
| chr6_+_31515337 Show fit | 1.04 |
ENST00000376148.4
ENST00000376145.4 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 |
|
| chr6_+_160693591 Show fit | 1.02 |
ENST00000419196.1
|
RP1-276N6.2 |
|
| chr1_+_56880606 Show fit | 1.01 |
ENST00000451914.1
|
RP4-710M16.2 |
|
| chr6_-_26285737 Show fit | 0.94 |
ENST00000377727.1
ENST00000289352.1 |
histone cluster 1, H4h |
|
| chr6_-_26250835 Show fit | 0.90 |
ENST00000446824.2
|
histone cluster 1, H3f |
Network of associatons between targets according to the STRING database.
First level regulatory network of GATA3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.1 | GO:0032329 | serine transport(GO:0032329) |
| 0.1 | 2.1 | GO:0016024 | CDP-diacylglycerol biosynthetic process(GO:0016024) |
| 0.1 | 1.8 | GO:0031665 | negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665) |
| 0.0 | 1.7 | GO:0097502 | mannosylation(GO:0097502) |
| 0.0 | 1.6 | GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) |
| 0.1 | 1.5 | GO:0090520 | sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520) |
| 0.0 | 1.4 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.0 | 1.4 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.0 | 1.4 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.3 | 1.3 | GO:1902626 | assembly of large subunit precursor of preribosome(GO:1902626) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.4 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 2.5 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 1.9 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 1.8 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.0 | 1.8 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 1.8 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 1.5 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 1.3 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 1.3 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 1.3 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 2.4 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.1 | 1.8 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.1 | 1.6 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.1 | 1.5 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 1.4 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.1 | 1.4 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
| 0.1 | 1.3 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.2 | 1.2 | GO:0046624 | sphingolipid transporter activity(GO:0046624) |
| 0.2 | 1.2 | GO:0017050 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.8 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.0 | 2.7 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.0 | 2.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 2.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 1.8 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 1.6 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 1.6 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.0 | 1.3 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.0 | 1.3 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.3 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 2.6 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 2.4 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 2.4 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 2.0 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 1.8 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.0 | 1.8 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 1.5 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.0 | 1.4 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.0 | 1.3 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |