ISMARA results: GATA2

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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for GATA2

Z-value: 1.30

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Transcription factors associated with GATA2

Gene Symbol	Gene ID	Gene Info
GATA2 Ensembl NCBI GeneCards UniProt	ENSG00000179348.7	GATA binding protein 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GATA2	hg19_v2_chr3_-_128206759_128206781	-0.81	1.9e-01	Click!

Activity profile of GATA2 motif

Sorted Z-values of GATA2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_+_15001430 Show fit	0.72	ENST00000407572.1	MEIG1 Ensembl NCBI GeneCards UniProt Show fit	meiosis/spermiogenesis associated 1
chr13_-_52026730 Show fit	0.68	ENST00000420668.2	INTS6 Ensembl NCBI GeneCards UniProt Show fit	integrator complex subunit 6
chrX_+_100646190 Show fit	0.58	ENST00000471855.1	RPL36A Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein L36a
chr12_-_91546926 Show fit	0.53	ENST00000550758.1	DCN Ensembl NCBI GeneCards UniProt Show fit	decorin
chr12_-_11002063 Show fit	0.51	ENST00000544994.1 ENST00000228811.4 ENST00000540107.1	PRR4 Ensembl NCBI GeneCards UniProt Show fit	proline rich 4 (lacrimal)
chr9_-_34523027 Show fit	0.46	ENST00000399775.2	ENHO Ensembl NCBI GeneCards UniProt Show fit	energy homeostasis associated
chrX_-_108976521 Show fit	0.44	ENST00000469796.2 ENST00000502391.1 ENST00000508092.1 ENST00000340800.2 ENST00000348502.6	ACSL4 Ensembl NCBI GeneCards UniProt Show fit	acyl-CoA synthetase long-chain family member 4
chr17_+_70036164 Show fit	0.41	ENST00000602013.1	AC007461.1 Ensembl NCBI GeneCards UniProt Show fit	Uncharacterized protein
chr4_+_76871883 Show fit	0.41	ENST00000599764.1	AC110615.1 Ensembl NCBI GeneCards UniProt Show fit	Uncharacterized protein
chr10_+_135340859 Show fit	0.40	ENST00000252945.3 ENST00000421586.1 ENST00000418356.1	CYP2E1 Ensembl NCBI GeneCards UniProt Show fit	cytochrome P450, family 2, subfamily E, polypeptide 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0	0.7	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.0	0.7	GO:0070979	protein K11-linked ubiquitination(GO:0070979)
0.1	0.6	GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.1	0.6	GO:0060136	embryonic process involved in female pregnancy(GO:0060136)
0.1	0.6	GO:1903943	regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0	0.6	GO:0075713	establishment of integrated proviral latency(GO:0075713)
0.0	0.6	GO:2000587	negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.0	0.6	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0	0.5	GO:0031119	tRNA pseudouridine synthesis(GO:0031119)

Showing 1 to 10 of 193 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.8	GO:0002102	podosome(GO:0002102)
0.0	0.7	GO:0032039	integrator complex(GO:0032039)
0.0	0.7	GO:0044233	ER-mitochondrion membrane contact site(GO:0044233)
0.0	0.7	GO:0000124	SAGA complex(GO:0000124)
0.1	0.6	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.6	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.6	GO:0097342	ripoptosome(GO:0097342)
0.1	0.5	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.1	0.5	GO:1990578	perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0	0.5	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)

Showing 1 to 10 of 92 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.2	GO:0008395	steroid hydroxylase activity(GO:0008395)
0.1	0.8	GO:0001075	transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.2	0.6	GO:0047676	arachidonate-CoA ligase activity(GO:0047676)
0.0	0.6	GO:0001135	transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0	0.6	GO:0009982	pseudouridine synthase activity(GO:0009982)
0.0	0.6	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1	0.5	GO:0004337	dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.0	0.5	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.5	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.5	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)

Showing 1 to 10 of 110 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
1.2	PID TRAIL PATHWAY	TRAIL signaling pathway
1.1	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.6	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.5	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.4	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.3	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.1	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.1	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway

Showing 1 to 8 of 8 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
1.3	REACTOME FATTY ACYL COA BIOSYNTHESIS	Genes involved in Fatty Acyl-CoA Biosynthesis
0.8	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.7	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.6	REACTOME INTEGRATION OF PROVIRUS	Genes involved in Integration of provirus
0.6	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.6	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.6	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.5	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.5	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.5	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis

Showing 1 to 10 of 22 entries

Results for GATA2

Z-value: 1.30

Motif logo

Transcription factors associated with GATA2

Activity-expression correlation:

Activity profile of GATA2 motif

Sorted Z-values of GATA2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: