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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for GATA1_GATA4
Z-value: 1.30
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Transcription factors associated with GATA1_GATA4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GATA4 | hg19_v2_chr8_+_11534462_11534475 | 0.60 | 4.0e-01 | Click! |
| GATA1 | hg19_v2_chrX_+_48644962_48644983 | -0.35 | 6.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_42630389 Show fit | 1.25 |
ENST00000357001.2
|
guanylate cyclase activator 2A (guanylin) |
|
| chr1_-_226187013 Show fit | 0.83 |
ENST00000272091.7
|
SDE2 telomere maintenance homolog (S. pombe) |
|
| chr1_-_238108575 Show fit | 0.72 |
ENST00000604646.1
|
MT-RNR2-like 11 (pseudogene) |
|
| chr11_-_10920838 Show fit | 0.68 |
ENST00000503469.2
|
CTD-2003C8.2 |
|
| chr10_-_71993176 Show fit | 0.67 |
ENST00000373232.3
|
pyrophosphatase (inorganic) 1 |
|
| chr17_-_79817091 Show fit | 0.66 |
ENST00000570907.1
|
prolyl 4-hydroxylase, beta polypeptide |
|
| chr11_-_61734599 Show fit | 0.62 |
ENST00000532601.1
|
ferritin, heavy polypeptide 1 |
|
| chr6_+_31691121 Show fit | 0.59 |
ENST00000480039.1
ENST00000375810.4 ENST00000375805.2 ENST00000375809.3 ENST00000375804.2 ENST00000375814.3 ENST00000375806.2 |
chromosome 6 open reading frame 25 |
|
| chr19_-_55669093 Show fit | 0.57 |
ENST00000344887.5
|
troponin I type 3 (cardiac) |
|
| chr19_-_39303576 Show fit | 0.56 |
ENST00000594209.1
|
lectin, galactoside-binding, soluble, 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GATA1_GATA4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | GO:0031284 | positive regulation of guanylate cyclase activity(GO:0031284) |
| 0.0 | 1.1 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 0.3 | 1.0 | GO:0071894 | histone H2B conserved C-terminal lysine ubiquitination(GO:0071894) |
| 0.2 | 0.9 | GO:0060437 | lung growth(GO:0060437) |
| 0.2 | 0.8 | GO:0071344 | diphosphate metabolic process(GO:0071344) |
| 0.0 | 0.8 | GO:0006911 | phagocytosis, engulfment(GO:0006911) |
| 0.1 | 0.7 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 0.0 | 0.7 | GO:0034243 | regulation of transcription elongation from RNA polymerase II promoter(GO:0034243) |
| 0.1 | 0.6 | GO:0009822 | alkaloid catabolic process(GO:0009822) |
| 0.1 | 0.6 | GO:0060741 | prostate gland stromal morphogenesis(GO:0060741) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.7 | GO:0016222 | procollagen-proline 4-dioxygenase complex(GO:0016222) |
| 0.2 | 0.6 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
| 0.1 | 0.6 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.1 | 0.5 | GO:0070288 | intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288) |
| 0.0 | 0.5 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 0.5 | GO:0005639 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.0 | 0.4 | GO:0090545 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 0.3 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 0.0 | 0.3 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.0 | 0.3 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.2 | GO:0010853 | cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250) |
| 0.0 | 1.0 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
| 0.0 | 1.0 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.1 | 0.8 | GO:0004427 | inorganic diphosphatase activity(GO:0004427) |
| 0.1 | 0.7 | GO:0019798 | procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798) |
| 0.0 | 0.7 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.1 | 0.6 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.1 | 0.6 | GO:0008865 | glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
| 0.1 | 0.6 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.0 | 0.6 | GO:0003680 | AT DNA binding(GO:0003680) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.1 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 0.9 | REACTOME ACTIVATED POINT MUTANTS OF FGFR2 | Genes involved in Activated point mutants of FGFR2 |
| 0.0 | 0.8 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 0.6 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 0.5 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 0.5 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 0.4 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.0 | 0.4 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 0.3 | REACTOME ENDOGENOUS STEROLS | Genes involved in Endogenous sterols |
| 0.0 | 0.2 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |