ISMARA results: FOXN1

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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for FOXN1

Z-value: 1.06

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Transcription factors associated with FOXN1

Gene Symbol	Gene ID	Gene Info
FOXN1 Ensembl NCBI GeneCards UniProt	ENSG00000109101.3	forkhead box N1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FOXN1	hg19_v2_chr17_+_26833250_26833278	0.92	7.9e-02	Click!

Activity profile of FOXN1 motif

Sorted Z-values of FOXN1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr15_-_71184724 Show fit	0.61	ENST00000560604.1	THAP10 Ensembl NCBI GeneCards UniProt Show fit	THAP domain containing 10
chr3_-_150481218 Show fit	0.52	ENST00000482706.1	SIAH2 Ensembl NCBI GeneCards UniProt Show fit	siah E3 ubiquitin protein ligase 2
chr9_+_114393634 Show fit	0.43	ENST00000556107.1 ENST00000374294.3	DNAJC25 Ensembl NCBI GeneCards UniProt Show fit DNAJC25-GNG10 Ensembl NCBI GeneCards UniProt Show fit	DnaJ (Hsp40) homolog, subfamily C , member 25 DNAJC25-GNG10 readthrough
chr2_+_46769798 Show fit	0.41	ENST00000238738.4	RHOQ Ensembl NCBI GeneCards UniProt Show fit	ras homolog family member Q
chrX_-_83442915 Show fit	0.41	ENST00000262752.2 ENST00000543399.1	RPS6KA6 Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein S6 kinase, 90kDa, polypeptide 6
chr15_+_83776324 Show fit	0.39	ENST00000379390.6 ENST00000379386.4 ENST00000565774.1 ENST00000565982.1	TM6SF1 Ensembl NCBI GeneCards UniProt Show fit	transmembrane 6 superfamily member 1
chr10_+_14880364 Show fit	0.39	ENST00000441647.1	HSPA14 Ensembl NCBI GeneCards UniProt Show fit	heat shock 70kDa protein 14
chr9_+_97136833 Show fit	0.37	ENST00000375344.3	HIATL1 Ensembl NCBI GeneCards UniProt Show fit	hippocampus abundant transcript-like 1
chr2_+_190306159 Show fit	0.36	ENST00000314761.4	WDR75 Ensembl NCBI GeneCards UniProt Show fit	WD repeat domain 75
chr15_+_55700741 Show fit	0.36	ENST00000569691.1	C15orf65 Ensembl NCBI GeneCards UniProt Show fit	chromosome 15 open reading frame 65

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXN1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	GO:0010796	regulation of multivesicular body size(GO:0010796)
0.0	0.7	GO:0070979	protein K11-linked ubiquitination(GO:0070979)
0.1	0.6	GO:0051083	'de novo' cotranslational protein folding(GO:0051083)
0.1	0.6	GO:0001827	inner cell mass cell fate commitment(GO:0001827) inner cell mass cellular morphogenesis(GO:0001828)
0.1	0.6	GO:2001106	regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0	0.6	GO:0090005	negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.1	0.5	GO:0035965	cardiolipin acyl-chain remodeling(GO:0035965)
0.0	0.5	GO:0030916	otic vesicle formation(GO:0030916)
0.0	0.5	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0	0.5	GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)

Showing 1 to 10 of 74 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.8	GO:0030015	CCR4-NOT core complex(GO:0030015)
0.1	0.7	GO:0098837	postsynaptic recycling endosome(GO:0098837)
0.0	0.7	GO:0097228	sperm principal piece(GO:0097228)
0.0	0.5	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.5	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.0	0.5	GO:0036038	MKS complex(GO:0036038)
0.0	0.4	GO:0042382	paraspeckles(GO:0042382)
0.0	0.4	GO:0060077	inhibitory synapse(GO:0060077)
0.0	0.4	GO:0005869	dynactin complex(GO:0005869)
0.0	0.4	GO:0097539	ciliary transition fiber(GO:0097539)

Showing 1 to 10 of 21 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.9	GO:0008408	3'-5' exonuclease activity(GO:0008408)
0.0	0.7	GO:0031489	myosin V binding(GO:0031489)
0.0	0.7	GO:0030331	estrogen receptor binding(GO:0030331)
0.1	0.6	GO:0032427	GBD domain binding(GO:0032427)
0.0	0.6	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0	0.5	GO:0051011	microtubule minus-end binding(GO:0051011)
0.0	0.5	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0	0.5	GO:0000993	RNA polymerase II core binding(GO:0000993)
0.1	0.4	GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.0	0.4	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)

Showing 1 to 10 of 33 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
0.7	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.7	PID BARD1 PATHWAY	BARD1 signaling events
0.6	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.3	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.2	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Showing 1 to 5 of 5 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
0.9	REACTOME KINESINS	Genes involved in Kinesins
0.8	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.8	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.7	REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA	Genes involved in Processing of Capped Intronless Pre-mRNA
0.7	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.6	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.6	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.5	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.5	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.2	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide

Showing 1 to 10 of 10 entries

Results for FOXN1

Z-value: 1.06

Motif logo

Transcription factors associated with FOXN1

Activity-expression correlation:

Activity profile of FOXN1 motif

Sorted Z-values of FOXN1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXN1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: