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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for FOXM1_TBL1XR1
Z-value: 3.20
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Transcription factors associated with FOXM1_TBL1XR1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBL1XR1 | hg19_v2_chr3_-_176914998_176915021 | 0.98 | 1.8e-02 | Click! |
| FOXM1 | hg19_v2_chr12_-_2986107_2986258 | -0.94 | 6.0e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_-_5652705 Show fit | 2.35 |
ENST00000425246.1
|
RP11-336A10.5 |
|
| chr1_+_161035655 Show fit | 2.34 |
ENST00000600454.1
|
Uncharacterized protein |
|
| chr19_+_39759154 Show fit | 1.91 |
ENST00000331982.5
|
interferon, lambda 2 |
|
| chr12_-_79849240 Show fit | 1.89 |
ENST00000550268.1
|
RP1-78O14.1 |
|
| chr19_+_39786962 Show fit | 1.71 |
ENST00000333625.2
|
interferon, lambda 1 |
|
| chr19_-_39735646 Show fit | 1.51 |
ENST00000413851.2
|
interferon, lambda 3 |
|
| chr9_-_21305312 Show fit | 1.49 |
ENST00000259555.4
|
interferon, alpha 5 |
|
| chr2_+_102608306 Show fit | 1.49 |
ENST00000332549.3
|
interleukin 1 receptor, type II |
|
| chr10_+_91061712 Show fit | 1.44 |
ENST00000371826.3
|
interferon-induced protein with tetratricopeptide repeats 2 |
|
| chr5_-_156390230 Show fit | 1.34 |
ENST00000407087.3
ENST00000274532.2 |
T-cell immunoglobulin and mucin domain containing 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXM1_TBL1XR1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.1 | 3.5 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.1 | 3.0 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.1 | 2.7 | GO:0030049 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 0.0 | 2.7 | GO:0051443 | positive regulation of ubiquitin-protein transferase activity(GO:0051443) |
| 0.0 | 2.7 | GO:0010389 | regulation of G2/M transition of mitotic cell cycle(GO:0010389) |
| 0.1 | 2.6 | GO:0071360 | cellular response to exogenous dsRNA(GO:0071360) |
| 0.1 | 2.6 | GO:0000460 | maturation of 5.8S rRNA(GO:0000460) |
| 0.0 | 2.6 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.2 | 2.4 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.9 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 4.3 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 3.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 3.6 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 3.3 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.2 | 3.1 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.2 | 2.9 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 2.9 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.0 | 2.7 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.2 | 2.5 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.9 | GO:0061650 | ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
| 0.1 | 4.3 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.1 | 4.2 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.0 | 3.5 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 3.2 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.0 | 3.2 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 3.1 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.1 | 3.0 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.1 | 3.0 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 0.0 | 3.0 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.8 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 4.7 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 4.4 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 4.1 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.1 | 4.0 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.1 | 2.9 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.1 | 2.7 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 2.6 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 2.6 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 2.5 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.6 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.1 | 5.0 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.1 | 3.7 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 3.6 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.1 | 3.5 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 3.4 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.2 | 3.1 | REACTOME INTEGRATION OF PROVIRUS | Genes involved in Integration of provirus |
| 0.1 | 3.1 | REACTOME DEADENYLATION DEPENDENT MRNA DECAY | Genes involved in Deadenylation-dependent mRNA decay |
| 0.1 | 2.9 | REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A | Genes involved in APC-Cdc20 mediated degradation of Nek2A |
| 0.0 | 2.9 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |