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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for FOXD3_FOXI1_FOXF1
Z-value: 0.98
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Transcription factors associated with FOXD3_FOXI1_FOXF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXF1 | hg19_v2_chr16_+_86544113_86544145 | 0.82 | 1.8e-01 | Click! |
| FOXD3 | hg19_v2_chr1_+_63788730_63788730 | 0.33 | 6.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_+_195413160 Show fit | 0.68 |
ENST00000599448.1
|
long intergenic non-protein coding RNA 969 |
|
| chr11_-_93271058 Show fit | 0.66 |
ENST00000527149.1
|
single-pass membrane protein with coiled-coil domains 4 |
|
| chr5_+_72509751 Show fit | 0.64 |
ENST00000515556.1
ENST00000513379.1 ENST00000427584.2 |
RP11-60A8.1 |
|
| chr7_+_106415457 Show fit | 0.49 |
ENST00000490162.2
ENST00000470135.1 |
RP5-884M6.1 |
|
| chr7_-_75401513 Show fit | 0.47 |
ENST00000005180.4
|
chemokine (C-C motif) ligand 26 |
|
| chr8_+_97597148 Show fit | 0.46 |
ENST00000521590.1
|
syndecan 2 |
|
| chr11_+_8040739 Show fit | 0.43 |
ENST00000534099.1
|
tubby bipartite transcription factor |
|
| chr2_-_208030295 Show fit | 0.42 |
ENST00000458272.1
|
Kruppel-like factor 7 (ubiquitous) |
|
| chr3_-_195310802 Show fit | 0.41 |
ENST00000421243.1
ENST00000453131.1 |
apolipoprotein D |
|
| chr3_+_136649311 Show fit | 0.41 |
ENST00000469404.1
ENST00000467911.1 |
NCK adaptor protein 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXD3_FOXI1_FOXF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | GO:0072619 | interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619) |
| 0.1 | 0.6 | GO:1905150 | regulation of voltage-gated sodium channel activity(GO:1905150) |
| 0.1 | 0.5 | GO:0008218 | bioluminescence(GO:0008218) |
| 0.0 | 0.5 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.0 | 0.5 | GO:0018243 | protein O-linked glycosylation via threonine(GO:0018243) |
| 0.0 | 0.5 | GO:1904778 | regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
| 0.1 | 0.4 | GO:1903676 | regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676) |
| 0.1 | 0.4 | GO:0034443 | negative regulation of lipoprotein oxidation(GO:0034443) |
| 0.1 | 0.4 | GO:0097500 | receptor localization to nonmotile primary cilium(GO:0097500) |
| 0.0 | 0.4 | GO:0048625 | myoblast fate commitment(GO:0048625) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.0 | 0.6 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.0 | 0.6 | GO:0071437 | invadopodium(GO:0071437) |
| 0.0 | 0.5 | GO:0008091 | spectrin(GO:0008091) |
| 0.0 | 0.4 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 0.4 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.0 | 0.4 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 0.4 | GO:0030478 | actin cap(GO:0030478) |
| 0.1 | 0.3 | GO:0005879 | axonemal microtubule(GO:0005879) |
| 0.0 | 0.3 | GO:1990907 | beta-catenin-TCF7L2 complex(GO:0070369) beta-catenin-TCF complex(GO:1990907) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.5 | GO:0031728 | CCR3 chemokine receptor binding(GO:0031728) |
| 0.0 | 0.5 | GO:0042731 | PH domain binding(GO:0042731) |
| 0.0 | 0.5 | GO:0005112 | Notch binding(GO:0005112) |
| 0.1 | 0.4 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
| 0.0 | 0.4 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 0.0 | 0.4 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.1 | 0.3 | GO:0031862 | prostanoid receptor binding(GO:0031862) |
| 0.1 | 0.3 | GO:0052739 | phosphatidylserine 1-acylhydrolase activity(GO:0052739) |
| 0.0 | 0.3 | GO:0004882 | androgen receptor activity(GO:0004882) |
| 0.0 | 0.3 | GO:0071253 | connexin binding(GO:0071253) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 0.0 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 0.4 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 0.3 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 0.2 | REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.0 | 0.2 | REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 0.0 | 0.2 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 0.2 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.0 | 0.1 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 0.1 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.0 | 0.0 | REACTOME G PROTEIN ACTIVATION | Genes involved in G-protein activation |