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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for EZH2
Z-value: 1.43
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Transcription factors associated with EZH2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EZH2 | hg19_v2_chr7_-_148581251_148581347 | -0.82 | 1.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_51152702 Show fit | 2.05 |
ENST00000425202.1
|
chromosome 19 open reading frame 81 |
|
| chr5_+_175298487 Show fit | 2.04 |
ENST00000393745.3
|
complexin 2 |
|
| chr5_+_175298573 Show fit | 1.82 |
ENST00000512824.1
|
complexin 2 |
|
| chr5_+_175298674 Show fit | 1.57 |
ENST00000514150.1
|
complexin 2 |
|
| chr19_-_56056888 Show fit | 0.81 |
ENST00000592464.1
ENST00000420723.3 |
SH3 domain binding kinase family, member 3 |
|
| chr15_+_91416092 Show fit | 0.77 |
ENST00000559353.1
|
furin (paired basic amino acid cleaving enzyme) |
|
| chr10_-_75168071 Show fit | 0.77 |
ENST00000394847.3
|
annexin A7 |
|
| chr9_+_131902283 Show fit | 0.75 |
ENST00000436883.1
ENST00000414510.1 |
protein phosphatase 2A activator, regulatory subunit 4 |
|
| chr11_-_44331679 Show fit | 0.74 |
ENST00000329255.3
|
ALX homeobox 4 |
|
| chrY_+_15418467 Show fit | 0.73 |
ENST00000595988.1
|
Uncharacterized protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of EZH2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.4 | GO:0031915 | positive regulation of synaptic plasticity(GO:0031915) |
| 0.1 | 1.0 | GO:0000821 | regulation of arginine metabolic process(GO:0000821) |
| 0.0 | 0.9 | GO:0046341 | CDP-diacylglycerol metabolic process(GO:0046341) |
| 0.3 | 0.8 | GO:0090472 | viral protein processing(GO:0019082) regulation of nerve growth factor production(GO:0032903) negative regulation of nerve growth factor production(GO:0032904) dibasic protein processing(GO:0090472) |
| 0.0 | 0.8 | GO:0006884 | cell volume homeostasis(GO:0006884) |
| 0.1 | 0.7 | GO:0006477 | protein sulfation(GO:0006477) |
| 0.0 | 0.7 | GO:0046322 | negative regulation of fatty acid oxidation(GO:0046322) |
| 0.0 | 0.7 | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) |
| 0.0 | 0.7 | GO:0035116 | embryonic hindlimb morphogenesis(GO:0035116) |
| 0.1 | 0.6 | GO:0021730 | trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 5.5 | GO:0070033 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554) |
| 0.0 | 0.9 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 0.8 | GO:0031105 | septin complex(GO:0031105) |
| 0.0 | 0.7 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.0 | 0.6 | GO:0042584 | chromaffin granule membrane(GO:0042584) |
| 0.1 | 0.5 | GO:1990393 | 3M complex(GO:1990393) |
| 0.1 | 0.4 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.1 | 0.4 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
| 0.0 | 0.4 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.0 | 0.4 | GO:0070695 | FHF complex(GO:0070695) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.3 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 1.0 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.0 | 0.9 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
| 0.1 | 0.8 | GO:0004466 | long-chain-acyl-CoA dehydrogenase activity(GO:0004466) |
| 0.1 | 0.8 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.0 | 0.8 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.0 | 0.8 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.1 | 0.7 | GO:0050119 | N-acetylglucosamine deacetylase activity(GO:0050119) |
| 0.0 | 0.7 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.0 | 0.7 | GO:0071837 | HMG box domain binding(GO:0071837) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 0.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.6 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 0.4 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.4 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.0 | 0.0 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.0 | 0.7 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.0 | 0.7 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.6 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 0.6 | REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.0 | 0.6 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 0.6 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 0.6 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.5 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.0 | 0.5 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |