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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for ESRRA_ESR2
Z-value: 2.82
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Transcription factors associated with ESRRA_ESR2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ESRRA | hg19_v2_chr11_+_64073022_64073056 | 0.91 | 9.0e-02 | Click! |
| ESR2 | hg19_v2_chr14_-_64804814_64804842 | 0.23 | 7.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ESRRA_ESR2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.9 | GO:0043687 | post-translational protein modification(GO:0043687) |
| 0.0 | 4.3 | GO:0010257 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.1 | 4.0 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 1.2 | 3.5 | GO:0043181 | vacuolar sequestering(GO:0043181) |
| 0.3 | 3.4 | GO:0002159 | desmosome assembly(GO:0002159) |
| 0.2 | 3.3 | GO:0033623 | regulation of integrin activation(GO:0033623) |
| 0.1 | 3.1 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.2 | 3.0 | GO:0038203 | TORC2 signaling(GO:0038203) |
| 0.1 | 3.0 | GO:0046341 | CDP-diacylglycerol metabolic process(GO:0046341) |
| 0.1 | 2.8 | GO:1904659 | hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 64.5 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.1 | 12.1 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 6.5 | GO:0005765 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.1 | 4.9 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.1 | 4.2 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.1 | 4.2 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.1 | 3.6 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.1 | 3.5 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.0 | 3.4 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 2.9 | GO:0045171 | intercellular bridge(GO:0045171) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.4 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.2 | 4.2 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.1 | 3.9 | GO:0003954 | NADH dehydrogenase activity(GO:0003954) |
| 0.0 | 3.6 | GO:0051213 | dioxygenase activity(GO:0051213) |
| 1.2 | 3.5 | GO:0004574 | oligo-1,6-glucosidase activity(GO:0004574) |
| 0.3 | 3.5 | GO:0030976 | thiamine pyrophosphate binding(GO:0030976) |
| 0.3 | 3.1 | GO:0005280 | hydrogen:amino acid symporter activity(GO:0005280) |
| 0.1 | 2.8 | GO:0048185 | activin binding(GO:0048185) |
| 0.0 | 2.8 | GO:0098531 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
| 0.9 | 2.7 | GO:0033867 | Fas-activated serine/threonine kinase activity(GO:0033867) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.1 | 3.5 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 3.3 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 3.1 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 3.0 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 2.5 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 2.3 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.0 | 2.3 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 2.1 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 2.1 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.9 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 6.8 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.1 | 5.4 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 5.3 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 4.7 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 4.4 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 4.1 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 3.7 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 3.3 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 3.1 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |