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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for EN1_ESX1_GBX1

Z-value: 0.66

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Transcription factors associated with EN1_ESX1_GBX1

Gene Symbol Gene ID Gene Info
EN1
ENSG00000163064.6 engrailed homeobox 1
ESX1
ENSG00000123576.5 ESX homeobox 1
GBX1
ENSG00000164900.4 gastrulation brain homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ESX1hg19_v2_chrX_-_103499602_103499617-0.802.0e-01Click!
EN1hg19_v2_chr2_-_119605253_119605264-0.802.0e-01Click!
GBX1hg19_v2_chr7_-_150864635_1508647850.001.0e+00Click!

Activity profile of EN1_ESX1_GBX1 motif

Sorted Z-values of EN1_ESX1_GBX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_99716914 0.81 ENST00000431404.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr9_-_3469181 0.70 ENST00000366116.2
AL365202.1
Uncharacterized protein
chr3_-_167191814 0.47 ENST00000466903.1
ENST00000264677.4
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr12_+_78359999 0.45 ENST00000550503.1
NAV3
neuron navigator 3
chr6_-_26032288 0.42 ENST00000244661.2
HIST1H3B
histone cluster 1, H3b
chr19_+_39421556 0.42 ENST00000407800.2
ENST00000402029.3
MRPS12
mitochondrial ribosomal protein S12
chr7_+_100136811 0.41 ENST00000300176.4
ENST00000262935.4
AGFG2
ArfGAP with FG repeats 2
chr17_+_62223320 0.39 ENST00000580828.1
ENST00000582965.1
SNORA76
small nucleolar RNA, H/ACA box 76
chr4_-_105416039 0.39 ENST00000394767.2
CXXC4
CXXC finger protein 4
chr11_+_35222629 0.38 ENST00000526553.1
CD44
CD44 molecule (Indian blood group)
chr19_+_48949030 0.37 ENST00000253237.5
GRWD1
glutamate-rich WD repeat containing 1
chr17_+_19091325 0.37 ENST00000584923.1
SNORD3A
small nucleolar RNA, C/D box 3A
chrM_+_8366 0.35 ENST00000361851.1
MT-ATP8
mitochondrially encoded ATP synthase 8
chr16_-_29910853 0.35 ENST00000308713.5
SEZ6L2
seizure related 6 homolog (mouse)-like 2
chr11_-_124981475 0.34 ENST00000532156.1
ENST00000532407.1
ENST00000279968.4
ENST00000527766.1
ENST00000529583.1
ENST00000524373.1
ENST00000527271.1
ENST00000526175.1
ENST00000529609.1
ENST00000533273.1
ENST00000531909.1
ENST00000529530.1
TMEM218
transmembrane protein 218
chr14_-_95236551 0.31 ENST00000238558.3
GSC
goosecoid homeobox
chr14_-_37051798 0.30 ENST00000258829.5
NKX2-8
NK2 homeobox 8
chr17_-_40288449 0.30 ENST00000552162.1
ENST00000550504.1
RAB5C
RAB5C, member RAS oncogene family
chr17_-_19015945 0.29 ENST00000573866.2
SNORD3D
small nucleolar RNA, C/D box 3D
chr19_+_48949087 0.27 ENST00000598711.1
GRWD1
glutamate-rich WD repeat containing 1
chr2_-_73460334 0.27 ENST00000258083.2
PRADC1
protease-associated domain containing 1
chr6_-_39693111 0.27 ENST00000373215.3
ENST00000538893.1
ENST00000287152.7
ENST00000373216.3
KIF6
kinesin family member 6
chr6_-_31107127 0.26 ENST00000259845.4
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr6_+_26199737 0.26 ENST00000359985.1
HIST1H2BF
histone cluster 1, H2bf
chr3_-_178103144 0.24 ENST00000417383.1
ENST00000418585.1
ENST00000411727.1
ENST00000439810.1
RP11-33A14.1
RP11-33A14.1
chr14_-_23426231 0.24 ENST00000556915.1
HAUS4
HAUS augmin-like complex, subunit 4
chr6_-_30684898 0.23 ENST00000422266.1
ENST00000416571.1
MDC1
mediator of DNA-damage checkpoint 1
chr6_+_4087664 0.23 ENST00000430835.2
C6orf201
chromosome 6 open reading frame 201
chr6_-_26250835 0.23 ENST00000446824.2
HIST1H3F
histone cluster 1, H3f
chr10_+_35484793 0.22 ENST00000488741.1
ENST00000474931.1
ENST00000468236.1
ENST00000344351.5
ENST00000490511.1
CREM
cAMP responsive element modulator
chr6_+_155538093 0.22 ENST00000462408.2
TIAM2
T-cell lymphoma invasion and metastasis 2
chr19_+_50016411 0.22 ENST00000426395.3
ENST00000600273.1
ENST00000599988.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr20_+_43990576 0.21 ENST00000372727.1
ENST00000414310.1
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr7_+_100860949 0.21 ENST00000305105.2
ZNHIT1
zinc finger, HIT-type containing 1
chr1_-_201140673 0.21 ENST00000367333.2
TMEM9
transmembrane protein 9
chr22_+_38054721 0.21 ENST00000215904.6
PDXP
pyridoxal (pyridoxine, vitamin B6) phosphatase
chr19_-_59084647 0.21 ENST00000594234.1
ENST00000596039.1
MZF1
myeloid zinc finger 1
chr19_+_50016610 0.20 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr14_+_101359265 0.20 ENST00000599197.1
AL117190.3
Esophagus cancer-related gene-2 interaction susceptibility protein; Uncharacterized protein
chr14_+_74034310 0.20 ENST00000538782.1
ACOT2
acyl-CoA thioesterase 2
chr5_+_174151536 0.20 ENST00000239243.6
ENST00000507785.1
MSX2
msh homeobox 2
chr5_+_135394840 0.20 ENST00000503087.1
TGFBI
transforming growth factor, beta-induced, 68kDa
chr5_+_102200948 0.20 ENST00000511477.1
ENST00000506006.1
ENST00000509832.1
PAM
peptidylglycine alpha-amidating monooxygenase
chr11_+_59705928 0.19 ENST00000398992.1
OOSP1
oocyte secreted protein 1
chr6_-_32145861 0.19 ENST00000336984.6
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1
chr8_+_107738343 0.19 ENST00000521592.1
OXR1
oxidation resistance 1
chr19_-_10227503 0.19 ENST00000593054.1
EIF3G
eukaryotic translation initiation factor 3, subunit G
chr16_+_69345243 0.19 ENST00000254950.11
VPS4A
vacuolar protein sorting 4 homolog A (S. cerevisiae)
chr1_+_28261533 0.19 ENST00000411604.1
ENST00000373888.4
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr12_-_89746264 0.19 ENST00000548755.1
DUSP6
dual specificity phosphatase 6
chr12_-_57328187 0.18 ENST00000293502.1
SDR9C7
short chain dehydrogenase/reductase family 9C, member 7
chr14_-_23426322 0.18 ENST00000555367.1
HAUS4
HAUS augmin-like complex, subunit 4
chr12_+_52695617 0.18 ENST00000293525.5
KRT86
keratin 86
chr4_+_144312659 0.17 ENST00000509992.1
GAB1
GRB2-associated binding protein 1
chr6_-_33663474 0.17 ENST00000594414.1
SBP1
SBP1; Uncharacterized protein
chr2_-_99871570 0.17 ENST00000333017.2
ENST00000409679.1
ENST00000423306.1
LYG2
lysozyme G-like 2
chr2_-_224467002 0.17 ENST00000421386.1
ENST00000433889.1
SCG2
secretogranin II
chr14_+_32798547 0.17 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chr10_-_110321541 0.17 ENST00000366253.2
RP11-163F15.1
RP11-163F15.1
chr11_+_115498761 0.17 ENST00000424313.2
AP000997.1
AP000997.1
chr1_-_22215192 0.17 ENST00000374673.3
HSPG2
heparan sulfate proteoglycan 2
chr10_-_128110441 0.16 ENST00000456514.1
LINC00601
long intergenic non-protein coding RNA 601
chr11_-_31531121 0.16 ENST00000532287.1
ENST00000526776.1
ENST00000534812.1
ENST00000529749.1
ENST00000278200.1
ENST00000530023.1
ENST00000533642.1
IMMP1L
IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr9_-_131486367 0.16 ENST00000372663.4
ENST00000406904.2
ENST00000452105.1
ENST00000372672.2
ENST00000372667.5
ZDHHC12
zinc finger, DHHC-type containing 12
chr1_+_160370344 0.16 ENST00000368061.2
VANGL2
VANGL planar cell polarity protein 2
chr2_+_196313239 0.16 ENST00000413290.1
AC064834.1
AC064834.1
chr7_-_72971934 0.16 ENST00000411832.1
BCL7B
B-cell CLL/lymphoma 7B
chr8_-_19614810 0.16 ENST00000524213.1
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr19_-_56110859 0.15 ENST00000221665.3
ENST00000592585.1
FIZ1
FLT3-interacting zinc finger 1
chr5_+_140529630 0.15 ENST00000543635.1
PCDHB6
protocadherin beta 6
chr5_+_53686658 0.15 ENST00000512618.1
LINC01033
long intergenic non-protein coding RNA 1033
chrX_+_47077680 0.15 ENST00000522883.1
CDK16
cyclin-dependent kinase 16
chr19_+_36239576 0.15 ENST00000587751.1
LIN37
lin-37 homolog (C. elegans)
chr16_-_55866997 0.14 ENST00000360526.3
ENST00000361503.4
CES1
carboxylesterase 1
chr17_-_57229155 0.14 ENST00000584089.1
SKA2
spindle and kinetochore associated complex subunit 2
chr3_-_180397256 0.14 ENST00000442201.2
CCDC39
coiled-coil domain containing 39
chr12_-_56694142 0.14 ENST00000550655.1
ENST00000548567.1
ENST00000551430.2
ENST00000351328.3
CS
citrate synthase
chr11_-_64684672 0.13 ENST00000377264.3
ENST00000421419.2
ATG2A
autophagy related 2A
chr4_-_109541539 0.13 ENST00000509984.1
ENST00000507248.1
ENST00000506795.1
RPL34-AS1
RPL34 antisense RNA 1 (head to head)
chr19_-_58951496 0.13 ENST00000254166.3
ZNF132
zinc finger protein 132
chr17_-_64225508 0.13 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr1_-_118472216 0.13 ENST00000369443.5
GDAP2
ganglioside induced differentiation associated protein 2
chr20_+_55967129 0.13 ENST00000371219.2
RBM38
RNA binding motif protein 38
chr13_+_78315295 0.13 ENST00000351546.3
SLAIN1
SLAIN motif family, member 1
chr1_-_68698222 0.13 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
WLS
wntless Wnt ligand secretion mediator
chr18_-_53019208 0.13 ENST00000562607.1
TCF4
transcription factor 4
chr15_+_76629064 0.12 ENST00000290759.4
ISL2
ISL LIM homeobox 2
chr8_+_107738240 0.12 ENST00000449762.2
ENST00000297447.6
OXR1
oxidation resistance 1
chrX_+_107288197 0.12 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr1_+_43291220 0.12 ENST00000372514.3
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chr10_+_94451574 0.12 ENST00000492654.2
HHEX
hematopoietically expressed homeobox
chr17_+_74846230 0.12 ENST00000592919.1
LINC00868
long intergenic non-protein coding RNA 868
chr14_-_36988882 0.12 ENST00000498187.2
NKX2-1
NK2 homeobox 1
chr14_+_74815116 0.12 ENST00000256362.4
VRTN
vertebrae development associated
chrX_-_153602991 0.12 ENST00000369850.3
ENST00000422373.1
FLNA
filamin A, alpha
chr11_-_117747327 0.12 ENST00000584230.1
ENST00000527429.1
ENST00000584394.1
ENST00000532984.1
FXYD6
FXYD6-FXYD2
FXYD domain containing ion transport regulator 6
FXYD6-FXYD2 readthrough
chr4_-_89442940 0.12 ENST00000527353.1
PIGY
phosphatidylinositol glycan anchor biosynthesis, class Y
chr10_+_5005598 0.11 ENST00000442997.1
AKR1C1
aldo-keto reductase family 1, member C1
chr17_+_18086392 0.11 ENST00000541285.1
ALKBH5
alkB, alkylation repair homolog 5 (E. coli)
chr2_-_176046391 0.11 ENST00000392541.3
ENST00000409194.1
ATP5G3
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
chr5_-_56778635 0.11 ENST00000423391.1
ACTBL2
actin, beta-like 2
chr19_-_14992264 0.11 ENST00000327462.2
OR7A17
olfactory receptor, family 7, subfamily A, member 17
chr11_-_62313090 0.11 ENST00000528508.1
ENST00000533365.1
AHNAK
AHNAK nucleoprotein
chr1_-_36915880 0.11 ENST00000445843.3
OSCP1
organic solute carrier partner 1
chr7_-_100860851 0.11 ENST00000223127.3
PLOD3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr16_-_31085514 0.11 ENST00000300849.4
ZNF668
zinc finger protein 668
chr7_-_137028534 0.11 ENST00000348225.2
PTN
pleiotrophin
chr5_+_137673200 0.11 ENST00000434981.2
FAM53C
family with sequence similarity 53, member C
chr22_-_32767017 0.11 ENST00000400234.1
RFPL3S
RFPL3 antisense
chr16_-_2264779 0.10 ENST00000333503.7
PGP
phosphoglycolate phosphatase
chr5_+_172068232 0.10 ENST00000520919.1
ENST00000522853.1
ENST00000369800.5
NEURL1B
neuralized E3 ubiquitin protein ligase 1B
chr3_-_178984759 0.10 ENST00000349697.2
ENST00000497599.1
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chrX_+_107288239 0.10 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr11_+_57435441 0.10 ENST00000528177.1
ZDHHC5
zinc finger, DHHC-type containing 5
chr9_+_34652164 0.10 ENST00000441545.2
ENST00000553620.1
IL11RA
interleukin 11 receptor, alpha
chr17_+_42634844 0.10 ENST00000315323.3
FZD2
frizzled family receptor 2
chr2_+_217524323 0.10 ENST00000456764.1
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr19_+_4007644 0.10 ENST00000262971.2
PIAS4
protein inhibitor of activated STAT, 4
chr5_+_142286887 0.10 ENST00000451259.1
ARHGAP26
Rho GTPase activating protein 26
chr17_-_7307358 0.10 ENST00000576017.1
ENST00000302422.3
ENST00000535512.1
TMEM256
TMEM256-PLSCR3
transmembrane protein 256
TMEM256-PLSCR3 readthrough (NMD candidate)
chr5_+_52776449 0.10 ENST00000396947.3
FST
follistatin
chr12_+_53662110 0.10 ENST00000552462.1
ESPL1
extra spindle pole bodies homolog 1 (S. cerevisiae)
chr19_-_3557570 0.10 ENST00000355415.2
MFSD12
major facilitator superfamily domain containing 12
chr4_+_77356248 0.10 ENST00000296043.6
SHROOM3
shroom family member 3
chr22_-_33968239 0.10 ENST00000452586.2
ENST00000421768.1
LARGE
like-glycosyltransferase
chr5_+_52776228 0.10 ENST00000256759.3
FST
follistatin
chr6_+_26020672 0.10 ENST00000357647.3
HIST1H3A
histone cluster 1, H3a
chr22_-_42765174 0.10 ENST00000432473.1
ENST00000412060.1
ENST00000424852.1
Z83851.1
Z83851.1
chr5_+_125758813 0.09 ENST00000285689.3
ENST00000515200.1
GRAMD3
GRAM domain containing 3
chr14_-_23426337 0.09 ENST00000342454.8
ENST00000555986.1
ENST00000541587.1
ENST00000554516.1
ENST00000347758.2
ENST00000206474.7
ENST00000555040.1
HAUS4
HAUS augmin-like complex, subunit 4
chr7_-_137028498 0.09 ENST00000393083.2
PTN
pleiotrophin
chr6_+_26365443 0.09 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
BTN3A2
butyrophilin, subfamily 3, member A2
chr17_+_42264556 0.09 ENST00000319511.6
ENST00000589785.1
ENST00000592825.1
ENST00000589184.1
TMUB2
transmembrane and ubiquitin-like domain containing 2
chr19_-_46088068 0.09 ENST00000263275.4
ENST00000323060.3
OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr17_+_42148097 0.09 ENST00000269097.4
G6PC3
glucose 6 phosphatase, catalytic, 3
chr19_-_6737576 0.09 ENST00000601716.1
ENST00000264080.7
GPR108
G protein-coupled receptor 108
chr1_-_21625486 0.09 ENST00000481130.2
ECE1
endothelin converting enzyme 1
chr4_+_71019903 0.09 ENST00000344526.5
C4orf40
chromosome 4 open reading frame 40
chr6_-_116833500 0.09 ENST00000356128.4
TRAPPC3L
trafficking protein particle complex 3-like
chr22_-_32766972 0.09 ENST00000382084.4
ENST00000382086.2
RFPL3S
RFPL3 antisense
chr19_-_6737241 0.09 ENST00000430424.4
ENST00000597298.1
GPR108
G protein-coupled receptor 108
chr7_-_99716952 0.09 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr11_-_36310958 0.09 ENST00000532705.1
ENST00000263401.5
ENST00000452374.2
COMMD9
COMM domain containing 9
chr2_+_65216462 0.09 ENST00000234256.3
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr16_+_68279207 0.09 ENST00000413021.2
ENST00000565744.1
ENST00000219345.5
PLA2G15
phospholipase A2, group XV
chrX_+_591524 0.09 ENST00000554971.1
ENST00000381575.1
SHOX
short stature homeobox
chr4_+_40198527 0.09 ENST00000381799.5
RHOH
ras homolog family member H
chr16_+_50300427 0.09 ENST00000394697.2
ENST00000566433.2
ENST00000538642.1
ADCY7
adenylate cyclase 7
chr17_+_79650962 0.09 ENST00000329138.4
HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr2_-_224467093 0.09 ENST00000305409.2
SCG2
secretogranin II
chr11_+_128563652 0.09 ENST00000527786.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr5_+_125758865 0.09 ENST00000542322.1
ENST00000544396.1
GRAMD3
GRAM domain containing 3
chr5_+_133562095 0.09 ENST00000602919.1
CTD-2410N18.3
CTD-2410N18.3
chr1_+_54569968 0.09 ENST00000391366.1
AL161915.1
Uncharacterized protein
chr19_+_34287751 0.09 ENST00000590771.1
ENST00000589786.1
ENST00000284006.6
ENST00000588881.1
KCTD15
potassium channel tetramerization domain containing 15
chr2_-_200335983 0.08 ENST00000457245.1
SATB2
SATB homeobox 2
chr16_+_68279256 0.08 ENST00000564827.2
ENST00000566188.1
ENST00000444212.2
ENST00000568082.1
PLA2G15
phospholipase A2, group XV
chr12_+_26348246 0.08 ENST00000422622.2
SSPN
sarcospan
chr12_-_121972556 0.08 ENST00000545022.1
KDM2B
lysine (K)-specific demethylase 2B
chr14_+_62037287 0.08 ENST00000556569.1
RP11-47I22.3
Uncharacterized protein
chr12_+_53662073 0.08 ENST00000553219.1
ENST00000257934.4
ESPL1
extra spindle pole bodies homolog 1 (S. cerevisiae)
chr3_-_98235962 0.08 ENST00000513873.1
CLDND1
claudin domain containing 1
chr17_+_43238438 0.08 ENST00000593138.1
ENST00000586681.1
HEXIM2
hexamethylene bis-acetamide inducible 2
chr11_+_112041253 0.08 ENST00000532612.1
AP002884.3
AP002884.3
chr3_+_152552685 0.08 ENST00000305097.3
P2RY1
purinergic receptor P2Y, G-protein coupled, 1
chr11_+_818902 0.08 ENST00000336615.4
PNPLA2
patatin-like phospholipase domain containing 2
chr19_-_14064114 0.08 ENST00000585607.1
ENST00000538517.2
ENST00000587458.1
ENST00000538371.2
PODNL1
podocan-like 1
chr19_-_49314269 0.08 ENST00000545387.2
ENST00000316273.6
ENST00000402551.1
ENST00000598162.1
ENST00000599246.1
BCAT2
branched chain amino-acid transaminase 2, mitochondrial
chr17_-_8093471 0.08 ENST00000389017.4
C17orf59
chromosome 17 open reading frame 59
chr15_-_55562582 0.08 ENST00000396307.2
RAB27A
RAB27A, member RAS oncogene family
chr2_+_211342400 0.08 ENST00000417946.1
ENST00000518043.1
ENST00000523702.1
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr2_-_98280383 0.08 ENST00000289228.5
ACTR1B
ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
chr1_+_186265399 0.08 ENST00000367486.3
ENST00000367484.3
ENST00000533951.1
ENST00000367482.4
ENST00000367483.4
ENST00000367485.4
ENST00000445192.2
PRG4
proteoglycan 4
chr12_+_70219052 0.08 ENST00000552032.2
ENST00000547771.2
MYRFL
myelin regulatory factor-like
chr11_-_26593649 0.08 ENST00000455601.2
MUC15
mucin 15, cell surface associated
chrM_-_14670 0.08 ENST00000361681.2
MT-ND6
mitochondrially encoded NADH dehydrogenase 6
chr19_-_2944907 0.08 ENST00000314531.4
ZNF77
zinc finger protein 77
chr19_+_4153598 0.08 ENST00000078445.2
ENST00000252587.3
ENST00000595923.1
ENST00000602257.1
ENST00000602147.1
CREB3L3
cAMP responsive element binding protein 3-like 3
chr16_+_3184924 0.08 ENST00000574902.1
ENST00000396878.3
ZNF213
zinc finger protein 213
chr11_-_129062093 0.07 ENST00000310343.9
ARHGAP32
Rho GTPase activating protein 32
chr1_-_68698197 0.07 ENST00000370973.2
ENST00000370971.1
WLS
wntless Wnt ligand secretion mediator
chr2_+_45168875 0.07 ENST00000260653.3
SIX3
SIX homeobox 3
chrX_-_110655306 0.07 ENST00000371993.2
DCX
doublecortin
chr12_+_113587558 0.07 ENST00000335621.6
CCDC42B
coiled-coil domain containing 42B
chr11_+_57435219 0.07 ENST00000527985.1
ENST00000287169.3
ZDHHC5
zinc finger, DHHC-type containing 5
chr15_-_64673665 0.07 ENST00000300035.4
KIAA0101
KIAA0101
chr11_+_77532155 0.07 ENST00000532481.1
ENST00000526415.1
ENST00000393427.2
ENST00000527134.1
ENST00000304716.8
AAMDC
adipogenesis associated, Mth938 domain containing
chr17_+_47448102 0.07 ENST00000576461.1
RP11-81K2.1
Uncharacterized protein
chr12_+_56473910 0.07 ENST00000411731.2
ERBB3
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
chrX_-_64196307 0.07 ENST00000545618.1
ZC4H2
zinc finger, C4H2 domain containing
chr9_+_139780942 0.07 ENST00000247668.2
ENST00000359662.3
TRAF2
TNF receptor-associated factor 2
chr14_-_23504337 0.07 ENST00000361611.6
PSMB5
proteasome (prosome, macropain) subunit, beta type, 5
chr17_-_4458616 0.07 ENST00000381556.2
MYBBP1A
MYB binding protein (P160) 1a
chr14_+_56584414 0.07 ENST00000559044.1
PELI2
pellino E3 ubiquitin protein ligase family member 2
chr15_-_72565340 0.07 ENST00000568360.1
PARP6
poly (ADP-ribose) polymerase family, member 6
chr15_-_64673630 0.07 ENST00000558008.1
ENST00000559519.1
ENST00000380258.2
KIAA0101
KIAA0101
chr2_-_208031943 0.07 ENST00000421199.1
ENST00000457962.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr7_+_116660246 0.07 ENST00000434836.1
ENST00000393443.1
ENST00000465133.1
ENST00000477742.1
ENST00000393447.4
ENST00000393444.3
ST7
suppression of tumorigenicity 7
chr17_-_73901494 0.07 ENST00000309352.3
MRPL38
mitochondrial ribosomal protein L38
chr11_+_3819049 0.07 ENST00000396986.2
ENST00000300730.6
ENST00000532535.1
ENST00000396993.4
ENST00000396991.2
ENST00000532523.1
ENST00000459679.1
ENST00000464261.1
ENST00000464906.2
ENST00000464441.1
PGAP2
post-GPI attachment to proteins 2

Network of associatons between targets according to the STRING database.

First level regulatory network of EN1_ESX1_GBX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.1 0.2 GO:0031247 actin rod assembly(GO:0031247)
0.1 0.2 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.1 0.2 GO:0051795 positive regulation of catagen(GO:0051795) activation of meiosis(GO:0090427)
0.1 0.2 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.1 0.4 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.1 0.2 GO:0060488 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1 0.2 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.0 0.2 GO:0046338 phosphatidylethanolamine catabolic process(GO:0046338)
0.0 0.4 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 0.1 GO:0021524 visceral motor neuron differentiation(GO:0021524)
0.0 0.1 GO:0010621 negative regulation of transcription by transcription factor localization(GO:0010621) gall bladder development(GO:0061010)
0.0 0.1 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.0 0.2 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.0 0.1 GO:0090119 vesicle-mediated cholesterol transport(GO:0090119)
0.0 0.2 GO:0018032 peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179)
0.0 0.1 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.0 0.1 GO:0046946 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.0 0.1 GO:2001190 MHC class II protein complex assembly(GO:0002399) peptide antigen assembly with MHC class II protein complex(GO:0002503) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.0 0.1 GO:0006114 glycerol biosynthetic process(GO:0006114)
0.0 0.1 GO:1903717 carbamoyl phosphate metabolic process(GO:0070408) carbamoyl phosphate biosynthetic process(GO:0070409) response to ammonia(GO:1903717) cellular response to ammonia(GO:1903718)
0.0 0.1 GO:0014016 neuroblast differentiation(GO:0014016) forebrain dorsal/ventral pattern formation(GO:0021798)
0.0 0.2 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.2 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.3 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.0 0.1 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.1 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.0 0.1 GO:0035553 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.2 GO:0071395 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.0 0.1 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.0 0.1 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
0.0 0.7 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.1 GO:0006550 isoleucine catabolic process(GO:0006550)
0.0 0.1 GO:1902081 regulation of calcium ion import into sarcoplasmic reticulum(GO:1902080) negative regulation of calcium ion import into sarcoplasmic reticulum(GO:1902081)
0.0 0.1 GO:0021759 globus pallidus development(GO:0021759)
0.0 0.1 GO:1902725 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723) negative regulation of satellite cell differentiation(GO:1902725)
0.0 0.3 GO:0014029 neural crest formation(GO:0014029)
0.0 0.2 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.0 0.1 GO:1900111 positive regulation of histone H3-K9 dimethylation(GO:1900111)
0.0 0.3 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 0.2 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.0 0.2 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.0 GO:0021776 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.0 0.1 GO:1903719 regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721)
0.0 0.2 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.1 GO:0000294 nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay(GO:0000294)
0.0 0.1 GO:0002767 immune response-inhibiting cell surface receptor signaling pathway(GO:0002767)
0.0 0.1 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0 0.4 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.1 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.0 0.1 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.0 0.2 GO:0003150 muscular septum morphogenesis(GO:0003150)
0.0 0.0 GO:0061727 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 0.1 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.0 0.1 GO:0034959 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.0 0.0 GO:0071139 resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140)
0.0 0.1 GO:1902231 positive regulation of keratinocyte apoptotic process(GO:1902174) positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 0.1 GO:0060922 cardiac septum cell differentiation(GO:0003292) atrioventricular node cell differentiation(GO:0060922) atrioventricular node cell development(GO:0060928)
0.0 0.1 GO:0021993 initiation of neural tube closure(GO:0021993)
0.0 0.0 GO:0061743 motor learning(GO:0061743)
0.0 0.1 GO:1990418 response to insulin-like growth factor stimulus(GO:1990418)
0.0 0.1 GO:1905040 vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.0 0.1 GO:0090410 malonate catabolic process(GO:0090410)
0.0 0.4 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.1 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.0 0.0 GO:0033025 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
0.0 0.1 GO:0006868 glutamine transport(GO:0006868) L-cystine transport(GO:0015811)
0.0 0.0 GO:0019859 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0 0.1 GO:0045229 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.0 0.1 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.1 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
0.0 0.2 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.1 GO:0093001 glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001)
0.0 0.1 GO:0008063 Toll signaling pathway(GO:0008063)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.4 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 0.6 GO:0070652 HAUS complex(GO:0070652)
0.0 0.2 GO:0060187 cell pole(GO:0060187)
0.0 0.9 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.1 GO:0031523 Myb complex(GO:0031523)
0.0 0.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.1 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.0 0.2 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.3 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.1 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
0.0 0.1 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.0 0.1 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.0 0.0 GO:0043614 multi-eIF complex(GO:0043614) translation preinitiation complex(GO:0070993)
0.0 0.3 GO:0031045 dense core granule(GO:0031045)
0.0 0.1 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.4 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.1 GO:0000835 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 0.5 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.1 GO:0036338 viral envelope(GO:0019031) viral membrane(GO:0036338)
0.0 0.2 GO:0090543 ESCRT III complex(GO:0000815) Flemming body(GO:0090543)
0.0 0.1 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.2 GO:0000812 Swr1 complex(GO:0000812)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.2 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.1 0.3 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.1 0.9 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 0.2 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.0 0.1 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.0 0.1 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.0 0.2 GO:0004598 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.0 0.1 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.1 GO:0000994 RNA polymerase III core binding(GO:0000994)
0.0 0.1 GO:0005174 CD40 receptor binding(GO:0005174)
0.0 0.1 GO:0004803 transposase activity(GO:0004803)
0.0 0.1 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.0 0.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0033823 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823) procollagen galactosyltransferase activity(GO:0050211)
0.0 0.2 GO:0047086 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086)
0.0 0.1 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.2 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.0 0.2 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.1 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.0 0.1 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 0.1 GO:0016250 N-sulfoglucosamine sulfohydrolase activity(GO:0016250) hydrolase activity, acting on acid sulfur-nitrogen bonds(GO:0016826)
0.0 0.1 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.0 0.1 GO:0004088 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.0 0.2 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 0.0 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 0.2 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.1 GO:0004084 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.1 GO:0090409 malonyl-CoA synthetase activity(GO:0090409)
0.0 0.0 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.0 0.1 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.0 0.0 GO:0035248 alpha-1,4-N-acetylgalactosaminyltransferase activity(GO:0035248)
0.0 0.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.2 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.1 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.1 GO:0015186 L-cystine transmembrane transporter activity(GO:0015184) L-glutamine transmembrane transporter activity(GO:0015186)
0.0 0.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.1 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.0 0.4 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.3 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.8 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening