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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for ELK4_ETV5_ELK1_ELK3_ELF4
Z-value: 1.91
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Transcription factors associated with ELK4_ETV5_ELK1_ELK3_ELF4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000158711.9 | ETS transcription factor ELK4 | |
| ENSG00000244405.3 | ETS variant transcription factor 5 | |
| ENSG00000126767.13 | ETS transcription factor ELK1 | |
| ENSG00000111145.3 | ETS transcription factor ELK3 | |
| ENSG00000102034.12 | E74 like ETS transcription factor 4 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ELK1 | hg19_v2_chrX_-_47509887_47509990 | -0.99 | 1.0e-02 | Click! |
| ELF4 | hg19_v2_chrX_-_129244336_129244442 | 0.98 | 1.7e-02 | Click! |
| ELK3 | hg19_v2_chr12_+_96588143_96588185 | -0.90 | 9.8e-02 | Click! |
| ELK4 | hg19_v2_chr1_-_205601064_205601090 | 0.87 | 1.3e-01 | Click! |
| ETV5 | hg19_v2_chr3_-_185826286_185826464 | -0.44 | 5.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_47324008 Show fit | 2.74 |
ENST00000425853.1
|
kinesin family member 9 |
|
| chr15_-_71184724 Show fit | 2.45 |
ENST00000560604.1
|
THAP domain containing 10 |
|
| chr12_-_110888103 Show fit | 2.40 |
ENST00000426440.1
ENST00000228825.7 |
actin related protein 2/3 complex, subunit 3, 21kDa |
|
| chr3_-_47324242 Show fit | 2.23 |
ENST00000456548.1
ENST00000432493.1 ENST00000335044.2 ENST00000444589.2 |
kinesin family member 9 |
|
| chr3_-_47324079 Show fit | 1.82 |
ENST00000352910.4
|
kinesin family member 9 |
|
| chr19_+_17326521 Show fit | 1.79 |
ENST00000593597.1
|
unconventional SNARE in the ER 1 homolog (S. cerevisiae) |
|
| chr18_+_33552667 Show fit | 1.73 |
ENST00000333234.5
|
chromosome 18 open reading frame 21 |
|
| chr10_+_15001430 Show fit | 1.67 |
ENST00000407572.1
|
meiosis/spermiogenesis associated 1 |
|
| chr15_+_74833518 Show fit | 1.60 |
ENST00000346246.5
|
AT rich interactive domain 3B (BRIGHT-like) |
|
| chr3_-_28390120 Show fit | 1.59 |
ENST00000334100.6
|
5-azacytidine induced 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ELK4_ETV5_ELK1_ELK3_ELF4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.8 | GO:0045047 | protein targeting to ER(GO:0045047) |
| 0.2 | 7.8 | GO:0071801 | regulation of podosome assembly(GO:0071801) |
| 0.1 | 5.4 | GO:0006363 | termination of RNA polymerase I transcription(GO:0006363) |
| 0.6 | 4.9 | GO:0044565 | dendritic cell proliferation(GO:0044565) |
| 0.1 | 3.9 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.1 | 3.6 | GO:0042407 | cristae formation(GO:0042407) |
| 0.8 | 3.4 | GO:0001732 | formation of cytoplasmic translation initiation complex(GO:0001732) |
| 0.4 | 3.4 | GO:2000825 | positive regulation of androgen receptor activity(GO:2000825) |
| 0.0 | 3.2 | GO:0048208 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 0.2 | 2.9 | GO:0075713 | establishment of integrated proviral latency(GO:0075713) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.9 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 7.8 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 6.0 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.5 | 5.8 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 0.0 | 4.4 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.1 | 4.2 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 3.3 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.0 | 3.3 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.0 | 2.9 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 2.8 | GO:0005838 | proteasome regulatory particle(GO:0005838) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.7 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 9.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 6.2 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.1 | 5.0 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 4.5 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 3.9 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.2 | 3.7 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 0.0 | 3.7 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.8 | 3.3 | GO:0098808 | mRNA cap binding(GO:0098808) |
| 0.1 | 3.3 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.2 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.2 | 4.8 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 4.3 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 4.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 3.5 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.0 | 3.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 3.1 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 2.6 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 2.4 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 2.2 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.0 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 9.4 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 9.1 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 6.7 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.1 | 6.6 | REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 | Genes involved in SCF-beta-TrCP mediated degradation of Emi1 |
| 0.1 | 4.6 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.2 | 4.4 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.1 | 4.3 | REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A | Genes involved in APC-Cdc20 mediated degradation of Nek2A |
| 0.0 | 4.0 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.2 | 3.6 | REACTOME INTEGRATION OF PROVIRUS | Genes involved in Integration of provirus |