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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for EGR3_EGR2
Z-value: 0.78
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Transcription factors associated with EGR3_EGR2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EGR2 | hg19_v2_chr10_-_64576105_64576133 | -0.96 | 4.2e-02 | Click! |
| EGR3 | hg19_v2_chr8_-_22550815_22550844 | -0.77 | 2.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_76649753 Show fit | 0.77 |
ENST00000603759.1
|
USO1 vesicle transport factor |
|
| chr6_+_12012170 Show fit | 0.51 |
ENST00000487103.1
|
human immunodeficiency virus type I enhancer binding protein 1 |
|
| chr19_-_49622348 Show fit | 0.44 |
ENST00000408991.2
|
chromosome 19 open reading frame 73 |
|
| chr2_-_98612379 Show fit | 0.43 |
ENST00000425805.2
|
transmembrane protein 131 |
|
| chr2_+_149402009 Show fit | 0.37 |
ENST00000457184.1
|
enhancer of polycomb homolog 2 (Drosophila) |
|
| chr19_+_46144884 Show fit | 0.35 |
ENST00000593161.1
|
chromosome 19 open reading frame 83 |
|
| chr1_-_85156417 Show fit | 0.34 |
ENST00000422026.1
|
synovial sarcoma, X breakpoint 2 interacting protein |
|
| chr11_+_64009072 Show fit | 0.32 |
ENST00000535135.1
ENST00000394540.3 |
FK506 binding protein 2, 13kDa |
|
| chr4_-_83295296 Show fit | 0.32 |
ENST00000507010.1
ENST00000503822.1 |
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) |
|
| chr16_-_31021717 Show fit | 0.32 |
ENST00000565419.1
|
syntaxin 1B |
Network of associatons between targets according to the STRING database.
First level regulatory network of EGR3_EGR2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.8 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.2 | 0.5 | GO:1904586 | response to putrescine(GO:1904585) cellular response to putrescine(GO:1904586) hepatocyte dedifferentiation(GO:1990828) |
| 0.0 | 0.4 | GO:0034063 | stress granule assembly(GO:0034063) |
| 0.1 | 0.3 | GO:1903422 | negative regulation of synaptic vesicle recycling(GO:1903422) |
| 0.0 | 0.3 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.0 | 0.3 | GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus(GO:1990416) |
| 0.0 | 0.3 | GO:0010968 | regulation of microtubule nucleation(GO:0010968) |
| 0.0 | 0.3 | GO:1903830 | magnesium ion transmembrane transport(GO:1903830) |
| 0.0 | 0.3 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 0.0 | 0.3 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | GO:0016461 | unconventional myosin complex(GO:0016461) |
| 0.0 | 0.4 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.1 | 0.3 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.0 | 0.3 | GO:0097539 | ciliary transition fiber(GO:0097539) |
| 0.0 | 0.2 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.0 | 0.2 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.0 | 0.2 | GO:0032039 | integrator complex(GO:0032039) |
| 0.0 | 0.2 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 0.1 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) beta-catenin-TCF complex(GO:1990907) |
| 0.0 | 0.1 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
| 0.0 | 0.5 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.0 | 0.5 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.0 | 0.4 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.0 | 0.4 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.0 | 0.3 | GO:0047894 | flavonol 3-sulfotransferase activity(GO:0047894) |
| 0.0 | 0.3 | GO:0070181 | small ribosomal subunit rRNA binding(GO:0070181) |
| 0.0 | 0.3 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 0.2 | GO:0004883 | glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051) |
| 0.0 | 0.2 | GO:0035500 | MH2 domain binding(GO:0035500) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 0.2 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 0.0 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.0 | 0.1 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |