ISMARA results: EBF3

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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for EBF3

Z-value: 1.72

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Transcription factors associated with EBF3

Gene Symbol	Gene ID	Gene Info
EBF3 Ensembl NCBI GeneCards UniProt	ENSG00000108001.9	EBF transcription factor 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
EBF3	hg19_v2_chr10_-_131640435_131640435	0.70	3.0e-01	Click!

Activity profile of EBF3 motif

Sorted Z-values of EBF3 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_-_9482010 Show fit	1.41	ENST00000596206.1	AC132192.1 Ensembl NCBI GeneCards UniProt Show fit	LOC644656 protein; Uncharacterized protein
chr3_-_129375556 Show fit	1.37	ENST00000510323.1	TMCC1 Ensembl NCBI GeneCards UniProt Show fit	transmembrane and coiled-coil domain family 1
chr16_+_3068393 Show fit	1.36	ENST00000573001.1	TNFRSF12A Ensembl NCBI GeneCards UniProt Show fit	tumor necrosis factor receptor superfamily, member 12A
chr11_+_22646739 Show fit	1.18	ENST00000428556.2	AC103801.2 Ensembl NCBI GeneCards UniProt Show fit	AC103801.2
chr11_-_67120974 Show fit	1.11	ENST00000539074.1 ENST00000312419.3	POLD4 Ensembl NCBI GeneCards UniProt Show fit	polymerase (DNA-directed), delta 4, accessory subunit
chr19_+_55996565 Show fit	1.07	ENST00000587400.1	NAT14 Ensembl NCBI GeneCards UniProt Show fit	N-acetyltransferase 14 (GCN5-related, putative)
chr14_-_23791484 Show fit	1.05	ENST00000594872.1	AL049829.1 Ensembl NCBI GeneCards UniProt Show fit	Uncharacterized protein
chr19_+_39904168 Show fit	1.05	ENST00000438123.1 ENST00000409797.2 ENST00000451354.2	PLEKHG2 Ensembl NCBI GeneCards UniProt Show fit	pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr7_-_100881041 Show fit	1.03	ENST00000412417.1 ENST00000414035.1	CLDN15 Ensembl NCBI GeneCards UniProt Show fit	claudin 15
chr17_+_73606766 Show fit	0.90	ENST00000578462.1	MYO15B Ensembl NCBI GeneCards UniProt Show fit	myosin XVB pseudogene

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of EBF3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.7	GO:1990573	potassium ion import across plasma membrane(GO:1990573)
0.1	1.7	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1	1.4	GO:0006931	substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0	1.4	GO:0007029	endoplasmic reticulum organization(GO:0007029)
0.3	1.3	GO:0032218	riboflavin transport(GO:0032218)
0.2	1.3	GO:2000857	positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.2	1.1	GO:0030037	actin filament reorganization involved in cell cycle(GO:0030037)
0.0	1.1	GO:0032201	telomere maintenance via semi-conservative replication(GO:0032201)
0.2	1.0	GO:0038018	Wnt receptor catabolic process(GO:0038018)
0.1	1.0	GO:0005984	disaccharide metabolic process(GO:0005984)

Showing 1 to 10 of 121 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.8	GO:0005581	collagen trimer(GO:0005581)
0.1	1.7	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0	1.6	GO:0016328	lateral plasma membrane(GO:0016328)
0.0	1.3	GO:0005779	integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.2	1.1	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.0	1.0	GO:0016459	myosin complex(GO:0016459)
0.0	0.9	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.0	0.9	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.0	0.8	GO:0000813	ESCRT I complex(GO:0000813)
0.0	0.7	GO:0033093	Weibel-Palade body(GO:0033093)

Showing 1 to 10 of 38 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.7	GO:0005518	collagen binding(GO:0005518)
0.1	1.7	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0	1.6	GO:0008080	N-acetyltransferase activity(GO:0008080)
0.3	1.3	GO:0032217	riboflavin transporter activity(GO:0032217)
0.1	1.1	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	1.1	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)
0.0	1.0	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.2	0.9	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.0	0.9	GO:0005109	frizzled binding(GO:0005109)
0.1	0.8	GO:0019887	protein kinase regulator activity(GO:0019887)

Showing 1 to 10 of 80 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
1.2	PID AP1 PATHWAY	AP-1 transcription factor network
1.1	PID BMP PATHWAY	BMP receptor signaling
1.1	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.9	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.5	PID ARF 3PATHWAY	Arf1 pathway
0.5	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.5	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.4	PID IL27 PATHWAY	IL27-mediated signaling events
0.3	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.3	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway

Showing 1 to 10 of 10 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.7	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.0	1.5	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.0	1.4	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.1	1.1	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
0.0	1.1	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	0.9	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.1	0.8	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.7	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.0	0.7	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	0.6	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis

Showing 1 to 10 of 24 entries

Results for EBF3

Z-value: 1.72

Motif logo

Transcription factors associated with EBF3

Activity-expression correlation:

Activity profile of EBF3 motif

Sorted Z-values of EBF3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of EBF3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: