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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for EBF1
Z-value: 2.47
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Transcription factors associated with EBF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EBF1 | hg19_v2_chr5_-_158526756_158526797 | 0.70 | 3.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_100881109 Show fit | 2.14 |
ENST00000308344.5
|
claudin 15 |
|
| chr7_-_100881041 Show fit | 1.64 |
ENST00000412417.1
ENST00000414035.1 |
claudin 15 |
|
| chr15_-_74494779 Show fit | 1.49 |
ENST00000571341.1
|
stimulated by retinoic acid 6 |
|
| chr1_+_874649 Show fit | 1.43 |
ENST00000455979.1
|
sterile alpha motif domain containing 11 |
|
| chr3_-_129375556 Show fit | 1.39 |
ENST00000510323.1
|
transmembrane and coiled-coil domain family 1 |
|
| chr11_-_57089774 Show fit | 1.33 |
ENST00000527207.1
|
tankyrase 1 binding protein 1, 182kDa |
|
| chr19_+_41107249 Show fit | 1.27 |
ENST00000396819.3
|
latent transforming growth factor beta binding protein 4 |
|
| chr16_-_70472946 Show fit | 1.27 |
ENST00000342907.2
|
ST3 beta-galactoside alpha-2,3-sialyltransferase 2 |
|
| chr19_-_50381606 Show fit | 1.26 |
ENST00000391830.1
|
AKT1 substrate 1 (proline-rich) |
|
| chr14_-_77495007 Show fit | 1.17 |
ENST00000238647.3
|
interferon regulatory factor 2 binding protein-like |
Network of associatons between targets according to the STRING database.
First level regulatory network of EBF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.6 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.1 | 3.3 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.3 | 2.6 | GO:0002159 | desmosome assembly(GO:0002159) |
| 0.2 | 2.3 | GO:0060056 | mammary gland involution(GO:0060056) |
| 0.0 | 2.2 | GO:1902017 | regulation of cilium assembly(GO:1902017) |
| 0.4 | 2.1 | GO:1904274 | tricellular tight junction assembly(GO:1904274) |
| 0.3 | 2.1 | GO:0061143 | alveolar primary septum development(GO:0061143) |
| 0.2 | 2.0 | GO:1990822 | basic amino acid transmembrane transport(GO:1990822) |
| 0.0 | 2.0 | GO:0010257 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.4 | 1.8 | GO:0032218 | riboflavin transport(GO:0032218) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.1 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 3.6 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 2.3 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.2 | 2.0 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.1 | 2.0 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.1 | 1.8 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.0 | 1.6 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 1.6 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 1.6 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 1.4 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.4 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.1 | 3.0 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.2 | 2.1 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.0 | 2.1 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 2.1 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 0.1 | 2.0 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
| 0.1 | 1.9 | GO:0051183 | vitamin transporter activity(GO:0051183) |
| 0.4 | 1.8 | GO:0032217 | riboflavin transporter activity(GO:0032217) |
| 0.1 | 1.7 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.4 | 1.6 | GO:0033981 | D-dopachrome decarboxylase activity(GO:0033981) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.3 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 3.1 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 1.8 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 1.8 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 1.6 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 1.6 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 1.0 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 1.0 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 1.0 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.0 | 0.9 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.3 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 2.7 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 2.2 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 2.1 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.0 | 2.1 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.1 | 1.6 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.0 | 1.6 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.0 | 1.6 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 1.2 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 1.1 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |