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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for E2F7_E2F1
Z-value: 1.05
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Transcription factors associated with E2F7_E2F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F1 | hg19_v2_chr20_-_32274179_32274213 | -0.92 | 8.2e-02 | Click! |
| E2F7 | hg19_v2_chr12_-_77459306_77459365 | 0.52 | 4.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F7_E2F1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.6 | GO:1903461 | Okazaki fragment processing involved in mitotic DNA replication(GO:1903461) |
| 0.1 | 1.3 | GO:0000722 | telomere maintenance via recombination(GO:0000722) |
| 0.2 | 1.1 | GO:0046604 | positive regulation of mitotic centrosome separation(GO:0046604) |
| 0.0 | 1.1 | GO:0061014 | positive regulation of mRNA catabolic process(GO:0061014) |
| 0.0 | 0.8 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.0 | 0.8 | GO:0030049 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 0.0 | 0.8 | GO:0008333 | endosome to lysosome transport(GO:0008333) |
| 0.2 | 0.7 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
| 0.2 | 0.7 | GO:1901254 | modulation by host of viral RNA genome replication(GO:0044830) positive regulation of intracellular transport of viral material(GO:1901254) |
| 0.1 | 0.7 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 0.9 | GO:0005663 | DNA replication factor C complex(GO:0005663) |
| 0.1 | 0.8 | GO:0016589 | NURF complex(GO:0016589) |
| 0.1 | 0.8 | GO:0000796 | condensin complex(GO:0000796) |
| 0.0 | 0.8 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.2 | 0.7 | GO:1902737 | dendritic filopodium(GO:1902737) |
| 0.1 | 0.7 | GO:0035061 | interchromatin granule(GO:0035061) |
| 0.0 | 0.7 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.0 | 0.7 | GO:0070822 | Sin3-type complex(GO:0070822) |
| 0.1 | 0.6 | GO:0031510 | SUMO activating enzyme complex(GO:0031510) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.0 | GO:0003910 | DNA ligase (ATP) activity(GO:0003910) |
| 0.0 | 1.1 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.1 | 1.0 | GO:0034046 | poly(G) binding(GO:0034046) |
| 0.0 | 0.8 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 0.7 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 0.1 | 0.7 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
| 0.0 | 0.7 | GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) |
| 0.0 | 0.7 | GO:0043047 | single-stranded telomeric DNA binding(GO:0043047) |
| 0.1 | 0.6 | GO:0032143 | single thymine insertion binding(GO:0032143) |
| 0.1 | 0.6 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 1.4 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 0.9 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 0.9 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 0.7 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 0.7 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 0.6 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 0.6 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 0.6 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 0.4 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | REACTOME LAGGING STRAND SYNTHESIS | Genes involved in Lagging Strand Synthesis |
| 0.1 | 2.0 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.0 | 1.1 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 1.1 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 0.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 0.7 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 0.7 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 0.6 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.0 | 0.5 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.0 | 0.5 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |