ISMARA results: E2F6

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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for E2F6

Z-value: 2.26

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Transcription factors associated with E2F6

Gene Symbol	Gene ID	Gene Info
E2F6 Ensembl NCBI GeneCards UniProt	ENSG00000169016.12	E2F transcription factor 6

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
E2F6	hg19_v2_chr2_-_11605966_11606005	0.58	4.2e-01	Click!

Activity profile of E2F6 motif

Sorted Z-values of E2F6 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_-_48673465 Show fit	1.90	ENST00000598938.1	LIG1 Ensembl NCBI GeneCards UniProt Show fit	ligase I, DNA, ATP-dependent
chr11_-_46142615 Show fit	1.34	ENST00000529734.1 ENST00000323180.6	PHF21A Ensembl NCBI GeneCards UniProt Show fit	PHD finger protein 21A
chr2_+_112895939 Show fit	1.21	ENST00000331203.2 ENST00000409903.1 ENST00000409667.3 ENST00000409450.3	FBLN7 Ensembl NCBI GeneCards UniProt Show fit	fibulin 7
chr19_+_55795493 Show fit	1.20	ENST00000309383.1	BRSK1 Ensembl NCBI GeneCards UniProt Show fit	BR serine/threonine kinase 1
chr6_+_154360616 Show fit	1.10	ENST00000229768.5 ENST00000419506.2 ENST00000524163.1 ENST00000414028.2 ENST00000435918.2 ENST00000337049.4	OPRM1 Ensembl NCBI GeneCards UniProt Show fit	opioid receptor, mu 1
chr3_-_113415441 Show fit	1.03	ENST00000491165.1 ENST00000316407.4	KIAA2018 Ensembl NCBI GeneCards UniProt Show fit	KIAA2018
chr12_-_57824561 Show fit	1.02	ENST00000448732.1	R3HDM2 Ensembl NCBI GeneCards UniProt Show fit	R3H domain containing 2
chr5_+_61602236 Show fit	0.96	ENST00000514082.1 ENST00000407818.3	KIF2A Ensembl NCBI GeneCards UniProt Show fit	kinesin heavy chain member 2A
chr1_+_211433275 Show fit	0.94	ENST00000367005.4	RCOR3 Ensembl NCBI GeneCards UniProt Show fit	REST corepressor 3
chr12_-_104531785 Show fit	0.86	ENST00000551727.1	NFYB Ensembl NCBI GeneCards UniProt Show fit	nuclear transcription factor Y, beta

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F6

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	2.6	GO:1903461	Okazaki fragment processing involved in mitotic DNA replication(GO:1903461)
0.0	2.6	GO:0006476	protein deacetylation(GO:0006476)
0.3	2.1	GO:1903588	negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.3	1.8	GO:0010166	wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.1	1.8	GO:2000675	negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.0	1.8	GO:1902850	microtubule cytoskeleton organization involved in mitosis(GO:1902850)
0.0	1.7	GO:0070911	global genome nucleotide-excision repair(GO:0070911)
0.1	1.5	GO:0031441	negative regulation of mRNA 3'-end processing(GO:0031441)
0.5	1.4	GO:0044830	modulation by host of viral RNA genome replication(GO:0044830) positive regulation of intracellular transport of viral material(GO:1901254)
0.1	1.4	GO:0032515	negative regulation of phosphoprotein phosphatase activity(GO:0032515)

Showing 1 to 10 of 642 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.9	GO:0016607	nuclear speck(GO:0016607)
0.0	3.3	GO:0043197	dendritic spine(GO:0043197)
0.0	2.9	GO:0036064	ciliary basal body(GO:0036064)
0.1	2.8	GO:0005849	mRNA cleavage factor complex(GO:0005849)
0.0	2.5	GO:0017053	transcriptional repressor complex(GO:0017053)
0.1	2.4	GO:0070822	Sin3-type complex(GO:0070822)
0.0	2.4	GO:1990391	DNA repair complex(GO:1990391)
0.0	2.4	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.2	2.2	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.2	2.1	GO:0016589	NURF complex(GO:0016589)

Showing 1 to 10 of 255 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.5	GO:0004407	histone deacetylase activity(GO:0004407)
0.2	3.0	GO:0003910	DNA ligase (ATP) activity(GO:0003910)
0.1	2.2	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.3	2.0	GO:0034046	poly(G) binding(GO:0034046)
0.0	1.9	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.3	1.8	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0	1.8	GO:0070717	poly-purine tract binding(GO:0070717)
0.0	1.8	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.2	1.7	GO:0010859	calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.1	1.7	GO:0008140	cAMP response element binding protein binding(GO:0008140)

Showing 1 to 10 of 382 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.9	PID PLK1 PATHWAY	PLK1 signaling events
0.0	3.5	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.0	3.2	PID RAC1 PATHWAY	RAC1 signaling pathway
0.0	2.9	PID BARD1 PATHWAY	BARD1 signaling events
0.1	2.4	PID ALK1 PATHWAY	ALK1 signaling events
0.0	2.4	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.0	2.2	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.0	2.1	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.1	1.8	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	1.8	PID AP1 PATHWAY	AP-1 transcription factor network

Showing 1 to 10 of 71 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.5	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.0	3.4	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.1	3.3	REACTOME EARLY PHASE OF HIV LIFE CYCLE	Genes involved in Early Phase of HIV Life Cycle
0.1	3.3	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.1	2.9	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.0	2.6	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.0	2.3	REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN	Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0	2.3	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.1	2.1	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.0	2.1	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling

Showing 1 to 10 of 112 entries

Results for E2F6

Z-value: 2.26

Motif logo

Transcription factors associated with E2F6

Activity-expression correlation:

Activity profile of E2F6 motif

Sorted Z-values of E2F6 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F6

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: