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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for E2F4
Z-value: 1.45
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Transcription factors associated with E2F4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F4 | hg19_v2_chr16_+_67226019_67226127 | -0.92 | 8.0e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_48673465 Show fit | 0.86 |
ENST00000598938.1
|
ligase I, DNA, ATP-dependent |
|
| chr2_+_71357434 Show fit | 0.84 |
ENST00000244230.2
|
M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) |
|
| chr15_-_71184724 Show fit | 0.77 |
ENST00000560604.1
|
THAP domain containing 10 |
|
| chr2_+_29033682 Show fit | 0.71 |
ENST00000379579.4
ENST00000334056.5 ENST00000449210.1 |
speedy/RINGO cell cycle regulator family member A |
|
| chr2_+_71357744 Show fit | 0.60 |
ENST00000498451.2
|
M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) |
|
| chr3_+_180630444 Show fit | 0.59 |
ENST00000491062.1
ENST00000468861.1 ENST00000445140.2 ENST00000484958.1 |
fragile X mental retardation, autosomal homolog 1 |
|
| chr5_-_43313574 Show fit | 0.56 |
ENST00000325110.6
ENST00000433297.2 |
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) |
|
| chr9_-_113018746 Show fit | 0.54 |
ENST00000374515.5
|
thioredoxin |
|
| chr2_-_11484710 Show fit | 0.48 |
ENST00000315872.6
|
Rho-associated, coiled-coil containing protein kinase 2 |
|
| chr1_+_185014647 Show fit | 0.47 |
ENST00000367509.4
|
ring finger protein 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | GO:0030490 | maturation of SSU-rRNA(GO:0030490) |
| 0.4 | 1.1 | GO:1903461 | Okazaki fragment processing involved in mitotic DNA replication(GO:1903461) |
| 0.1 | 1.0 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus(GO:0071372) |
| 0.1 | 0.9 | GO:0036353 | histone H2A-K119 monoubiquitination(GO:0036353) |
| 0.1 | 0.8 | GO:0060339 | negative regulation of type I interferon-mediated signaling pathway(GO:0060339) |
| 0.1 | 0.8 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
| 0.1 | 0.8 | GO:0046826 | negative regulation of protein export from nucleus(GO:0046826) |
| 0.0 | 0.8 | GO:0010457 | centriole-centriole cohesion(GO:0010457) |
| 0.0 | 0.8 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 0.0 | 0.8 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.4 | GO:0034457 | Mpp10 complex(GO:0034457) |
| 0.0 | 1.1 | GO:0043034 | costamere(GO:0043034) |
| 0.3 | 0.8 | GO:0075341 | host cell PML body(GO:0075341) |
| 0.2 | 0.8 | GO:0032301 | MutSalpha complex(GO:0032301) |
| 0.1 | 0.8 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
| 0.0 | 0.8 | GO:0000800 | lateral element(GO:0000800) |
| 0.1 | 0.7 | GO:0001739 | sex chromatin(GO:0001739) |
| 0.0 | 0.7 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.1 | 0.6 | GO:0031510 | SUMO activating enzyme complex(GO:0031510) |
| 0.1 | 0.6 | GO:0035061 | interchromatin granule(GO:0035061) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | GO:0033592 | RNA strand annealing activity(GO:0033592) |
| 0.1 | 1.1 | GO:0003910 | DNA ligase (ATP) activity(GO:0003910) |
| 0.1 | 1.0 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 0.1 | 1.0 | GO:0047134 | protein-disulfide reductase activity(GO:0047134) |
| 0.1 | 0.9 | GO:0071535 | RING-like zinc finger domain binding(GO:0071535) |
| 0.1 | 0.9 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.0 | 0.9 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.3 | 0.8 | GO:0071207 | histone pre-mRNA stem-loop binding(GO:0071207) |
| 0.2 | 0.8 | GO:0032143 | single thymine insertion binding(GO:0032143) |
| 0.1 | 0.7 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 1.1 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 0.9 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.9 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 0.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.8 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 0.7 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 0.5 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 0.4 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 0.3 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | REACTOME LAGGING STRAND SYNTHESIS | Genes involved in Lagging Strand Synthesis |
| 0.1 | 1.0 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 0.0 | 1.0 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 1.0 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 0.8 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 0.8 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.0 | 0.8 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.7 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 0.7 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 0.7 | REACTOME SIGNALING BY FGFR1 MUTANTS | Genes involved in Signaling by FGFR1 mutants |