ISMARA results: E2F3

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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for E2F3

Z-value: 2.93

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Transcription factors associated with E2F3

Gene Symbol	Gene ID	Gene Info
E2F3 Ensembl NCBI GeneCards UniProt	ENSG00000112242.10	E2F transcription factor 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
E2F3	hg19_v2_chr6_+_20403997_20404034	0.75	2.5e-01	Click!

Activity profile of E2F3 motif

Sorted Z-values of E2F3 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_+_128982416 Show fit	1.32	ENST00000326639.6	LARP1B Ensembl NCBI GeneCards UniProt Show fit	La ribonucleoprotein domain family, member 1B
chr15_+_83776324 Show fit	1.24	ENST00000379390.6 ENST00000379386.4 ENST00000565774.1 ENST00000565982.1	TM6SF1 Ensembl NCBI GeneCards UniProt Show fit	transmembrane 6 superfamily member 1
chr1_-_54411240 Show fit	1.21	ENST00000371378.2	HSPB11 Ensembl NCBI GeneCards UniProt Show fit	heat shock protein family B (small), member 11
chr14_+_104029362 Show fit	1.21	ENST00000495778.1	APOPT1 Ensembl NCBI GeneCards UniProt Show fit	apoptogenic 1, mitochondrial
chr2_-_232328867 Show fit	1.17	ENST00000453992.1 ENST00000417652.1 ENST00000454824.1	NCL Ensembl NCBI GeneCards UniProt Show fit	nucleolin
chr19_-_48673465 Show fit	1.15	ENST00000598938.1	LIG1 Ensembl NCBI GeneCards UniProt Show fit	ligase I, DNA, ATP-dependent
chr12_-_104531785 Show fit	1.10	ENST00000551727.1	NFYB Ensembl NCBI GeneCards UniProt Show fit	nuclear transcription factor Y, beta
chr19_-_14628645 Show fit	1.10	ENST00000598235.1	DNAJB1 Ensembl NCBI GeneCards UniProt Show fit	DnaJ (Hsp40) homolog, subfamily B, member 1
chr10_+_15001430 Show fit	1.03	ENST00000407572.1	MEIG1 Ensembl NCBI GeneCards UniProt Show fit	meiosis/spermiogenesis associated 1
chr2_-_203103185 Show fit	1.00	ENST00000409205.1	SUMO1 Ensembl NCBI GeneCards UniProt Show fit	small ubiquitin-like modifier 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.3	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0	2.9	GO:0070126	mitochondrial translational termination(GO:0070126)
0.0	2.4	GO:1990830	response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.2	2.0	GO:0034393	positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.1	2.0	GO:0070986	left/right axis specification(GO:0070986)
0.1	1.9	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	1.9	GO:0038128	ERBB2 signaling pathway(GO:0038128)
0.1	1.8	GO:1901838	positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.6	1.7	GO:1901896	positive regulation of calcium-transporting ATPase activity(GO:1901896)
0.1	1.7	GO:0070389	chaperone cofactor-dependent protein refolding(GO:0070389)

Showing 1 to 10 of 618 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.5	GO:0005938	cell cortex(GO:0005938)
0.1	3.7	GO:1902711	GABA-A receptor complex(GO:1902711)
0.1	2.7	GO:0030992	intraciliary transport particle B(GO:0030992)
0.2	2.3	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.1	2.3	GO:0005763	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.4	2.2	GO:0031510	SUMO activating enzyme complex(GO:0031510)
0.1	2.2	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0	2.2	GO:0005801	cis-Golgi network(GO:0005801)
0.1	1.9	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	1.8	GO:0005782	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)

Showing 1 to 10 of 264 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.9	GO:0001103	RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1	3.7	GO:0004890	GABA-A receptor activity(GO:0004890)
0.4	3.3	GO:0044388	small protein activating enzyme binding(GO:0044388)
0.0	3.2	GO:0051082	unfolded protein binding(GO:0051082)
0.0	2.6	GO:0003899	DNA-directed RNA polymerase activity(GO:0003899)
0.0	2.6	GO:0019003	GDP binding(GO:0019003)
0.0	2.6	GO:0047485	protein N-terminus binding(GO:0047485)
0.2	2.2	GO:0000774	adenyl-nucleotide exchange factor activity(GO:0000774)
0.1	2.0	GO:0008143	poly(A) binding(GO:0008143)
0.0	2.0	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)

Showing 1 to 10 of 420 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.4	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	4.6	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.1	2.6	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.1	2.5	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.0	2.5	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	2.5	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.1	2.3	PID BARD1 PATHWAY	BARD1 signaling events
0.0	2.3	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.0	2.1	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	2.1	PID TELOMERASE PATHWAY	Regulation of Telomerase

Showing 1 to 10 of 56 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.9	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.1	3.5	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.1	3.0	REACTOME PROCESSING OF INTRONLESS PRE MRNAS	Genes involved in Processing of Intronless Pre-mRNAs
0.0	2.9	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1	2.7	REACTOME EARLY PHASE OF HIV LIFE CYCLE	Genes involved in Early Phase of HIV Life Cycle
0.0	2.7	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.2	2.4	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1	2.2	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	2.1	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.0	2.0	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism

Showing 1 to 10 of 109 entries

Results for E2F3

Z-value: 2.93

Motif logo

Transcription factors associated with E2F3

Activity-expression correlation:

Activity profile of E2F3 motif

Sorted Z-values of E2F3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: