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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for E2F2_E2F5
Z-value: 1.53
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Transcription factors associated with E2F2_E2F5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F5 | hg19_v2_chr8_+_86099884_86099920 | 0.97 | 3.5e-02 | Click! |
| E2F2 | hg19_v2_chr1_-_23857698_23857733 | -0.73 | 2.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_27833034 Show fit | 1.32 |
ENST00000357320.2
|
histone cluster 1, H2al |
|
| chr6_+_27782788 Show fit | 0.76 |
ENST00000359465.4
|
histone cluster 1, H2bm |
|
| chr6_+_24775641 Show fit | 0.73 |
ENST00000378054.2
ENST00000476555.1 |
geminin, DNA replication inhibitor |
|
| chr1_-_91487013 Show fit | 0.64 |
ENST00000347275.5
ENST00000370440.1 |
zinc finger protein 644 |
|
| chr11_-_19263145 Show fit | 0.63 |
ENST00000532666.1
ENST00000527884.1 |
E2F transcription factor 8 |
|
| chr11_-_95522907 Show fit | 0.59 |
ENST00000358780.5
ENST00000542135.1 |
family with sequence similarity 76, member B |
|
| chr15_-_71184724 Show fit | 0.56 |
ENST00000560604.1
|
THAP domain containing 10 |
|
| chr14_+_36295638 Show fit | 0.56 |
ENST00000543183.1
|
breast cancer metastasis-suppressor 1-like |
|
| chr11_-_95522639 Show fit | 0.52 |
ENST00000536839.1
|
family with sequence similarity 76, member B |
|
| chr18_+_19192228 Show fit | 0.48 |
ENST00000300413.5
ENST00000579618.1 ENST00000582475.1 |
small nuclear ribonucleoprotein D1 polypeptide 16kDa |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F2_E2F5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.1 | GO:0046604 | positive regulation of mitotic centrosome separation(GO:0046604) |
| 0.3 | 1.0 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
| 0.1 | 1.0 | GO:0071163 | DNA replication preinitiation complex assembly(GO:0071163) |
| 0.1 | 0.9 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 0.1 | 0.8 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 0.2 | 0.7 | GO:1990426 | homologous recombination-dependent replication fork processing(GO:1990426) |
| 0.1 | 0.7 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 0.0 | 0.7 | GO:1900112 | regulation of histone H3-K9 trimethylation(GO:1900112) |
| 0.2 | 0.6 | GO:1901896 | positive regulation of calcium-transporting ATPase activity(GO:1901896) |
| 0.1 | 0.6 | GO:0007000 | nucleolus organization(GO:0007000) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.1 | 0.9 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.0 | 0.8 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 0.7 | GO:0000800 | lateral element(GO:0000800) |
| 0.0 | 0.7 | GO:0070822 | Sin3-type complex(GO:0070822) |
| 0.1 | 0.6 | GO:0031510 | SUMO activating enzyme complex(GO:0031510) |
| 0.1 | 0.5 | GO:0097362 | MCM8-MCM9 complex(GO:0097362) |
| 0.1 | 0.5 | GO:0032301 | MutSalpha complex(GO:0032301) |
| 0.1 | 0.5 | GO:0034715 | pICln-Sm protein complex(GO:0034715) |
| 0.0 | 0.5 | GO:0070652 | HAUS complex(GO:0070652) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.0 | 1.1 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.1 | 0.9 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.1 | 0.6 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 0.1 | 0.6 | GO:0044388 | small protein activating enzyme binding(GO:0044388) |
| 0.1 | 0.6 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
| 0.0 | 0.6 | GO:0043142 | single-stranded DNA-dependent ATPase activity(GO:0043142) |
| 0.2 | 0.5 | GO:0051870 | methotrexate binding(GO:0051870) |
| 0.1 | 0.5 | GO:0036033 | mediator complex binding(GO:0036033) |
| 0.1 | 0.5 | GO:0032143 | single thymine insertion binding(GO:0032143) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 1.6 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 0.8 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.7 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 0.6 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.2 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.0 | 1.2 | REACTOME RNA POL I TRANSCRIPTION | Genes involved in RNA Polymerase I Transcription |
| 0.0 | 1.1 | REACTOME LATE PHASE OF HIV LIFE CYCLE | Genes involved in Late Phase of HIV Life Cycle |
| 0.0 | 0.8 | REACTOME ELONGATION ARREST AND RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.0 | 0.7 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.0 | 0.6 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.0 | 0.6 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.0 | 0.5 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 0.5 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.0 | 0.5 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |