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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for CREB5_CREM_JUNB
Z-value: 0.93
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Transcription factors associated with CREB5_CREM_JUNB
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000146592.12 | cAMP responsive element binding protein 5 | |
| ENSG00000095794.15 | cAMP responsive element modulator | |
| ENSG00000171223.4 | JunB proto-oncogene, AP-1 transcription factor subunit |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| JUNB | hg19_v2_chr19_+_12902289_12902310 | -0.99 | 5.1e-03 | Click! |
| CREB5 | hg19_v2_chr7_+_28725585_28725608 | -0.92 | 8.0e-02 | Click! |
| CREM | hg19_v2_chr10_+_35456444_35456498 | 0.91 | 8.9e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CREB5_CREM_JUNB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.4 | GO:0002318 | myeloid progenitor cell differentiation(GO:0002318) |
| 0.0 | 1.3 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.1 | 1.2 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.1 | 1.0 | GO:2000286 | receptor internalization involved in canonical Wnt signaling pathway(GO:2000286) |
| 0.1 | 1.0 | GO:1902412 | regulation of mitotic cytokinesis(GO:1902412) |
| 0.0 | 1.0 | GO:0032515 | negative regulation of phosphoprotein phosphatase activity(GO:0032515) |
| 0.3 | 0.9 | GO:0017186 | peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186) |
| 0.1 | 0.9 | GO:0007079 | mitotic chromosome movement towards spindle pole(GO:0007079) |
| 0.0 | 0.9 | GO:0070262 | peptidyl-serine dephosphorylation(GO:0070262) |
| 0.1 | 0.8 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.1 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.0 | 1.5 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 1.1 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.1 | 0.9 | GO:0000322 | storage vacuole(GO:0000322) |
| 0.0 | 0.9 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.0 | 0.9 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 0.8 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.1 | 0.7 | GO:0034274 | Atg12-Atg5-Atg16 complex(GO:0034274) |
| 0.0 | 0.7 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.0 | 0.7 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.2 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 1.2 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 1.2 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 1.1 | GO:0031210 | phosphatidylcholine binding(GO:0031210) |
| 0.0 | 1.1 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 1.0 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.3 | 0.9 | GO:0016603 | glutaminyl-peptide cyclotransferase activity(GO:0016603) |
| 0.1 | 0.9 | GO:0043515 | kinetochore binding(GO:0043515) |
| 0.0 | 0.9 | GO:0008603 | cAMP-dependent protein kinase regulator activity(GO:0008603) |
| 0.0 | 0.9 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 1.2 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 1.0 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 0.9 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 0.8 | PID S1P S1P2 PATHWAY | S1P2 pathway |
| 0.0 | 0.8 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.6 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 0.5 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.5 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.5 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.0 | 1.0 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 0.9 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 0.8 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 0.8 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.0 | 0.8 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 0.7 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 0.7 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 0.6 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.0 | 0.6 | REACTOME SIGNALLING TO P38 VIA RIT AND RIN | Genes involved in Signalling to p38 via RIT and RIN |