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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for BRCA1

Z-value: 0.26

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Transcription factors associated with BRCA1

Gene Symbol Gene ID Gene Info
ENSG00000012048.15 BRCA1 DNA repair associated

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BRCA1hg19_v2_chr17_-_41277317_412773480.954.8e-02Click!

Activity profile of BRCA1 motif

Sorted Z-values of BRCA1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_67141640 0.17 ENST00000533438.1
cardiotrophin-like cytokine factor 1
chr8_+_37553261 0.14 ENST00000331569.4
zinc finger protein 703
chrX_-_70288234 0.13 ENST00000276105.3
ENST00000374274.3
sorting nexin 12
chr17_+_21730180 0.12 ENST00000584398.1
ubiquitin B pseudogene 4
chr19_-_40324767 0.10 ENST00000601972.1
ENST00000430012.2
ENST00000323039.5
ENST00000348817.3
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
chr17_-_27230035 0.09 ENST00000378895.4
ENST00000394901.3
dehydrogenase/reductase (SDR family) member 13
chr14_+_32030582 0.09 ENST00000550649.1
ENST00000281081.7
nucleotide binding protein-like
chr14_-_69261310 0.08 ENST00000336440.3
ZFP36 ring finger protein-like 1
chr12_-_49449107 0.06 ENST00000301067.7
lysine (K)-specific methyltransferase 2D
chr10_+_104404644 0.06 ENST00000462202.2
tripartite motif containing 8
chr5_+_139493665 0.06 ENST00000331327.3
purine-rich element binding protein A
chr17_-_56296580 0.06 ENST00000313863.6
ENST00000546108.1
ENST00000337050.7
ENST00000393119.2
Meckel syndrome, type 1
chr2_+_196522032 0.06 ENST00000418005.1
solute carrier family 39 (zinc transporter), member 10
chrX_-_77150911 0.06 ENST00000373336.3
magnesium transporter 1
chr17_+_36584662 0.06 ENST00000431231.2
ENST00000437668.3
Rho GTPase activating protein 23
chr3_+_184056614 0.05 ENST00000453072.1
family with sequence similarity 131, member A
chr2_+_108994466 0.05 ENST00000272452.2
sulfotransferase family, cytosolic, 1C, member 4
chr1_+_70687137 0.05 ENST00000436161.2
serine/arginine-rich splicing factor 11
chr7_+_99717230 0.05 ENST00000262932.3
canopy FGF signaling regulator 4
chr5_+_140186647 0.05 ENST00000512229.2
ENST00000356878.4
ENST00000530339.1
protocadherin alpha 4
chr12_-_49418407 0.05 ENST00000526209.1
lysine (K)-specific methyltransferase 2D
chr1_-_160232197 0.04 ENST00000419626.1
ENST00000610139.1
ENST00000475733.1
ENST00000407642.2
ENST00000368073.3
ENST00000326837.2
DDB1 and CUL4 associated factor 8
chr8_-_116681123 0.04 ENST00000519674.1
trichorhinophalangeal syndrome I
chr16_-_790982 0.04 ENST00000301694.5
ENST00000251588.2
nuclear prelamin A recognition factor-like
chr7_-_99716952 0.04 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr3_-_127455200 0.04 ENST00000398101.3
monoglyceride lipase
chr10_-_75385711 0.04 ENST00000433394.1
ubiquitin specific peptidase 54
chr6_+_42981922 0.04 ENST00000326974.4
ENST00000244670.8
kelch domain containing 3
chrX_+_150565038 0.04 ENST00000370361.1
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
chr8_+_22462532 0.03 ENST00000389279.3
cell cycle and apoptosis regulator 2
chr10_+_102295616 0.03 ENST00000299163.6
hypoxia inducible factor 1, alpha subunit inhibitor
chr6_+_12717892 0.03 ENST00000379350.1
phosphatase and actin regulator 1
chr9_-_86593238 0.03 ENST00000351839.3
heterogeneous nuclear ribonucleoprotein K
chr10_-_102289611 0.03 ENST00000299166.4
ENST00000370320.4
ENST00000531258.1
ENST00000370322.1
ENST00000535773.1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
SEC31 homolog B (S. cerevisiae)
chr19_+_45394477 0.03 ENST00000252487.5
ENST00000405636.2
ENST00000592434.1
ENST00000426677.2
ENST00000589649.1
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr1_-_160232291 0.03 ENST00000368074.1
ENST00000447377.1
DDB1 and CUL4 associated factor 8
chr6_-_42981651 0.03 ENST00000244711.3
male-enhanced antigen 1
chr8_-_116681221 0.03 ENST00000395715.3
trichorhinophalangeal syndrome I
chr5_-_124082279 0.03 ENST00000513986.1
zinc finger protein 608
chr15_+_67430339 0.03 ENST00000439724.3
SMAD family member 3
chr6_-_25832254 0.03 ENST00000476801.1
ENST00000244527.4
ENST00000427328.1
solute carrier family 17 (organic anion transporter), member 1
chr8_+_97773202 0.03 ENST00000519484.1
carboxypeptidase Q
chr15_-_88799948 0.03 ENST00000394480.2
neurotrophic tyrosine kinase, receptor, type 3
chr6_-_137314371 0.03 ENST00000432330.1
ENST00000418699.1
RP11-55K22.5
chr16_-_790887 0.02 ENST00000540986.1
nuclear prelamin A recognition factor-like
chr19_-_37663572 0.02 ENST00000588354.1
ENST00000292841.5
ENST00000355533.2
ENST00000356958.4
zinc finger protein 585A
chr17_+_74372662 0.02 ENST00000591651.1
ENST00000545180.1
sphingosine kinase 1
chr19_-_48389651 0.02 ENST00000222002.3
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr14_-_75179774 0.02 ENST00000555249.1
ENST00000556202.1
ENST00000356357.4
ENST00000338772.5
apoptosis resistant E3 ubiquitin protein ligase 1
Full-length cDNA 5-PRIME end of clone CS0CAP004YO05 of Thymus of Homo sapiens (human); Uncharacterized protein
chr1_-_173020056 0.02 ENST00000239468.2
ENST00000404377.3
tumor necrosis factor (ligand) superfamily, member 18
chr2_-_179914760 0.02 ENST00000420890.2
ENST00000409284.1
ENST00000443758.1
ENST00000446116.1
coiled-coil domain containing 141
chr10_-_61900762 0.02 ENST00000355288.2
ankyrin 3, node of Ranvier (ankyrin G)
chr10_+_122610853 0.02 ENST00000604585.1
WD repeat domain 11
chr6_+_33172407 0.02 ENST00000374662.3
hydroxysteroid (17-beta) dehydrogenase 8
chr11_+_47291193 0.02 ENST00000428807.1
ENST00000402799.1
ENST00000406482.1
ENST00000349238.3
ENST00000311027.5
ENST00000407859.3
ENST00000395344.3
ENST00000444117.1
MAP-kinase activating death domain
chr19_-_37663332 0.02 ENST00000392157.2
zinc finger protein 585A
chr13_+_27825446 0.02 ENST00000311549.6
ribosomal protein L21
chrX_+_10124977 0.02 ENST00000380833.4
chloride channel, voltage-sensitive 4
chr8_+_22022800 0.02 ENST00000397814.3
bone morphogenetic protein 1
chr3_+_185303962 0.01 ENST00000296257.5
SUMO1/sentrin/SMT3 specific peptidase 2
chr7_-_99716940 0.01 ENST00000440225.1
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr8_+_22022653 0.01 ENST00000354870.5
ENST00000397816.3
ENST00000306349.8
bone morphogenetic protein 1
chr1_-_170043709 0.01 ENST00000367767.1
ENST00000361580.2
ENST00000538366.1
kinesin-associated protein 3
chr5_+_139027877 0.01 ENST00000302517.3
CXXC finger protein 5
chr6_-_170862322 0.01 ENST00000262193.6
proteasome (prosome, macropain) subunit, beta type, 1
chr10_+_122610687 0.01 ENST00000263461.6
WD repeat domain 11
chrX_+_49644470 0.01 ENST00000508866.2
ubiquitin specific peptidase 27, X-linked
chr7_+_44646177 0.01 ENST00000443864.2
ENST00000447398.1
ENST00000449767.1
ENST00000419661.1
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr7_+_44646162 0.01 ENST00000439616.2
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr19_+_46000479 0.01 ENST00000456399.2
protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)
chr17_+_36908984 0.01 ENST00000225426.4
ENST00000579088.1
proteasome (prosome, macropain) subunit, beta type, 3
chr1_+_10271674 0.01 ENST00000377086.1
kinesin family member 1B
chr12_+_122880045 0.01 ENST00000539034.1
ENST00000535976.1
RP11-450K4.1
chr1_-_115301235 0.00 ENST00000525878.1
cold shock domain containing E1, RNA-binding
chr3_-_176914191 0.00 ENST00000437738.1
ENST00000424913.1
ENST00000443315.1
transducin (beta)-like 1 X-linked receptor 1
chr2_-_158182410 0.00 ENST00000419116.2
ENST00000410096.1
ermin, ERM-like protein
chr2_-_158182105 0.00 ENST00000409925.1
ermin, ERM-like protein
chr1_+_70687079 0.00 ENST00000395136.2
serine/arginine-rich splicing factor 11
chr8_+_97773457 0.00 ENST00000521142.1
carboxypeptidase Q
chr2_-_158182322 0.00 ENST00000420719.2
ENST00000409216.1
ermin, ERM-like protein
chr19_+_55888186 0.00 ENST00000291934.3
transmembrane protein 190
chr2_-_152118352 0.00 ENST00000331426.5
RNA binding motif protein 43
chr10_-_95209 0.00 ENST00000332708.5
ENST00000309812.4
tubulin, beta 8 class VIII
chr2_+_203879568 0.00 ENST00000449802.1
neurobeachin-like 1

Network of associatons between targets according to the STRING database.

First level regulatory network of BRCA1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
0.0 0.2 GO:0048295 positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.0 0.1 GO:0001555 oocyte growth(GO:0001555)
0.0 0.1 GO:1901545 cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.0 GO:0044609 DBIRD complex(GO:0044609)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)