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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for ATF4
Z-value: 0.95
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Transcription factors associated with ATF4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ATF4 | hg19_v2_chr22_+_39916558_39916579 | 0.87 | 1.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_+_41245160 Show fit | 1.28 |
ENST00000444189.2
ENST00000446533.3 |
ChaC, cation transport regulator homolog 1 (E. coli) |
|
| chr1_+_149804218 Show fit | 0.89 |
ENST00000610125.1
|
histone cluster 2, H4a |
|
| chr17_-_40828969 Show fit | 0.58 |
ENST00000591022.1
ENST00000587627.1 ENST00000293349.6 |
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 |
|
| chr16_-_87812735 Show fit | 0.56 |
ENST00000570159.1
|
RP4-536B24.4 |
|
| chr17_+_73089382 Show fit | 0.51 |
ENST00000538213.2
ENST00000584118.1 |
solute carrier family 16 (monocarboxylate transporter), member 5 |
|
| chr19_-_47288162 Show fit | 0.45 |
ENST00000594991.1
|
solute carrier family 1 (neutral amino acid transporter), member 5 |
|
| chr17_-_40829026 Show fit | 0.42 |
ENST00000412503.1
|
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 |
|
| chr12_-_117318788 Show fit | 0.42 |
ENST00000550505.1
|
harakiri, BCL2 interacting protein (contains only BH3 domain) |
|
| chr19_-_47287990 Show fit | 0.41 |
ENST00000593713.1
ENST00000598022.1 ENST00000434726.2 |
solute carrier family 1 (neutral amino acid transporter), member 5 |
|
| chr12_+_57914481 Show fit | 0.40 |
ENST00000548887.1
|
methyl-CpG binding domain protein 6 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ATF4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | GO:0006751 | glutathione catabolic process(GO:0006751) |
| 0.1 | 1.0 | GO:0019264 | glycine biosynthetic process from serine(GO:0019264) |
| 0.2 | 0.9 | GO:0010585 | glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803) |
| 0.1 | 0.6 | GO:0055129 | L-proline biosynthetic process(GO:0055129) |
| 0.1 | 0.5 | GO:0006116 | NADH oxidation(GO:0006116) |
| 0.1 | 0.4 | GO:0090427 | activation of meiosis(GO:0090427) |
| 0.1 | 0.4 | GO:0017143 | insecticide metabolic process(GO:0017143) cellular response to luteinizing hormone stimulus(GO:0071373) |
| 0.1 | 0.4 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.0 | 0.4 | GO:0032464 | positive regulation of protein homooligomerization(GO:0032464) |
| 0.1 | 0.3 | GO:0060381 | regulation of single-stranded telomeric DNA binding(GO:0060380) positive regulation of single-stranded telomeric DNA binding(GO:0060381) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.0 | 0.5 | GO:0010369 | chromocenter(GO:0010369) |
| 0.0 | 0.4 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.1 | 0.3 | GO:1990037 | Lewy body core(GO:1990037) |
| 0.0 | 0.3 | GO:0070187 | telosome(GO:0070187) |
| 0.0 | 0.3 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.0 | 0.2 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.0 | 0.1 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.3 | GO:0003839 | gamma-glutamylcyclotransferase activity(GO:0003839) |
| 0.1 | 1.0 | GO:0004793 | glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 0.1 | 0.9 | GO:0015186 | L-glutamine transmembrane transporter activity(GO:0015186) |
| 0.1 | 0.6 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
| 0.2 | 0.5 | GO:0004611 | phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613) |
| 0.1 | 0.4 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.0 | 0.4 | GO:0017127 | cholesterol transporter activity(GO:0017127) |
| 0.1 | 0.3 | GO:0015375 | glycine:sodium symporter activity(GO:0015375) |
| 0.0 | 0.3 | GO:0052654 | branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656) |
| 0.0 | 0.3 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 0.9 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 0.4 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.0 | 0.4 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.0 | 0.3 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |