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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for ATF2_ATF1_ATF3
Z-value: 0.87
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Transcription factors associated with ATF2_ATF1_ATF3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ATF3 | hg19_v2_chr1_+_212738676_212738755 | -0.84 | 1.6e-01 | Click! |
| ATF2 | hg19_v2_chr2_-_176032843_176032941 | -0.81 | 1.9e-01 | Click! |
| ATF1 | hg19_v2_chr12_+_51158263_51158395 | -0.73 | 2.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_50979981 Show fit | 1.29 |
ENST00000595790.1
ENST00000600100.1 |
family with sequence similarity 71, member E1 |
|
| chr20_+_33146510 Show fit | 0.76 |
ENST00000397709.1
|
microtubule-associated protein 1 light chain 3 alpha |
|
| chr16_+_29911666 Show fit | 0.71 |
ENST00000563177.1
ENST00000483405.1 |
aspartate beta-hydroxylase domain containing 1 |
|
| chr22_+_24236191 Show fit | 0.66 |
ENST00000215754.7
|
macrophage migration inhibitory factor (glycosylation-inhibiting factor) |
|
| chr16_+_3068393 Show fit | 0.65 |
ENST00000573001.1
|
tumor necrosis factor receptor superfamily, member 12A |
|
| chr2_-_220408260 Show fit | 0.64 |
ENST00000373891.2
|
chondroitin polymerizing factor |
|
| chr19_-_51014345 Show fit | 0.62 |
ENST00000391815.3
ENST00000594350.1 ENST00000601423.1 |
Josephin domain containing 2 |
|
| chr19_-_51014460 Show fit | 0.62 |
ENST00000595669.1
|
Josephin domain containing 2 |
|
| chr2_-_220408430 Show fit | 0.60 |
ENST00000243776.6
|
chondroitin polymerizing factor |
|
| chr19_-_51014588 Show fit | 0.58 |
ENST00000598418.1
|
Josephin domain containing 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ATF2_ATF1_ATF3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | GO:0050650 | chondroitin sulfate proteoglycan biosynthetic process(GO:0050650) |
| 0.0 | 1.1 | GO:0031167 | rRNA methylation(GO:0031167) |
| 0.1 | 1.0 | GO:0007042 | lysosomal lumen acidification(GO:0007042) |
| 0.2 | 0.9 | GO:0045903 | positive regulation of translational fidelity(GO:0045903) |
| 0.1 | 0.8 | GO:0010040 | response to iron(II) ion(GO:0010040) |
| 0.1 | 0.7 | GO:0002906 | mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906) |
| 0.0 | 0.7 | GO:0060716 | labyrinthine layer blood vessel development(GO:0060716) |
| 0.1 | 0.6 | GO:1902269 | positive regulation of polyamine transmembrane transport(GO:1902269) |
| 0.1 | 0.6 | GO:2000323 | negative regulation of glucocorticoid receptor signaling pathway(GO:2000323) |
| 0.1 | 0.6 | GO:0006931 | substrate-dependent cell migration, cell attachment to substrate(GO:0006931) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 0.8 | GO:0044754 | autolysosome(GO:0044754) |
| 0.1 | 0.7 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 0.0 | 0.7 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 0.6 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.0 | 0.6 | GO:0016592 | mediator complex(GO:0016592) |
| 0.1 | 0.4 | GO:0071595 | Nem1-Spo7 phosphatase complex(GO:0071595) |
| 0.0 | 0.4 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
| 0.0 | 0.4 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 0.3 | GO:0035976 | AP1 complex(GO:0035976) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.2 | GO:0050510 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510) |
| 0.2 | 1.0 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |
| 0.1 | 0.9 | GO:1990932 | 5.8S rRNA binding(GO:1990932) |
| 0.0 | 0.8 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.1 | 0.7 | GO:0004167 | dopachrome isomerase activity(GO:0004167) |
| 0.0 | 0.7 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.1 | 0.6 | GO:0042978 | ornithine decarboxylase activator activity(GO:0042978) |
| 0.0 | 0.6 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.0 | 0.6 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.0 | 0.6 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 1.1 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 0.9 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 0.7 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 0.7 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.0 | 0.7 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.6 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.0 | 0.6 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 0.5 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 0.5 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |