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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for AIRE

Z-value: 0.48

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Transcription factors associated with AIRE

Gene Symbol Gene ID Gene Info
AIRE
ENSG00000160224.12 autoimmune regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
AIREhg19_v2_chr21_+_45705752_45705767-0.039.7e-01Click!

Activity profile of AIRE motif

Sorted Z-values of AIRE motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_-_56985873 0.28 ENST00000299721.3
CPLX4
complexin 4
chrX_-_139866723 0.26 ENST00000370532.2
CDR1
cerebellar degeneration-related protein 1, 34kDa
chr12_+_52643077 0.22 ENST00000553310.2
ENST00000544024.1
KRT86
keratin 86
chr19_-_52552051 0.21 ENST00000221315.5
ZNF432
zinc finger protein 432
chr6_-_33864684 0.21 ENST00000506222.2
ENST00000533304.1
LINC01016
long intergenic non-protein coding RNA 1016
chr5_+_667759 0.20 ENST00000594226.1
AC026740.1
Uncharacterized protein
chr14_-_75330537 0.17 ENST00000556084.2
ENST00000556489.2
ENST00000445876.1
PROX2
prospero homeobox 2
chr12_+_75874580 0.16 ENST00000456650.3
GLIPR1
GLI pathogenesis-related 1
chr19_-_52551814 0.16 ENST00000594154.1
ENST00000598745.1
ENST00000597273.1
ZNF432
zinc finger protein 432
chr2_+_38177575 0.16 ENST00000407257.1
ENST00000417700.2
ENST00000234195.3
ENST00000442857.1
RMDN2
regulator of microtubule dynamics 2
chr22_-_32767017 0.16 ENST00000400234.1
RFPL3S
RFPL3 antisense
chr7_-_64023441 0.15 ENST00000309683.6
ZNF680
zinc finger protein 680
chr19_-_23869970 0.14 ENST00000601010.1
ZNF675
zinc finger protein 675
chr18_-_37380230 0.13 ENST00000591629.1
LINC00669
long intergenic non-protein coding RNA 669
chr19_-_23869999 0.13 ENST00000601935.1
ENST00000359788.4
ENST00000600313.1
ENST00000596211.1
ENST00000599168.1
ZNF675
zinc finger protein 675
chr6_+_22221010 0.13 ENST00000567753.1
RP11-524C21.2
RP11-524C21.2
chr19_-_16606988 0.13 ENST00000269881.3
CALR3
calreticulin 3
chr15_-_52043722 0.13 ENST00000454181.2
LYSMD2
LysM, putative peptidoglycan-binding, domain containing 2
chr15_-_52043631 0.12 ENST00000558126.1
LYSMD2
LysM, putative peptidoglycan-binding, domain containing 2
chr15_+_27112948 0.11 ENST00000555060.1
GABRA5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr21_+_30502806 0.11 ENST00000399928.1
ENST00000399926.1
MAP3K7CL
MAP3K7 C-terminal like
chr1_+_165864821 0.11 ENST00000470820.1
UCK2
uridine-cytidine kinase 2
chr16_-_20566616 0.10 ENST00000569163.1
ACSM2B
acyl-CoA synthetase medium-chain family member 2B
chr16_+_75182376 0.10 ENST00000570010.1
ENST00000568079.1
ENST00000464850.1
ENST00000332307.4
ENST00000393430.2
ZFP1
ZFP1 zinc finger protein
chr4_-_88450612 0.10 ENST00000418378.1
ENST00000282470.6
SPARCL1
SPARC-like 1 (hevin)
chr10_+_90660832 0.10 ENST00000371924.1
STAMBPL1
STAM binding protein-like 1
chr22_+_42017987 0.09 ENST00000405506.1
XRCC6
X-ray repair complementing defective repair in Chinese hamster cells 6
chr6_-_31514333 0.09 ENST00000376151.4
ATP6V1G2
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr10_+_115511213 0.09 ENST00000361048.1
PLEKHS1
pleckstrin homology domain containing, family S member 1
chr19_-_48753028 0.08 ENST00000522431.1
CARD8
caspase recruitment domain family, member 8
chr9_+_42717234 0.08 ENST00000377590.1
FOXD4L2
forkhead box D4-like 2
chr2_+_62423242 0.08 ENST00000301998.4
B3GNT2
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
chr4_-_4544061 0.07 ENST00000507908.1
STX18
syntaxin 18
chr5_+_122181279 0.07 ENST00000395451.4
ENST00000506996.1
SNX24
sorting nexin 24
chr5_+_122181184 0.07 ENST00000513881.1
SNX24
sorting nexin 24
chr9_-_114361665 0.07 ENST00000309195.5
PTGR1
prostaglandin reductase 1
chr4_+_71587669 0.07 ENST00000381006.3
ENST00000226328.4
RUFY3
RUN and FYVE domain containing 3
chr2_+_172864490 0.07 ENST00000315796.4
METAP1D
methionyl aminopeptidase type 1D (mitochondrial)
chr12_+_20963647 0.07 ENST00000381545.3
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr4_-_104119528 0.07 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
CENPE
centromere protein E, 312kDa
chr9_-_70429731 0.07 ENST00000377413.1
FOXD4L4
forkhead box D4-like 4
chr15_-_38519066 0.07 ENST00000561320.1
ENST00000561161.1
RP11-346D14.1
RP11-346D14.1
chr9_-_70178815 0.06 ENST00000377420.1
FOXD4L5
forkhead box D4-like 5
chr15_+_85523671 0.06 ENST00000310298.4
ENST00000557957.1
PDE8A
phosphodiesterase 8A
chr3_+_140981456 0.06 ENST00000504264.1
ACPL2
acid phosphatase-like 2
chr14_+_39944025 0.06 ENST00000554328.1
ENST00000556620.1
ENST00000557197.1
RP11-111A21.1
RP11-111A21.1
chr10_+_127661942 0.06 ENST00000417114.1
ENST00000445510.1
ENST00000368691.1
FANK1
fibronectin type III and ankyrin repeat domains 1
chr10_-_69597810 0.06 ENST00000483798.2
DNAJC12
DnaJ (Hsp40) homolog, subfamily C, member 12
chr2_-_127977654 0.06 ENST00000409327.1
CYP27C1
cytochrome P450, family 27, subfamily C, polypeptide 1
chr12_+_4758264 0.06 ENST00000266544.5
NDUFA9
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
chr8_+_124780672 0.06 ENST00000521166.1
ENST00000334705.7
FAM91A1
family with sequence similarity 91, member A1
chr2_-_198540719 0.05 ENST00000295049.4
RFTN2
raftlin family member 2
chr1_+_174670143 0.05 ENST00000367687.1
ENST00000347255.2
RABGAP1L
RAB GTPase activating protein 1-like
chr9_-_104198042 0.05 ENST00000374855.4
ALDOB
aldolase B, fructose-bisphosphate
chr8_+_128748308 0.05 ENST00000377970.2
MYC
v-myc avian myelocytomatosis viral oncogene homolog
chr8_+_104384616 0.05 ENST00000520337.1
CTHRC1
collagen triple helix repeat containing 1
chr6_+_168434678 0.05 ENST00000496008.1
KIF25
kinesin family member 25
chr9_-_95298254 0.05 ENST00000444490.2
ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr5_+_118690466 0.05 ENST00000503646.1
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr15_+_52043758 0.05 ENST00000249700.4
ENST00000539962.2
TMOD2
tropomodulin 2 (neuronal)
chrX_-_102941596 0.05 ENST00000441076.2
ENST00000422355.1
ENST00000442614.1
ENST00000422154.2
ENST00000451301.1
MORF4L2
mortality factor 4 like 2
chr13_-_26795840 0.05 ENST00000381570.3
ENST00000399762.2
ENST00000346166.3
RNF6
ring finger protein (C3H2C3 type) 6
chr16_-_31147020 0.05 ENST00000568261.1
ENST00000567797.1
ENST00000317508.6
PRSS8
protease, serine, 8
chr6_-_106773610 0.05 ENST00000369076.3
ENST00000369070.1
ATG5
autophagy related 5
chr10_-_101841588 0.05 ENST00000370418.3
CPN1
carboxypeptidase N, polypeptide 1
chr12_+_10658489 0.05 ENST00000538173.1
EIF2S3L
Putative eukaryotic translation initiation factor 2 subunit 3-like protein
chr10_+_115511434 0.05 ENST00000369312.4
PLEKHS1
pleckstrin homology domain containing, family S member 1
chr2_+_179316163 0.05 ENST00000409117.3
DFNB59
deafness, autosomal recessive 59
chr12_+_75874984 0.05 ENST00000550491.1
GLIPR1
GLI pathogenesis-related 1
chr3_-_121468602 0.05 ENST00000340645.5
GOLGB1
golgin B1
chrM_+_12331 0.05 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH dehydrogenase 5
chr1_-_145826450 0.04 ENST00000462900.2
GPR89A
G protein-coupled receptor 89A
chr12_-_76462713 0.04 ENST00000552056.1
NAP1L1
nucleosome assembly protein 1-like 1
chr4_+_71588372 0.04 ENST00000536664.1
RUFY3
RUN and FYVE domain containing 3
chr7_-_64467031 0.04 ENST00000394323.2
ERV3-1
endogenous retrovirus group 3, member 1
chr1_+_36038971 0.04 ENST00000373235.3
TFAP2E
transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)
chr4_+_76649797 0.04 ENST00000538159.1
ENST00000514213.2
USO1
USO1 vesicle transport factor
chr14_-_55658252 0.04 ENST00000395425.2
DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chrM_+_5824 0.04 ENST00000361624.2
MT-CO1
mitochondrially encoded cytochrome c oxidase I
chr11_+_64794991 0.04 ENST00000352068.5
ENST00000525648.1
SNX15
sorting nexin 15
chr20_+_21284416 0.04 ENST00000539513.1
XRN2
5'-3' exoribonuclease 2
chr7_-_137028498 0.04 ENST00000393083.2
PTN
pleiotrophin
chr7_-_137028534 0.04 ENST00000348225.2
PTN
pleiotrophin
chr5_+_122181128 0.04 ENST00000261369.4
SNX24
sorting nexin 24
chr18_-_56985776 0.04 ENST00000587244.1
CPLX4
complexin 4
chr14_+_45605157 0.04 ENST00000542564.2
FANCM
Fanconi anemia, complementation group M
chr6_+_26104104 0.04 ENST00000377803.2
HIST1H4C
histone cluster 1, H4c
chr6_+_118869452 0.04 ENST00000357525.5
PLN
phospholamban
chr4_-_47465666 0.04 ENST00000381571.4
COMMD8
COMM domain containing 8
chr17_+_77030267 0.04 ENST00000581774.1
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr1_-_52344471 0.04 ENST00000352171.7
ENST00000354831.7
NRD1
nardilysin (N-arginine dibasic convertase)
chr12_+_75874460 0.03 ENST00000266659.3
GLIPR1
GLI pathogenesis-related 1
chr3_-_133648656 0.03 ENST00000408895.2
C3orf36
chromosome 3 open reading frame 36
chr9_-_25678856 0.03 ENST00000358022.3
TUSC1
tumor suppressor candidate 1
chr19_-_48752812 0.03 ENST00000359009.4
CARD8
caspase recruitment domain family, member 8
chr20_+_44036900 0.03 ENST00000443296.1
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr14_-_55658323 0.03 ENST00000554067.1
ENST00000247191.2
DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr9_-_114362093 0.03 ENST00000538962.1
ENST00000407693.2
ENST00000238248.3
PTGR1
prostaglandin reductase 1
chr17_+_3323862 0.03 ENST00000291231.1
OR3A3
olfactory receptor, family 3, subfamily A, member 3
chr3_-_121468513 0.03 ENST00000494517.1
ENST00000393667.3
GOLGB1
golgin B1
chr1_-_52344416 0.03 ENST00000544028.1
NRD1
nardilysin (N-arginine dibasic convertase)
chr8_-_141774467 0.03 ENST00000520151.1
ENST00000519024.1
ENST00000519465.1
PTK2
protein tyrosine kinase 2
chr2_-_136633940 0.03 ENST00000264156.2
MCM6
minichromosome maintenance complex component 6
chrX_-_139047669 0.03 ENST00000370540.1
CXorf66
chromosome X open reading frame 66
chr19_-_48753104 0.03 ENST00000447740.2
CARD8
caspase recruitment domain family, member 8
chr4_+_78829479 0.03 ENST00000504901.1
MRPL1
mitochondrial ribosomal protein L1
chr22_+_25202232 0.03 ENST00000400358.4
ENST00000400359.4
SGSM1
small G protein signaling modulator 1
chr6_+_26538566 0.03 ENST00000377575.2
HMGN4
high mobility group nucleosomal binding domain 4
chr1_+_47603109 0.03 ENST00000371890.3
ENST00000294337.3
ENST00000371891.3
CYP4A22
cytochrome P450, family 4, subfamily A, polypeptide 22
chr7_-_87936195 0.03 ENST00000414498.1
ENST00000301959.5
ENST00000380079.4
STEAP4
STEAP family member 4
chr14_-_65409438 0.03 ENST00000557049.1
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr17_+_41857793 0.03 ENST00000449302.3
C17orf105
chromosome 17 open reading frame 105
chr2_-_166810261 0.03 ENST00000243344.7
TTC21B
tetratricopeptide repeat domain 21B
chr16_-_89119355 0.03 ENST00000537498.1
CTD-2555A7.2
CTD-2555A7.2
chr22_+_40322623 0.03 ENST00000399090.2
GRAP2
GRB2-related adaptor protein 2
chr22_+_40322595 0.03 ENST00000420971.1
ENST00000544756.1
GRAP2
GRB2-related adaptor protein 2
chr1_-_154600421 0.02 ENST00000368471.3
ENST00000292205.5
ADAR
adenosine deaminase, RNA-specific
chr5_+_141488070 0.02 ENST00000253814.4
NDFIP1
Nedd4 family interacting protein 1
chr13_+_50570019 0.02 ENST00000442421.1
TRIM13
tripartite motif containing 13
chr12_-_64784471 0.02 ENST00000333722.5
C12orf56
chromosome 12 open reading frame 56
chr6_+_42584847 0.02 ENST00000372883.3
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr2_-_225811747 0.02 ENST00000409592.3
DOCK10
dedicator of cytokinesis 10
chr14_+_45605127 0.02 ENST00000556036.1
ENST00000267430.5
FANCM
Fanconi anemia, complementation group M
chr1_-_35497506 0.02 ENST00000317538.5
ENST00000373340.2
ENST00000357182.4
ZMYM6
zinc finger, MYM-type 6
chr6_+_116937636 0.02 ENST00000368581.4
ENST00000229554.5
ENST00000368580.4
RSPH4A
radial spoke head 4 homolog A (Chlamydomonas)
chr16_+_50059125 0.02 ENST00000427478.2
CNEP1R1
CTD nuclear envelope phosphatase 1 regulatory subunit 1
chr3_-_121264848 0.02 ENST00000264233.5
POLQ
polymerase (DNA directed), theta
chr2_-_202508169 0.02 ENST00000409883.2
TMEM237
transmembrane protein 237
chr4_-_114682719 0.02 ENST00000394522.3
CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chrM_+_14741 0.02 ENST00000361789.2
MT-CYB
mitochondrially encoded cytochrome b
chr11_-_119249805 0.02 ENST00000527843.1
USP2
ubiquitin specific peptidase 2
chr12_-_59175485 0.02 ENST00000550678.1
ENST00000552201.1
RP11-767I20.1
RP11-767I20.1
chr1_+_207669573 0.02 ENST00000400960.2
ENST00000534202.1
CR1
complement component (3b/4b) receptor 1 (Knops blood group)
chr1_+_207669613 0.02 ENST00000367049.4
ENST00000529814.1
CR1
complement component (3b/4b) receptor 1 (Knops blood group)
chr19_+_45417921 0.02 ENST00000252491.4
ENST00000592885.1
ENST00000589781.1
APOC1
apolipoprotein C-I
chr2_+_204732487 0.02 ENST00000302823.3
CTLA4
cytotoxic T-lymphocyte-associated protein 4
chr4_+_1385340 0.02 ENST00000324803.4
CRIPAK
cysteine-rich PAK1 inhibitor
chr4_-_66536057 0.02 ENST00000273854.3
EPHA5
EPH receptor A5
chr19_+_11708259 0.01 ENST00000587939.1
ENST00000588174.1
ZNF627
zinc finger protein 627
chr16_+_14802801 0.01 ENST00000526520.1
ENST00000531598.2
NPIPA3
nuclear pore complex interacting protein family, member A3
chr6_+_167525277 0.01 ENST00000400926.2
CCR6
chemokine (C-C motif) receptor 6
chrM_+_8366 0.01 ENST00000361851.1
MT-ATP8
mitochondrially encoded ATP synthase 8
chr12_-_50677255 0.01 ENST00000551691.1
ENST00000394943.3
ENST00000341247.4
LIMA1
LIM domain and actin binding 1
chr1_+_100810575 0.01 ENST00000542213.1
CDC14A
cell division cycle 14A
chr19_-_36304201 0.01 ENST00000301175.3
PRODH2
proline dehydrogenase (oxidase) 2
chr10_-_4720333 0.01 ENST00000430998.2
LINC00704
long intergenic non-protein coding RNA 704
chr9_-_113761720 0.01 ENST00000541779.1
ENST00000374430.2
LPAR1
lysophosphatidic acid receptor 1
chr13_+_111893533 0.01 ENST00000478679.1
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr6_-_149806105 0.01 ENST00000389942.5
ENST00000416573.2
ENST00000542614.1
ENST00000409806.3
ZC3H12D
zinc finger CCCH-type containing 12D
chr21_+_39644395 0.01 ENST00000398934.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr8_-_141728444 0.01 ENST00000521562.1
PTK2
protein tyrosine kinase 2
chr1_-_167883327 0.01 ENST00000476818.2
ENST00000367851.4
ENST00000367848.1
ADCY10
adenylate cyclase 10 (soluble)
chr21_+_39644214 0.01 ENST00000438657.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr1_-_52456352 0.01 ENST00000371655.3
RAB3B
RAB3B, member RAS oncogene family
chr9_+_71986182 0.01 ENST00000303068.7
FAM189A2
family with sequence similarity 189, member A2
chr3_+_189507460 0.01 ENST00000434928.1
TP63
tumor protein p63
chr21_+_39644172 0.00 ENST00000398932.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr20_+_44036620 0.00 ENST00000372710.3
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr4_-_66536196 0.00 ENST00000511294.1
EPHA5
EPH receptor A5
chr2_+_234686976 0.00 ENST00000389758.3
MROH2A
maestro heat-like repeat family member 2A
chr17_+_36452989 0.00 ENST00000312513.5
ENST00000582535.1
MRPL45
mitochondrial ribosomal protein L45
chr5_+_72143988 0.00 ENST00000506351.2
TNPO1
transportin 1
chr6_+_42141029 0.00 ENST00000372958.1
GUCA1A
guanylate cyclase activator 1A (retina)
chr4_-_17513851 0.00 ENST00000281243.5
QDPR
quinoid dihydropteridine reductase
chr21_+_39644305 0.00 ENST00000398930.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15

Network of associatons between targets according to the STRING database.

First level regulatory network of AIRE

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.0 0.3 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.0 0.1 GO:0009224 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
0.0 0.1 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.0 0.1 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.0 0.1 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.0 0.1 GO:0046603 negative regulation of mitotic centrosome separation(GO:0046603)
0.0 0.1 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 0.0 GO:0030070 insulin processing(GO:0030070)
0.0 0.1 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
0.0 0.1 GO:0097327 response to antineoplastic agent(GO:0097327)
0.0 0.1 GO:0090096 regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096)
0.0 0.0 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.0 0.0 GO:1902081 regulation of calcium ion import into sarcoplasmic reticulum(GO:1902080) negative regulation of calcium ion import into sarcoplasmic reticulum(GO:1902081)
0.0 0.0 GO:0030451 regulation of complement activation, alternative pathway(GO:0030451) negative regulation of complement activation, alternative pathway(GO:0045957) positive regulation of serine-type endopeptidase activity(GO:1900005) positive regulation of serine-type peptidase activity(GO:1902573)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0071821 FANCM-MHF complex(GO:0071821)
0.0 0.1 GO:0043564 Ku70:Ku80 complex(GO:0043564)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0032440 2-alkenal reductase [NAD(P)] activity(GO:0032440)
0.0 0.1 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.0 0.1 GO:0005502 11-cis retinal binding(GO:0005502) all-trans retinal binding(GO:0005503)
0.0 0.1 GO:0032089 NACHT domain binding(GO:0032089)
0.0 0.1 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.0 GO:0070052 collagen V binding(GO:0070052)
0.0 0.1 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0 0.0 GO:0001147 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.0 0.0 GO:0004877 complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877)
0.0 0.1 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)