ISMARA results: ACAUUCA

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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for ACAUUCA

Z-value: 2.19

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miRNA associated with seed ACAUUCA

Name	miRBASE accession
hsa-miR-181a-5p miRBase	MIMAT0000256
hsa-miR-181b-5p miRBase	MIMAT0000257
hsa-miR-181c-5p miRBase	MIMAT0000258
hsa-miR-181d-5p miRBase	MIMAT0002821
hsa-miR-4262 miRBase	MIMAT0016894

Activity profile of ACAUUCA motif

Sorted Z-values of ACAUUCA motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr22_+_33197683 Show fit	0.71	ENST00000266085.6	TIMP3 Ensembl NCBI GeneCards UniProt Show fit	TIMP metallopeptidase inhibitor 3
chr13_-_77601282 Show fit	0.65	ENST00000355619.5	FBXL3 Ensembl NCBI GeneCards UniProt Show fit	F-box and leucine-rich repeat protein 3
chr2_+_64681219 Show fit	0.64	ENST00000238875.5	LGALSL Ensembl NCBI GeneCards UniProt Show fit	lectin, galactoside-binding-like
chr4_+_39046615 Show fit	0.58	ENST00000261425.3 ENST00000508137.2	KLHL5 Ensembl NCBI GeneCards UniProt Show fit	kelch-like family member 5
chr8_-_67525473 Show fit	0.57	ENST00000522677.3	MYBL1 Ensembl NCBI GeneCards UniProt Show fit	v-myb avian myeloblastosis viral oncogene homolog-like 1
chrX_-_77395186 Show fit	0.57	ENST00000341864.5	TAF9B Ensembl NCBI GeneCards UniProt Show fit	TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
chr12_-_76953284 Show fit	0.57	ENST00000547544.1 ENST00000393249.2	OSBPL8 Ensembl NCBI GeneCards UniProt Show fit	oxysterol binding protein-like 8
chr1_+_40627038 Show fit	0.56	ENST00000372771.4	RLF Ensembl NCBI GeneCards UniProt Show fit	rearranged L-myc fusion
chr1_-_85156216 Show fit	0.56	ENST00000342203.3 ENST00000370612.4	SSX2IP Ensembl NCBI GeneCards UniProt Show fit	synovial sarcoma, X breakpoint 2 interacting protein
chr9_-_128003606 Show fit	0.55	ENST00000324460.6	HSPA5 Ensembl NCBI GeneCards UniProt Show fit	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ACAUUCA

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.0	GO:0043153	entrainment of circadian clock by photoperiod(GO:0043153)
0.2	0.7	GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.0	0.7	GO:0030033	microvillus assembly(GO:0030033)
0.2	0.6	GO:0021577	hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.0	0.6	GO:0090204	protein localization to nuclear pore(GO:0090204)
0.0	0.6	GO:1904153	negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0	0.6	GO:0015074	DNA integration(GO:0015074)
0.0	0.6	GO:0042711	maternal behavior(GO:0042711) parental behavior(GO:0060746)
0.0	0.6	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.0	0.6	GO:1900739	regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)

Showing 1 to 10 of 202 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.3	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.0	1.2	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.1	0.9	GO:0031089	platelet dense granule lumen(GO:0031089)
0.0	0.7	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	0.7	GO:1990752	microtubule end(GO:1990752)
0.0	0.6	GO:0000124	SAGA complex(GO:0000124)
0.0	0.6	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.6	GO:0034451	centriolar satellite(GO:0034451)
0.0	0.5	GO:0032433	filopodium tip(GO:0032433)
0.0	0.5	GO:0031209	SCAR complex(GO:0031209)

Showing 1 to 10 of 68 entries

Gene overrepresentation in molecular_function category:

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Total log-likelihood	Term	Description
1.1	GO:0048365	Rac GTPase binding(GO:0048365)
0.9	GO:0015035	protein disulfide oxidoreductase activity(GO:0015035)
0.9	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.9	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)
0.9	GO:0015485	cholesterol binding(GO:0015485)
0.9	GO:0019003	GDP binding(GO:0019003)
0.8	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.8	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.8	GO:0008235	metalloexopeptidase activity(GO:0008235)
0.7	GO:0001135	transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)

Showing 1 to 10 of 121 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
1.8	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.9	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.8	PID RAS PATHWAY	Regulation of Ras family activation
0.7	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.6	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.6	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.5	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.5	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.4	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.3	ST JAK STAT PATHWAY	Jak-STAT Pathway

Showing 1 to 10 of 13 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.3	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0	0.8	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.6	REACTOME RAF MAP KINASE CASCADE	Genes involved in RAF/MAP kinase cascade
0.0	0.6	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	0.6	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.6	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0	0.5	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.0	0.5	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.0	0.4	REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0	0.4	REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	Genes involved in Thromboxane signalling through TP receptor

Showing 1 to 10 of 25 entries

Results for ACAUUCA

Z-value: 2.19

Motif logo

miRNA associated with seed ACAUUCA

Activity profile of ACAUUCA motif

Sorted Z-values of ACAUUCA motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ACAUUCA

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: