Motif ID: bHLH_family.p2

Z-value: 2.081


Transcription factors associated with bHLH_family.p2:

Gene SymbolEntrez IDGene Name
ARNTL 406 aryl hydrocarbon receptor nuclear translocator-like
ARNTL2 56938 aryl hydrocarbon receptor nuclear translocator-like 2
CLOCK 9575 clock homolog (mouse)
HES6 55502 hairy and enhancer of split 6 (Drosophila)
HEY1 23462 hairy/enhancer-of-split related with YRPW motif 1
HEY2 23493 hairy/enhancer-of-split related with YRPW motif 2
HEYL 26508 hairy/enhancer-of-split related with YRPW motif-like
ID1 3397 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
MITF 4286 microphthalmia-associated transcription factor
MLXIPL 51085 MLX interacting protein-like
MNT 4335 MAX binding protein
MXD3 83463 MAX dimerization protein 3
MXD4 10608 MAX dimerization protein 4
MXI1 4601 MAX interactor 1
NPAS2 4862 neuronal PAS domain protein 2
OLIG1 116448 oligodendrocyte transcription factor 1
OLIG2 10215 oligodendrocyte lineage transcription factor 2
TFE3 7030 transcription factor binding to IGHM enhancer 3



Activity profile for motif bHLH_family.p2.

activity profile for motif bHLH_family.p2


Sorted Z-values histogram for motif bHLH_family.p2

Sorted Z-values for motif bHLH_family.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of bHLH_family.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr22_+_38720881 6.544 NM_138435
FAM83F
family with sequence similarity 83, member F
chr1_+_148521852 3.508 NM_144697
C1orf51
chromosome 1 open reading frame 51
chr15_-_81113676 3.483 NM_030594
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr8_+_120289735 3.425 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr2_+_176680251 2.825 NM_021192
HOXD11
homeobox D11
chr13_+_32488477 2.759 NM_004795
KL
klotho
chrX_-_107866262 2.655 NM_003604
IRS4
insulin receptor substrate 4
chr2_+_74594093 2.649 TLX2
T-cell leukemia homeobox 2
chr5_-_132976121 2.596 NM_015082
FSTL4
follistatin-like 4
chr1_+_237616457 2.595 CHRM3
cholinergic receptor, muscarinic 3
chr5_+_132176921 2.578 NM_175873
ANKRD43
ankyrin repeat domain 43
chr2_-_172675480 2.559 NM_004405
DLX2
distal-less homeobox 2
chr17_-_37586716 2.452 NM_012285
KCNH4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr8_+_85258257 2.349 RALYL
RALY RNA binding protein-like
chr17_-_29930431 2.274 NM_207454
C17orf102
chromosome 17 open reading frame 102
chr1_-_92721633 2.231 GFI1
growth factor independent 1 transcription repressor
chrX_-_131919896 2.194 HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr11_+_45900731 2.109 GYLTL1B
glycosyltransferase-like 1B
chr11_-_61441536 2.104 NM_013401
RAB3IL1
RAB3A interacting protein (rabin3)-like 1
chr1_-_92721943 2.084 NM_001127215
GFI1
growth factor independent 1 transcription repressor

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 40 entries
Enrichment   P-value GO Accession GO Term
46.95 1.99e-02 GO:0060678 dichotomous subdivision of terminal units involved in ureteric bud branching
41.74 2.97e-02 GO:0048880 sensory system development
41.74 2.97e-02 GO:0048892 lateral line nerve development
41.74 2.97e-02 GO:0048895 lateral line nerve glial cell differentiation
41.74 2.97e-02 GO:0048925 lateral line system development
41.74 2.97e-02 GO:0048937 lateral line nerve glial cell development
41.74 2.97e-02 GO:0050935 iridophore differentiation
33.39 3.64e-03 GO:0048484 enteric nervous system development
18.55 4.35e-02 GO:0048483 autonomic nervous system development
13.92 2.09e-02 GO:0007422 peripheral nervous system development
13.32 2.60e-02 GO:0001649 osteoblast differentiation
7.19 4.06e-02 GO:0001763 morphogenesis of a branching structure
5.55 1.75e-04 GO:0007389 pattern specification process
4.68 1.83e-02 GO:0001501 skeletal system development
3.46 2.19e-02 GO:0010629 negative regulation of gene expression
3.35 3.18e-02 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
3.27 2.28e-02 GO:0031327 negative regulation of cellular biosynthetic process
3.21 2.93e-02 GO:0009890 negative regulation of biosynthetic process
3.20 3.04e-02 GO:0030182 neuron differentiation
2.91 2.05e-02 GO:0010605 negative regulation of macromolecule metabolic process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
Enrichment   P-value GO Accession GO Term
4.06 7.31e-06 GO:0043565 sequence-specific DNA binding
3.35 1.42e-05 GO:0001071 nucleic acid binding transcription factor activity
3.35 1.42e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
3.16 7.97e-05 GO:0030528 transcription regulator activity
2.01 5.47e-03 GO:0003677 DNA binding
1.74 1.82e-02 GO:0003676 nucleic acid binding