Motif ID: ZIC1..3.p2

Z-value: 2.847


Transcription factors associated with ZIC1..3.p2:

Gene SymbolEntrez IDGene Name
ZIC1 7545 Zic family member 1 (odd-paired homolog, Drosophila)
ZIC2 7546 Zic family member 2 (odd-paired homolog, Drosophila)
ZIC3 7547 Zic family member 3 (odd-paired homolog, Drosophila)



Activity profile for motif ZIC1..3.p2.

activity profile for motif ZIC1..3.p2


Sorted Z-values histogram for motif ZIC1..3.p2

Sorted Z-values for motif ZIC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZIC1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_28306633 6.123 FOXG1
forkhead box G1
chr4_-_174687104 4.710 HAND2
heart and neural crest derivatives expressed 2
chrX_-_107866262 4.583 NM_003604
 IRS4
insulin receptor substrate 4
chr14_-_103058568 4.204 CKB
creatine kinase, brain
chr1_-_38285033 3.620 NM_002699
 POU3F1
POU class 3 homeobox 1
chr4_-_174686918 3.275 HAND2
heart and neural crest derivatives expressed 2
chr11_-_75056761 3.096 MAP6
microtubule-associated protein 6
chr10_-_95350949 3.074 NM_006744
 RBP4
retinol binding protein 4, plasma
chr12_-_42231990 2.950 NM_025003
 ADAMTS20
ADAM metallopeptidase with thrombospondin type 1 motif, 20
chr13_-_52320774 2.873 NM_002590
NM_032949
 PCDH8

protocadherin 8

chr16_-_47872880 2.795


chr9_+_99656013 2.776


chr19_+_10404110 2.657 NM_001111309
 PDE4A
phosphodiesterase 4A, cAMP-specific
chr8_+_1937711 2.577 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr14_+_100362236 2.572 MEG3
maternally expressed 3 (non-protein coding)
chr14_-_103058865 2.560 NM_001823
 CKB
creatine kinase, brain
chr11_-_75057062 2.552 NM_033063
NM_207577
 MAP6

microtubule-associated protein 6

chr14_+_100362204 2.543 MEG3
maternally expressed 3 (non-protein coding)
chr9_+_78824390 2.535 NM_001013735
 FOXB2
forkhead box B2
chr16_-_47872973 2.376 CBLN1
cerebellin 1 precursor

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 91 entries
Enrichment   P-value GO Accession GO Term
47.70 2.33e-02 GO:0021854 hypothalamus development
47.70 2.33e-02 GO:0042693 muscle cell fate commitment
27.83 1.01e-02 GO:0021846 cell proliferation in forebrain
25.30 1.23e-03 GO:0022029 telencephalon cell migration
24.20 1.56e-03 GO:0021885 forebrain cell migration
23.43 2.10e-02 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway
20.61 3.63e-03 GO:0009954 proximal/distal pattern formation
18.55 7.16e-04 GO:0021536 diencephalon development
18.55 6.27e-03 GO:0008589 regulation of smoothened signaling pathway
15.18 2.44e-03 GO:0001756 somitogenesis
14.21 3.64e-03 GO:0061053 somite development
13.92 4.13e-03 GO:0019228 regulation of action potential in neuron
13.92 2.69e-02 GO:0001656 metanephros development
13.92 2.69e-02 GO:0021761 limbic system development
13.58 3.05e-02 GO:0007272 ensheathment of neurons
13.58 3.05e-02 GO:0008366 axon ensheathment
10.60 2.04e-02 GO:0001508 regulation of action potential
10.28 2.45e-02 GO:0035282 segmentation
9.54 3.75e-02 GO:0048762 mesenchymal cell differentiation
8.77 2.95e-06 GO:0030900 forebrain development

Gene overrepresentation in compartment category:

Showing 1 to 5 of 5 entries
Enrichment   P-value GO Accession GO Term
5.06 1.43e-03 GO:0005667 transcription factor complex
4.03 1.26e-03 GO:0045202 synapse
3.88 3.23e-02 GO:0044456 synapse part
1.59 1.50e-02 GO:0005886 plasma membrane
1.57 2.23e-02 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 15 of 15 entries
Enrichment   P-value GO Accession GO Term
10.12 2.36e-02 GO:0008301 DNA bending activity
9.28 1.86e-03 GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
8.38 3.63e-03 GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
8.04 4.78e-03 GO:0016566 specific transcriptional repressor activity
7.42 2.83e-02 GO:0003704 specific RNA polymerase II transcription factor activity
5.17 1.16e-02 GO:0010843 promoter binding
5.03 1.44e-04 GO:0016563 transcription activator activity
4.96 1.58e-02 GO:0000975 regulatory region DNA binding
4.96 1.58e-02 GO:0001067 regulatory region nucleic acid binding
4.96 1.58e-02 GO:0044212 transcription regulatory region DNA binding
4.46 3.08e-03 GO:0016564 transcription repressor activity
4.30 1.25e-07 GO:0043565 sequence-specific DNA binding
3.81 7.78e-09 GO:0001071 nucleic acid binding transcription factor activity
3.81 7.78e-09 GO:0003700 sequence-specific DNA binding transcription factor activity
3.39 1.09e-06 GO:0030528 transcription regulator activity