Motif ID: KLF12.p2

Z-value: 3.030


Transcription factors associated with KLF12.p2:

Gene SymbolEntrez IDGene Name
KLF12 11278 Kruppel-like factor 12



Activity profile for motif KLF12.p2.

activity profile for motif KLF12.p2


Sorted Z-values histogram for motif KLF12.p2

Sorted Z-values for motif KLF12.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF12.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_27180398 2.649 NM_018951
 HOXA10
homeobox A10
chr10_+_94439658 2.553 NM_002729
 HHEX
hematopoietically expressed homeobox
chr2_+_176702667 2.378 NM_019558
 HOXD8
homeobox D8
chr3_-_193609531 2.220 NM_021032
 FGF12
fibroblast growth factor 12
chr13_-_27967215 2.204 NM_001159920
NM_001160030
NM_001160031
NM_002019
 FLT1



fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)



chrX_+_67965517 2.182 NM_004429
 EFNB1
ephrin-B1
chr3_-_173648896 2.097 NM_004122
NM_198407
 GHSR

growth hormone secretagogue receptor

chr10_+_106390848 2.084 NM_014978
 SORCS3
sortilin-related VPS10 domain containing receptor 3
chr1_-_90955365 1.934 NM_020063
 BARHL2
BarH-like homeobox 2
chrX_-_71268475 1.862 NM_001024455
 RGAG4
retrotransposon gag domain containing 4
chrX_-_111953009 1.838 NM_001113490
 AMOT
angiomotin
chr17_+_23723220 1.834 SARM1
sterile alpha and TIR motif containing 1
chr1_+_63561632 1.829 FOXD3
forkhead box D3
chr12_+_79625538 1.772 NM_002469
 MYF6
myogenic factor 6 (herculin)
chr1_+_152741318 1.730 NM_001098475
NM_182499
 TDRD10

tudor domain containing 10

chr16_-_47873183 1.724 NM_004352
 CBLN1
cerebellin 1 precursor
chr12_+_52665196 1.622 NM_017409
 HOXC10
homeobox C10
chr1_+_16247870 1.622 NM_001165945
 CLCNKB
chloride channel Kb
chr8_-_140784416 1.599 NM_016601
 KCNK9
potassium channel, subfamily K, member 9
chr6_-_33268177 1.590 NM_001163771
NM_080679
NM_080680
NM_080681
 COL11A2



collagen, type XI, alpha 2




Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 18 of 18 entries
Enrichment   P-value GO Accession GO Term
191.30 1.59e-02 GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
191.30 1.59e-02 GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
127.54 4.74e-02 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
127.54 4.74e-02 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
127.54 4.74e-02 GO:0070296 sarcoplasmic reticulum calcium ion transport
11.15 9.06e-03 GO:0061138 morphogenesis of a branching epithelium
9.42 2.37e-02 GO:0001763 morphogenesis of a branching structure
8.71 8.73e-03 GO:0009952 anterior/posterior pattern formation
7.88 4.76e-06 GO:0007389 pattern specification process
5.85 1.25e-02 GO:0001501 skeletal system development
5.20 1.02e-05 GO:0009790 embryo development
3.63 2.89e-02 GO:0007267 cell-cell signaling
3.15 3.62e-02 GO:0007154 cell communication
2.41 3.15e-04 GO:0048731 system development
2.17 9.16e-04 GO:0007275 multicellular organismal development
2.17 3.53e-03 GO:0048856 anatomical structure development
1.98 8.34e-03 GO:0032502 developmental process
1.83 1.55e-03 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

Showing 1 to 1 of 1 entries
Enrichment   P-value GO Accession GO Term
27.34 1.96e-02 GO:0033017 sarcoplasmic reticulum membrane

Gene overrepresentation in function category:

Showing 1 to 5 of 5 entries
Enrichment   P-value GO Accession GO Term
76.53 2.88e-02 GO:0005219 ryanodine-sensitive calcium-release channel activity
4.14 5.80e-04 GO:0043565 sequence-specific DNA binding
3.02 1.06e-02 GO:0030528 transcription regulator activity
2.88 3.12e-02 GO:0001071 nucleic acid binding transcription factor activity
2.88 3.12e-02 GO:0003700 sequence-specific DNA binding transcription factor activity