Motif ID: HIC1.p2

Z-value: 4.741


Transcription factors associated with HIC1.p2:

Gene SymbolEntrez IDGene Name
HIC1 3090 hypermethylated in cancer 1



Activity profile for motif HIC1.p2.

activity profile for motif HIC1.p2


Sorted Z-values histogram for motif HIC1.p2

Sorted Z-values for motif HIC1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_1704661 8.285 NM_001080488
 ONECUT3
one cut homeobox 3
chr9_+_94987032 8.071 NM_006648
 WNK2
WNK lysine deficient protein kinase 2
chr12_-_131415854 7.967 NM_001122636
 GALNT9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)
chr5_+_76542461 6.954 NM_001029851
NM_001029852
NM_001029853
NM_001029854
NM_003719
 PDE8B




phosphodiesterase 8B




chr18_+_74841262 6.765 NM_171999
 SALL3
sal-like 3 (Drosophila)
chr16_+_162845 6.440 NM_000517
 HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr18_-_68361742 6.277 CBLN2
cerebellin 2 precursor
chr2_-_233501069 6.053 NM_001114090
 NGEF
neuronal guanine nucleotide exchange factor
chr19_+_659766 5.649 NM_001040134
NM_002579
 PALM

paralemmin

chr7_+_154943466 5.640 NM_001427
 EN2
engrailed homeobox 2
chr11_+_359723 5.600 NM_178537
 B4GALNT4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr10_-_103525646 5.418 NM_006119
NM_033163
NM_033164
NM_033165
 FGF8



fibroblast growth factor 8 (androgen-induced)



chr15_-_27650218 5.358 NM_015307
 FAM189A1
family with sequence similarity 189, member A1
chr15_-_49174107 5.298 TNFAIP8L3
tumor necrosis factor, alpha-induced protein 8-like 3
chr7_-_44331544 5.243 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
 CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr22_+_47263919 5.230 NM_001082967
 FAM19A5
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
chr8_+_1937711 5.118 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr4_-_41848874 4.992 BEND4
BEN domain containing 4
chr4_+_3737872 4.953 ADRA2C
adrenergic, alpha-2C-, receptor
chr4_-_174687104 4.892 HAND2
heart and neural crest derivatives expressed 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 143 entries
Enrichment   P-value GO Accession GO Term
11.53 1.18e-02 GO:0035412 regulation of catenin import into nucleus
10.85 1.77e-02 GO:0021772 olfactory bulb development
10.85 1.77e-02 GO:0021988 olfactory lobe development
10.76 3.36e-03 GO:0046058 cAMP metabolic process
8.45 6.57e-05 GO:0007189 activation of adenylate cyclase activity by G-protein signaling pathway
8.45 6.57e-05 GO:0009187 cyclic nucleotide metabolic process
8.45 6.57e-05 GO:0010578 regulation of adenylate cyclase activity involved in G-protein signaling pathway
8.45 6.57e-05 GO:0010579 positive regulation of adenylate cyclase activity by G-protein signaling pathway
7.09 1.35e-04 GO:0007190 activation of adenylate cyclase activity
6.96 1.69e-04 GO:0031281 positive regulation of cyclase activity
6.96 1.69e-04 GO:0045762 positive regulation of adenylate cyclase activity
6.71 2.62e-04 GO:0051349 positive regulation of lyase activity
5.93 3.17e-03 GO:0007194 negative regulation of adenylate cyclase activity
5.93 3.17e-03 GO:0031280 negative regulation of cyclase activity
5.93 3.17e-03 GO:0051350 negative regulation of lyase activity
5.76 2.86e-06 GO:0045761 regulation of adenylate cyclase activity
5.65 4.05e-06 GO:0031279 regulation of cyclase activity
5.53 5.68e-06 GO:0051339 regulation of lyase activity
5.22 5.87e-06 GO:0030814 regulation of cAMP metabolic process
5.02 1.77e-04 GO:0007188 G-protein signaling, coupled to cAMP nucleotide second messenger

Gene overrepresentation in compartment category:

Showing 1 to 19 of 19 entries
Enrichment   P-value GO Accession GO Term
4.95 1.71e-04 GO:0008076 voltage-gated potassium channel complex
4.95 1.71e-04 GO:0034705 potassium channel complex
4.10 8.78e-05 GO:0034703 cation channel complex
3.10 9.22e-08 GO:0045202 synapse
3.10 1.01e-03 GO:0034702 ion channel complex
2.95 1.51e-02 GO:0030424 axon
2.79 5.95e-04 GO:0044456 synapse part
2.64 9.25e-05 GO:0043005 neuron projection
1.95 2.62e-02 GO:0030054 cell junction
1.86 8.87e-05 GO:0005887 integral to plasma membrane
1.85 8.63e-05 GO:0031226 intrinsic to plasma membrane
1.84 7.25e-03 GO:0042995 cell projection
1.73 4.55e-07 GO:0044459 plasma membrane part
1.54 6.83e-09 GO:0005886 plasma membrane
1.52 2.52e-08 GO:0071944 cell periphery
1.32 1.66e-04 GO:0031224 intrinsic to membrane
1.31 1.43e-05 GO:0044425 membrane part
1.31 7.92e-04 GO:0016021 integral to membrane
1.27 8.95e-06 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 20 of 35 entries
Enrichment   P-value GO Accession GO Term
20.49 6.13e-03 GO:0008504 monoamine transmembrane transporter activity
11.53 2.73e-03 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
10.85 4.11e-03 GO:0030552 cAMP binding
8.97 3.11e-03 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
8.78 1.61e-02 GO:0017147 Wnt-protein binding
8.61 4.20e-03 GO:0004112 cyclic-nucleotide phosphodiesterase activity
7.97 7.33e-03 GO:0016849 phosphorus-oxygen lyase activity
7.97 7.33e-03 GO:0030551 cyclic nucleotide binding
7.68 9.50e-03 GO:0009975 cyclase activity
7.68 3.68e-02 GO:0016208 AMP binding
6.94 1.94e-02 GO:0008376 acetylgalactosaminyltransferase activity
6.65 7.86e-03 GO:0008227 G-protein coupled amine receptor activity
4.59 2.26e-02 GO:0030165 PDZ domain binding
3.97 1.87e-02 GO:0015081 sodium ion transmembrane transporter activity
3.90 3.37e-04 GO:0022843 voltage-gated cation channel activity
3.76 3.14e-02 GO:0005249 voltage-gated potassium channel activity
3.66 5.90e-03 GO:0005267 potassium channel activity
3.62 7.93e-05 GO:0005244 voltage-gated ion channel activity
3.62 7.93e-05 GO:0022832 voltage-gated channel activity
2.91 7.49e-04 GO:0005261 cation channel activity