Motif ID: HBP1_HMGB_SSRP1_UBTF.p2

Z-value: 2.163


Transcription factors associated with HBP1_HMGB_SSRP1_UBTF.p2:

Gene SymbolEntrez IDGene Name
HBP1 26959 HMG-box transcription factor 1
HMGB2 3148 high-mobility group box 2
HMGB3 3149 high-mobility group box 3
SSRP1 6749 structure specific recognition protein 1
UBTF 7343 upstream binding transcription factor, RNA polymerase I



Activity profile for motif HBP1_HMGB_SSRP1_UBTF.p2.

activity profile for motif HBP1_HMGB_SSRP1_UBTF.p2


Sorted Z-values histogram for motif HBP1_HMGB_SSRP1_UBTF.p2

Sorted Z-values for motif HBP1_HMGB_SSRP1_UBTF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HBP1_HMGB_SSRP1_UBTF.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_105511615 7.332 NM_001004317
 LIN28B
lin-28 homolog B (C. elegans)
chr12_-_16649211 6.176 LMO3
LIM domain only 3 (rhombotin-like 2)
chr13_-_52320774 5.643 NM_002590
NM_032949
 PCDH8

protocadherin 8

chr14_-_56342097 5.512 NM_172337
 OTX2
orthodenticle homeobox 2
chr8_-_72436519 5.095 EYA1
eyes absent homolog 1 (Drosophila)
chr5_+_170668892 4.785 NM_021025
 TLX3
T-cell leukemia homeobox 3
chr11_-_16380967 4.585 NM_001145819
NM_017508
 SOX6

SRY (sex determining region Y)-box 6

chr5_-_88004891 4.225 LOC645323
hypothetical LOC645323
chr2_-_200033445 4.082 SATB2
SATB homeobox 2
chr14_+_36196523 4.005 NM_006194
 PAX9
paired box 9
chr18_+_3441589 3.632 NM_170695
NM_173210
 TGIF1

TGFB-induced factor homeobox 1

chr4_-_101658094 3.563 NM_001159694
NM_016242
 EMCN

endomucin

chr13_+_99431417 3.525


chr5_-_44424423 3.514 NM_004465
 FGF10
fibroblast growth factor 10
chr9_-_23816062 3.374 NM_004432
 ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr15_-_48198697 3.170 NM_024837
 ATP8B4
ATPase, class I, type 8B, member 4
chr2_+_12775814 3.000


chr18_-_28606839 2.923 NM_020805
 KLHL14
kelch-like 14 (Drosophila)
chr1_-_102234959 2.798 OLFM3
olfactomedin 3
chr8_-_72437020 2.707 NM_000503
 EYA1
eyes absent homolog 1 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 125 entries
Enrichment   P-value GO Accession GO Term
81.34 2.90e-03 GO:0010837 regulation of keratinocyte proliferation
40.67 3.95e-02 GO:0060638 mesenchymal-epithelial cell signaling
28.92 8.33e-03 GO:0060441 epithelial tube branching involved in lung morphogenesis
28.92 8.33e-03 GO:0060445 branching involved in salivary gland morphogenesis
28.54 6.22e-04 GO:0040036 regulation of fibroblast growth factor receptor signaling pathway
27.12 6.23e-05 GO:0021983 pituitary gland development
27.12 1.10e-02 GO:0021879 forebrain neuron differentiation
21.69 2.85e-02 GO:0060425 lung morphogenesis
21.09 3.14e-05 GO:0021536 diencephalon development
20.66 3.50e-02 GO:0021872 forebrain generation of neurons
20.66 3.50e-02 GO:0060603 mammary gland duct morphogenesis
20.09 4.07e-03 GO:0048286 lung alveolus development
19.72 4.24e-02 GO:0008038 neuron recognition
15.07 1.78e-02 GO:0061180 mammary gland epithelium development
14.79 2.80e-03 GO:0048663 neuron fate commitment
12.33 4.82e-02 GO:0009880 embryonic pattern specification
11.68 2.09e-03 GO:0042472 inner ear morphogenesis
9.86 6.60e-03 GO:0021953 central nervous system neuron differentiation
9.86 6.60e-03 GO:0042471 ear morphogenesis
9.72 3.33e-02 GO:0009953 dorsal/ventral pattern formation

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Showing 1 to 17 of 17 entries
Enrichment   P-value GO Accession GO Term
12.06 2.87e-04 GO:0004714 transmembrane receptor protein tyrosine kinase activity
9.38 1.57e-03 GO:0019199 transmembrane receptor protein kinase activity
6.78 1.29e-02 GO:0008201 heparin binding
5.87 1.12e-02 GO:0005539 glycosaminoglycan binding
5.59 4.33e-02 GO:0004713 protein tyrosine kinase activity
5.43 1.93e-02 GO:0001871 pattern binding
5.43 1.93e-02 GO:0030247 polysaccharide binding
5.37 2.95e-03 GO:0000975 regulatory region DNA binding
5.37 2.95e-03 GO:0001067 regulatory region nucleic acid binding
5.37 2.95e-03 GO:0044212 transcription regulatory region DNA binding
4.52 7.04e-09 GO:0043565 sequence-specific DNA binding
3.83 3.07e-09 GO:0001071 nucleic acid binding transcription factor activity
3.83 3.07e-09 GO:0003700 sequence-specific DNA binding transcription factor activity
2.85 3.36e-04 GO:0030528 transcription regulator activity
2.14 1.24e-04 GO:0003677 DNA binding
1.79 1.95e-03 GO:0003676 nucleic acid binding
1.21 1.80e-02 GO:0005488 binding