Motif ID: EWSR1-FLI1.p2

Z-value: 1.311


Transcription factors associated with EWSR1-FLI1.p2:

fusion protein between EWSR1 and FLI1 in an oncogenic event

Gene SymbolEntrez IDGene Name
EWSR1 2130 Ewing sarcoma breakpoint region 1
FLI1 2313 Friend leukemia virus integration 1



Activity profile for motif EWSR1-FLI1.p2.

activity profile for motif EWSR1-FLI1.p2


Sorted Z-values histogram for motif EWSR1-FLI1.p2

Sorted Z-values for motif EWSR1-FLI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EWSR1-FLI1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_120029426 2.588 NM_001128933
NM_001128934
NM_133477
 SYNPO2


synaptopodin 2


chr17_-_31146660 2.215 NM_001032278
NM_024302
 MMP28

matrix metallopeptidase 28

chr14_-_53493198 2.126 NM_001202
NM_130850
 BMP4

bone morphogenetic protein 4

chr6_-_10520592 1.954 NM_001032280
 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr4_-_86106567 1.953 NM_014991
 WDFY3
WD repeat and FYVE domain containing 3
chrX_+_1361570 1.900 NM_001161530
NM_172247
 CSF2RA

colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)

chr11_+_101485946 1.855 NM_001130145
NM_001195044
NM_006106
 YAP1


Yes-associated protein 1


chr1_-_223907283 1.796 NM_001008493
NM_018212
 ENAH

enabled homolog (Drosophila)

chr6_-_10520264 1.781 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr2_+_65069081 1.702 NM_001193493
 SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr2_+_113533155 1.656 NM_012275
 IL1F5
interleukin 1 family, member 5 (delta)
chr2_+_113532685 1.631 NM_173170
 IL1F5
interleukin 1 family, member 5 (delta)
chr1_-_68470585 1.481 NM_001002292
NM_001193334
NM_024911
 WLS


wntless homolog (Drosophila)


chr1_-_68071635 1.422 NM_018841
 GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr2_+_37425240 1.398 NM_012413
 QPCT
glutaminyl-peptide cyclotransferase
chr1_-_6468600 1.192 NM_001042665
 PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr4_+_183302105 1.178 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr1_-_93030538 1.162 NM_005665
 EVI5
ecotropic viral integration site 5
chr19_-_1966628 1.159 NM_017797
 BTBD2
BTB (POZ) domain containing 2
chr6_-_132314004 1.113 NM_001901
 CTGF
connective tissue growth factor

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 11 of 11 entries
Enrichment   P-value GO Accession GO Term
110.59 4.49e-02 GO:0010714 positive regulation of collagen metabolic process
110.59 4.49e-02 GO:0032967 positive regulation of collagen biosynthetic process
46.81 1.07e-02 GO:0001843 neural tube closure
45.64 1.16e-02 GO:0060606 tube closure
44.53 1.25e-02 GO:0014020 primary neural tube formation
37.26 2.13e-02 GO:0001841 neural tube formation
30.95 3.73e-02 GO:0001838 embryonic epithelial tube formation
30.44 2.52e-03 GO:0021915 neural tube development
30.44 3.92e-02 GO:0072175 epithelial tube formation
28.99 4.53e-02 GO:0035148 tube formation
11.77 1.67e-02 GO:0035295 tube development

Nothing significant found in compartment category.

Nothing significant found in function category.