Motif ID: EGR1..3.p2

Z-value: 2.179


Transcription factors associated with EGR1..3.p2:

Gene SymbolEntrez IDGene Name
EGR1 1958 early growth response 1
EGR2 1959 early growth response 2 (Krox-20 homolog, Drosophila)
EGR3 1960 early growth response 3



Activity profile for motif EGR1..3.p2.

activity profile for motif EGR1..3.p2


Sorted Z-values histogram for motif EGR1..3.p2

Sorted Z-values for motif EGR1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EGR1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_809879 4.849 NM_006651
CPLX1
complexin 1
chr2_+_104838177 3.741 NM_006236
POU3F3
POU class 3 homeobox 3
chr20_-_60074237 3.135 NM_003185
TAF4
TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
chr18_+_53253775 3.114 NM_004852
ONECUT2
one cut homeobox 2
chr1_+_41022066 2.910 NM_004700
NM_172163
KCNQ4

potassium voltage-gated channel, KQT-like subfamily, member 4

chr15_+_22644448 2.861


chr2_+_42128521 2.522 NM_138370
PKDCC
protein kinase domain containing, cytoplasmic homolog (mouse)
chr7_-_526005 2.427 NM_002607
NM_033023
PDGFA

platelet-derived growth factor alpha polypeptide

chr7_-_525556 2.389 PDGFA
platelet-derived growth factor alpha polypeptide
chr7_+_55922623 2.304 ZNF713
zinc finger protein 713
chr16_+_1143241 2.281 NM_001005407
NM_021098
CACNA1H

calcium channel, voltage-dependent, T type, alpha 1H subunit

chr2_+_10101081 2.045 NM_003597
NM_001177716
KLF11

Kruppel-like factor 11

chr3_-_185461768 2.018 NM_033259
CAMK2N2
calcium/calmodulin-dependent protein kinase II inhibitor 2
chr6_+_99389300 1.947 NM_005604
POU3F2
POU class 3 homeobox 2
chr1_+_38032045 1.909 NM_001031740
NM_001113482
MANEAL

mannosidase, endo-alpha-like

chr13_-_19633182 1.874 NM_021954
GJA3
gap junction protein, alpha 3, 46kDa
chr17_+_75366524 1.865 NM_005189
NM_032647
CBX2

chromobox homolog 2

chr17_+_77582774 1.835 NM_005052
RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr6_+_99389318 1.809 POU3F2
POU class 3 homeobox 2
chr20_-_61933012 1.787 ZBTB46
zinc finger and BTB domain containing 46

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 24 entries
Enrichment   P-value GO Accession GO Term
151.35 2.49e-02 GO:0021869 forebrain ventricular zone progenitor cell division
4.20 4.82e-02 GO:0009887 organ morphogenesis
3.75 1.33e-02 GO:0006351 transcription, DNA-dependent
3.62 9.26e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
3.53 4.94e-02 GO:0048699 generation of neurons
3.44 2.32e-04 GO:0007399 nervous system development
3.38 3.84e-02 GO:0032774 RNA biosynthetic process
3.23 3.75e-05 GO:0048513 organ development
2.77 7.30e-06 GO:0048731 system development
2.56 7.53e-03 GO:0006355 regulation of transcription, DNA-dependent
2.50 1.36e-05 GO:0007275 multicellular organismal development
2.49 9.42e-05 GO:0048856 anatomical structure development
2.49 3.05e-02 GO:0030154 cell differentiation
2.46 1.37e-02 GO:0051252 regulation of RNA metabolic process
2.42 4.52e-02 GO:0048869 cellular developmental process
2.41 1.18e-02 GO:2000112 regulation of cellular macromolecule biosynthetic process
2.35 1.81e-02 GO:0010556 regulation of macromolecule biosynthetic process
2.28 1.48e-04 GO:0032502 developmental process
2.28 1.89e-02 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.28 1.89e-02 GO:0031326 regulation of cellular biosynthetic process

Gene overrepresentation in compartment category:

Showing 1 to 5 of 5 entries
Enrichment   P-value GO Accession GO Term
23.50 2.39e-02 GO:0034704 calcium channel complex
11.78 1.71e-04 GO:0034703 cation channel complex
10.45 5.00e-02 GO:0008076 voltage-gated potassium channel complex
10.45 5.00e-02 GO:0034705 potassium channel complex
7.65 2.91e-03 GO:0034702 ion channel complex

Gene overrepresentation in function category:

Showing 1 to 16 of 16 entries
Enrichment   P-value GO Accession GO Term
34.06 8.69e-03 GO:0004683 calmodulin-dependent protein kinase activity
11.59 6.75e-03 GO:0005249 voltage-gated potassium channel activity
11.20 2.71e-04 GO:0022843 voltage-gated cation channel activity
9.02 2.21e-02 GO:0005267 potassium channel activity
8.51 1.66e-03 GO:0005244 voltage-gated ion channel activity
8.51 1.66e-03 GO:0022832 voltage-gated channel activity
6.89 1.85e-03 GO:0005261 cation channel activity
6.27 1.10e-04 GO:0015267 channel activity
6.26 1.12e-04 GO:0022803 passive transmembrane transporter activity
6.05 4.71e-03 GO:0022836 gated channel activity
5.88 6.29e-04 GO:0022838 substrate-specific channel activity
5.38 3.86e-03 GO:0005216 ion channel activity
4.06 4.68e-05 GO:0030528 transcription regulator activity
3.90 1.88e-04 GO:0001071 nucleic acid binding transcription factor activity
3.90 1.88e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
2.20 2.71e-02 GO:0003677 DNA binding